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Displaying results 71 - 80 of 259 in total
  1. Target

    Sodium channel protein type 9 subunit alpha

    go.drugbank.com/bio_entities/BE0001143
    TargetHumans

    Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes (PubMed:38381792, PubMed:40768348).

    Polypeptides: Sodium channel protein type 9 subunit alphaSynonyms: Peripheral sodium channel 1, Neuroendocrine sodium channel
  2. Target

    Sodium channel protein type 2 subunit alpha

    go.drugbank.com/bio_entities/BE0002081
    TargetHumans

    Mediates the voltage-dependent sodium ion permeability of excitable membranes. … Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their

    Polypeptides: Sodium channel protein type 2 subunit alphaSynonyms: Sodium channel protein brain II subunit alpha, Sodium channel protein type II subunit alpha
  3. Target

    Sodium channel protein type 3 subunit alpha

    go.drugbank.com/bio_entities/BE0002082
    TargetHumans

    Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … Pore-forming subunit of Nav1.3, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes.

    Polypeptides: Sodium channel protein type 3 subunit alphaSynonyms: Voltage-gated sodium channel subtype III, Sodium channel protein brain III subunit alpha
  4. Target

    Sodium/potassium-transporting ATPase subunit beta-1

    go.drugbank.com/bio_entities/BE0004994
    TransporterTargetHumans

    Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (PubMed:34011520) … Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs).

    Polypeptides: Sodium/potassium-transporting ATPase subunit beta-1Synonyms: Sodium/potassium-dependent ATPase subunit beta-1
  5. Target

    Sodium/potassium-transporting ATPase subunit beta-3

    go.drugbank.com/bio_entities/BE0005026
    TransporterTargetHumans

    This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

    Polypeptides: Sodium/potassium-transporting ATPase subunit beta-3Synonyms: Sodium/potassium-dependent ATPase subunit beta-3
  6. Target

    Sodium/potassium-transporting ATPase subunit alpha-2

    go.drugbank.com/bio_entities/BE0005034
    TargetTransporterHumans

    This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function (PubMed:33880529) … It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (By similarity).

    Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-2Synonyms: Sodium pump subunit alpha-2
  7. Target

    Sodium/potassium-transporting ATPase subunit alpha-3

    go.drugbank.com/bio_entities/BE0005047
    TargetTransporterHumans

    In the brain, ATP1A3 is critical for neuronal cell signaling and for maintenance of electrochemical stability, enabling cell excitation and action potential propagation (PubMed:33880529, PubMed:36075933 … Neuron-specific alpha catalytic component of the Na(+)/K(+)-transporting ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed

    Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-3Synonyms: Sodium pump subunit alpha-3
  8. Target

    Sodium-coupled neutral amino acid symporter 1

    go.drugbank.com/bio_entities/BE0009870
    TransporterHumans

    Symporter that cotransports short-chain neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10891391, PubMed:20599747). … The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391).

    Polypeptides: Sodium-coupled neutral amino acid symporter 1
  9. Target

    Sodium-coupled neutral amino acid symporter 2

    go.drugbank.com/bio_entities/BE0009871
    TransporterHumans

    The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. … Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10930503, PubMed:15774260, PubMed:15922329, PubMed:16621798

    Polypeptides: Sodium-coupled neutral amino acid symporter 2
  10. Target

    Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

    go.drugbank.com/bio_entities/BE0004631
    TargetHumans

    Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). … Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity).

    Polypeptides: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2