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Interleukin-4 receptor subunit alpha
go.drugbank.com/bio_entities/BE0002420TargetHumansIn certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 … Receptor for both interleukin 4 and interleukin 13 (PubMed:17030238). Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation.
Polypeptides: Interleukin-4 receptor subunit alphaSynonyms: IL-4 receptor subunit alphaSphingosine 1-phosphate receptor 5
go.drugbank.com/bio_entities/BE0002432TargetHumansReceptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.
Polypeptides: Sphingosine 1-phosphate receptor 5Synonyms: S1P receptor 5, S1P receptor Edg-8Neuropeptide Y receptor type 5
go.drugbank.com/bio_entities/BE0002452TargetHumansReceptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake.
Polypeptides: Neuropeptide Y receptor type 5Synonyms: Y5 receptor, NPY-Y5 receptorEphrin type-B receptor 4
go.drugbank.com/bio_entities/BE0002453TargetHumansThe signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. … Receptor tyrosine kinase which binds promiscuously to transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
Polypeptides: Ephrin type-B receptor 4Free fatty acid receptor 4
go.drugbank.com/bio_entities/BE0003399TargetHumansAfter LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (PubMed … G protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation.
Polypeptides: Free fatty acid receptor 4Synonyms: G protein-coupled receptor 120, G protein-coupled receptor 129Melanin-concentrating hormone receptor 1
go.drugbank.com/bio_entities/BE0003478TargetHumansG protein-coupled receptor for melanin-concentrating hormone (MCH) that signals primarily through G(i/o) to inhibit adenylyl cyclase, and can additionally couple to G(q/11) to stimulate phospholipase C
Polypeptides: Melanin-concentrating hormone receptor 1Synonyms: MCH receptor 1, G protein-coupled receptor 24Nuclear receptor-interacting protein 1
go.drugbank.com/bio_entities/BE0003742TargetHumansPositive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC.
Polypeptides: Nuclear receptor-interacting protein 1Synonyms: Receptor-interacting protein 140Very low-density lipoprotein receptor
go.drugbank.com/bio_entities/BE0004020TargetCarrierHumansMultifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. … Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (PubMed:30873003
Polypeptides: Very low-density lipoprotein receptorSynonyms: VLDL receptorEphrin type-A receptor 7
go.drugbank.com/bio_entities/BE0004140TargetHumansReceptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
Polypeptides: Ephrin type-A receptor 7Interleukin-1 receptor antagonist protein
go.drugbank.com/bio_entities/BE0004735TargetHumansAnti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for ...
Polypeptides: Interleukin-1 receptor antagonist protein