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Sodium channel protein type 7 subunit alpha
go.drugbank.com/bio_entities/BE0009590TargetHumansSodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. … While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient (PubMed:26537257, PubMed:35301303).
Polypeptides: Sodium channel protein type 7 subunit alphaSynonyms: Atypical sodium channel Nav2.1, Sodium channel protein type VII subunit alphaSodium channel protein type 1 subunit alpha
go.drugbank.com/bio_entities/BE0000141TargetHumansNavs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … Pore-forming subunit of Nav1.1, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes.
Polypeptides: Sodium channel protein type 1 subunit alphaSynonyms: Sodium channel protein brain I subunit alpha, Sodium channel protein type I subunit alphaSodium channel protein type 10 subunit alpha
go.drugbank.com/bio_entities/BE0000177TargetHumansAssuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their … Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes.
Polypeptides: Sodium channel protein type 10 subunit alphaSynonyms: Peripheral nerve sodium channel 3, Sodium channel protein type X subunit alphaSodium channel protein type 5 subunit alpha
go.drugbank.com/bio_entities/BE0000197TargetHumansNavs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat (PubMed
Polypeptides: Sodium channel protein type 5 subunit alphaSynonyms: Sodium channel protein type V subunit alpha, Sodium channel protein cardiac muscle subunit alphaSodium channel protein type 9 subunit alpha
go.drugbank.com/bio_entities/BE0001143TargetHumansNavs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes (PubMed:38381792, PubMed:40768348).
Polypeptides: Sodium channel protein type 9 subunit alphaSynonyms: Neuroendocrine sodium channel, Peripheral sodium channel 1Sodium channel protein type 2 subunit alpha
go.drugbank.com/bio_entities/BE0002081TargetHumansMediates the voltage-dependent sodium ion permeability of excitable membranes. … Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their
Polypeptides: Sodium channel protein type 2 subunit alphaSynonyms: Sodium channel protein brain II subunit alpha, Sodium channel protein type II subunit alphaSodium channel protein type 3 subunit alpha
go.drugbank.com/bio_entities/BE0002082TargetHumansNavs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … Pore-forming subunit of Nav1.3, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes.
Polypeptides: Sodium channel protein type 3 subunit alphaSynonyms: Voltage-gated sodium channel subtype III, Sodium channel protein brain III subunit alphaSodium/potassium-transporting ATPase subunit beta-1
go.drugbank.com/bio_entities/BE0004994TransporterTargetHumansMechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (PubMed:34011520) … Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs).
Polypeptides: Sodium/potassium-transporting ATPase subunit beta-1Synonyms: Sodium/potassium-dependent ATPase subunit beta-1Sodium/potassium-transporting ATPase subunit beta-3
go.drugbank.com/bio_entities/BE0005026TransporterTargetHumansThis is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.
Polypeptides: Sodium/potassium-transporting ATPase subunit beta-3Synonyms: Sodium/potassium-dependent ATPase subunit beta-3Sodium/potassium-transporting ATPase subunit alpha-2
go.drugbank.com/bio_entities/BE0005034TargetTransporterHumansThis process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function (PubMed:33880529) … It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (By similarity).
Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-2Synonyms: Sodium pump subunit alpha-2