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Displaying results 841 - 850 of 10000 in total
  1. Drug

    Ondansetron

    go.drugbank.com/drugs/DB00904
    ApprovedInvestigationalWithdrawn

    Having been developed in the 1980s by GlaxoSmithKline and approved by the US FDA since January 1991, ondansetron has demonstrated a long history of use and efficacy. … It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, P-glycoprotein substratesProducts: Nu-ondansetron, NODANTON-I
  2. Drug

    Lisinopril

    go.drugbank.com/drugs/DB00722
    ApprovedInvestigational

    [A184853] It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system. … Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.

    Synonyms: (S)-1-(N(2)-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline, [N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-prolineMixtures: Nu-lisinopril/hctz, Nu-lisinopril/hctz
  3. Target

    GTP cyclohydrolase 1

    go.drugbank.com/bio_entities/BE0001814
    TargetShigella flexneri

    Synonyms: GTP-CH-I, GTP cyclohydrolase I
  4. Target

    Carbamoyl-phosphate synthase [ammonia], mitochondrial

    go.drugbank.com/bio_entities/BE0004671
    TargetEnzymeHumans

    Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell

    Synonyms: CPSase I, Carbamoyl-phosphate synthetase I
  5. Target

    Deoxyribonuclease-1

    go.drugbank.com/bio_entities/BE0012829
    TargetHumans

    Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:11241278, PubMed:2251263, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By sim...

    Synonyms: DNase I, Deoxyribonuclease IFunction: deoxyribonuclease I activity
  6. Indication

    Accelerated Phase Chronic Myelogenous Leukemia (CML)

    go.drugbank.com/conditions/DBCOND0121922
    Drugs: Bosutinib · Dasatinib · Imatinib · Nilotinib · Ponatinib
    Synonyms: Chronic myelogenous leukemia, no ICD-O subtype, Chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality)
  7. Indication

    Classical Hodgkin's Lymphoma

    go.drugbank.com/conditions/DBCOND0113588
    Drugs: Brentuximab vedotin · Nivolumab
    Synonyms: Hodgkin lymphoma, no ICD-O subtype, Hodgkin lymphoma, no ICD-O subtype (morphologic abnormality)
  8. Drug

    Perindopril

    go.drugbank.com/drugs/DB00790
    ApprovedInvestigational

    Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). … It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration.

    Synonyms: (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acidMixtures: COVERATRIX 5 MG/1.25 MG/10 MG COMPRIMIDOS RECUBIERTOS CON PELÍCULA, COVERATRIX 10 MG / 2.5 MG / 5 MG COMPRIMIDOS RECUBIERTOS CON PELÍCULA
  9. Drug

    Simvastatin

    go.drugbank.com/drugs/DB00641
    ApprovedInvestigational

    It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the … [A181409,A181535,A181538,A1793] Potency is thought to correlate to tissue permeability as the more lipophilic statins such as simvastatin are thought to enter endothelial cells by passive diffusion, as

    Synonyms: 2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-oneMixtures: TIAZOMET S®, TIAZOMET S®
  10. Target

    Serine protease 1

    go.drugbank.com/bio_entities/BE0001739
    TargetEnzymeHumans

    Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates

    Synonyms: Trypsin I, Anionic trypsin I