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Displaying results 801 - 810 of 3735 in total
  1. Target

    Fibroblast growth factor receptor 1

    go.drugbank.com/bio_entities/BE0002131
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and

    Polypeptides: Fibroblast growth factor receptor 1Synonyms: Basic fibroblast growth factor receptor 1
  2. Target

    Fibroblast growth factor receptor 3

    go.drugbank.com/bio_entities/BE0002133
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis.

    Polypeptides: Fibroblast growth factor receptor 3
  3. Target

    Prostaglandin E2 receptor EP3 subtype

    go.drugbank.com/bio_entities/BE0002375
    TargetHumans

    Receptor for prostaglandin E2 (PGE2) (PubMed:7883006, PubMed:7981210, PubMed:8117308, PubMed:8135729, PubMed:8307176). … The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium (PubMed:7883006, PubMed:7981210, PubMed:8117308

    Polypeptides: Prostaglandin E2 receptor EP3 subtypeSynonyms: PGE receptor EP3 subtype, Prostanoid EP3 receptor
  4. Target

    Interleukin-4 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0002420
    TargetHumans

    In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 … Receptor for both interleukin 4 and interleukin 13 (PubMed:17030238). Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation.

    Polypeptides: Interleukin-4 receptor subunit alphaSynonyms: IL-4 receptor subunit alpha
  5. Target

    Sphingosine 1-phosphate receptor 5

    go.drugbank.com/bio_entities/BE0002432
    TargetHumans

    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

    Polypeptides: Sphingosine 1-phosphate receptor 5Synonyms: S1P receptor 5, S1P receptor Edg-8
  6. Target

    Neuropeptide Y receptor type 5

    go.drugbank.com/bio_entities/BE0002452
    TargetHumans

    Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake.

    Polypeptides: Neuropeptide Y receptor type 5Synonyms: Y5 receptor, NPY-Y5 receptor
  7. Target

    Ephrin type-B receptor 4

    go.drugbank.com/bio_entities/BE0002453
    TargetHumans

    The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. … Receptor tyrosine kinase which binds promiscuously to transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.

    Polypeptides: Ephrin type-B receptor 4
  8. Target

    Free fatty acid receptor 4

    go.drugbank.com/bio_entities/BE0003399
    TargetHumans

    Acts as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that … After LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (PubMed

    Polypeptides: Free fatty acid receptor 4Synonyms: G protein-coupled receptor 120, G protein-coupled receptor 129
  9. Target

    Melanin-concentrating hormone receptor 1

    go.drugbank.com/bio_entities/BE0003478
    TargetHumans

    G protein-coupled receptor for melanin-concentrating hormone (MCH) that signals primarily through G(i/o) to inhibit adenylyl cyclase, and can additionally couple to G(q/11) to stimulate phospholipase C

    Polypeptides: Melanin-concentrating hormone receptor 1Synonyms: MCH receptor 1, G protein-coupled receptor 24
  10. Target

    Nuclear receptor-interacting protein 1

    go.drugbank.com/bio_entities/BE0003742
    TargetHumans

    Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transc...

    Polypeptides: Nuclear receptor-interacting protein 1Synonyms: Receptor-interacting protein 140