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Displaying results 71 - 80 of 225 in total
  1. Target

    TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

    go.drugbank.com/bio_entities/BE0005824
    TargetHumans

    Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530 … Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647).

    Polypeptides: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
  2. Target

    O-phosphoseryl-tRNA(Sec) selenium transferase

    go.drugbank.com/bio_entities/BE0002171
    TargetHumans

    Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis

    Polypeptides: O-phosphoseryl-tRNA(Sec) selenium transferaseFunction: O-phosphoseryl-tRNA(Sec) selenium transferase activity
  3. Target

    Membrane-bound glycerophospholipid O-acyltransferase 2

    go.drugbank.com/bio_entities/BE0015719
    EnzymeHumans

    ) and lysophosphatidylserine (LPS) (PubMed:18772128). … Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid

    Polypeptides: Membrane-bound glycerophospholipid O-acyltransferase 2Synonyms: 1-acylglycerophosphate O-acyltransferase MBOAT2, 1-acylglycerophosphocholine O-acyltransferase MBOAT2
  4. Target

    Carnitine O-palmitoyltransferase 1, muscle isoform

    go.drugbank.com/bio_entities/BE0017721
    TargetHumans

    Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation

    Polypeptides: Carnitine O-palmitoyltransferase 1, muscle isoformSynonyms: Carnitine O-palmitoyltransferase I, muscle isoform
  5. Target

    Carnitine O-palmitoyltransferase 1, liver isoform

    go.drugbank.com/bio_entities/BE0000406
    TargetHumans

    Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase … Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation

    Polypeptides: Carnitine O-palmitoyltransferase 1, liver isoformSynonyms: Carnitine O-palmitoyltransferase I, liver isoform
  6. Target

    General transcription and DNA repair factor IIH helicase/translocase subunit XPB

    go.drugbank.com/bio_entities/BE0012820
    TargetHumans

    The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape (PubMed:10024882). … In transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107).

    Polypeptides: General transcription and DNA repair factor IIH helicase/translocase subunit XPB
  7. Target

    UDP-3-O-acyl-N-acetylglucosamine deacetylase

    go.drugbank.com/bio_entities/BE0001333
    TargetAquifex aeolicus (strain VF5)

    Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

    Polypeptides: UDP-3-O-acyl-N-acetylglucosamine deacetylaseSynonyms: UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
  8. Target

    Heparan sulfate glucosamine 3-O-sulfotransferase 3A1

    go.drugbank.com/bio_entities/BE0001541
    TargetHumans

    Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2 (PubMed:10520990, PubMed:15304505, PubMed:9988768). … The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry (PubMed:10520990).

    Polypeptides: Heparan sulfate glucosamine 3-O-sulfotransferase 3A1Synonyms: Heparan sulfate 3-O-sulfotransferase 3A1, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1
  9. Target

    Heparan sulfate glucosamine 3-O-sulfotransferase 1

    go.drugbank.com/bio_entities/BE0004436
    TargetHumans

    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan (PubMed:8900198, PubMed:9346953, PubMed:9988768). Catalyzes the rate limiting...

    Polypeptides: Heparan sulfate glucosamine 3-O-sulfotransferase 1Synonyms: Heparan sulfate 3-O-sulfotransferase 1, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1
  10. Target

    Catechol O-methyltransferase domain-containing protein 1

    go.drugbank.com/bio_entities/BE0004586
    TargetHumans

    Putative O-methyltransferase

    Polypeptides: Catechol O-methyltransferase domain-containing protein 1Function: O-methyltransferase activity