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Displaying results 791 - 800 of 10000 in total

Target
Cytochrome P450 2C8
go.drugbank.com/bio_entities/BE0002887
TargetEnzymeHumans
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576, PubMed:7574697). Mecha...
Synonyms: S-mephenytoin 4-hydroxylase
Drug
Travoprost
go.drugbank.com/drugs/DB00287
ApprovedInvestigational
It is used to decrease intraocular pressure in open-angle glaucoma and ocular hypertension. … Travoprost is a synthetic isopropyl ester prodrug of a prostaglandin F2alpha (F2α) analogue and selective FP prostanoid receptor agonist.
Synonyms: (1R-(1.ALPHA.(Z),2.BETA.(1E,3R*),3.ALPHA.,5.ALPHA.))-7-(3,5-DIHYDROXY-2-(3-HYDROXY-4-(3-(TRIFLUOROMETHYL)PHENOXY)-1-BUTENYL)CYCLOPENTYL)-5-HEPTENOIC ACID, 1-METHYLETHYL ESTER, isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(α,α,α-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoateInternational brands: Travo-Z
Drug
Galantamine
go.drugbank.com/drugs/DB00674
ApprovedInvestigational
As Alzheimer's disease is a progressive neurodegenerative disorder, galantamine is not known to alter the course of the underlying dementing process. … Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: ANTAMIN ® 8 MG, REMINYL ®ER CAPSULAS DE 8 MG
Drug
Ethanol
go.drugbank.com/drugs/DB00898
ApprovedInvestigational
It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages. … A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant.
Mixtures: Adventure Medical Kits 1-4 Person First Aid, Polylab Surgical Spirit 98.8% v/vCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inducers
Indication
Von Willebrand's Disease
go.drugbank.com/conditions/DBCOND0028947
Drugs: Antihemophilic factor human · Beroctocog alfa · Desmopressin · Von Willebrand factor human · Vonicog alfa
Synonyms: Von Willebrand 's disease Type 1
Target
Excretory Secretory (ES) proteins
go.drugbank.com/bio_entities/BE0009630
TargetFasciola hepatica
Synonyms: Glutathione S-transferase omega classPolypeptides: Glutathione S-transferase omega class
Target
Laminin subunit gamma-1
go.drugbank.com/bio_entities/BE0002107
TargetHumans
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a su...
Synonyms: S-LAM gamma, S-laminin subunit gamma
Drug
Omeprazole
go.drugbank.com/drugs/DB00338
ApprovedInvestigationalVet approved
Originally approved by the FDA in 1989, omeprazole is a _proton-pump inhibitor_, used to treat gastric acid-related disorders. … Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults [FDA label].
Mixtures: ORAZOLE ® 10 MG CAPSULACategories: P-glycoprotein inhibitors, P-glycoprotein substrates
Target
Kynurenine--oxoglutarate transaminase 3
go.drugbank.com/bio_entities/BE0002162
TargetHumans
May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.
Synonyms: Cysteine-S-conjugate beta-lyase 2Function: cysteine-S-conjugate beta-lyase activity
Target
Nitric oxide synthase 1
go.drugbank.com/bio_entities/BE0000067
TargetEnzymeHumans
Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR
Synonyms: Peptidyl-cysteine S-nitrosylase NOS1