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Nateglinide
go.drugbank.com/drugs/DB00731ApprovedThe average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas and insulin and appears to occur only in those naïve to oral antidiabetic agents. … Nateglinide is an amino acid derivative that induces an early insulin response to meals decreasing postprandial blood glucose levels.
Categories: Drugs Used in Diabetes, Alimentary Tract and MetabolismProducts: Starlix 60mg, Starlix 120mgMirabegron
go.drugbank.com/drugs/DB08893ApprovedInvestigational[L32853] An extended-release granule formulation was subsequently granted approval in March 2021 for the treatment of pediatric patients with neurogenic detrusor overactivity. … [L32853] Mirabegron is also used in other jurisdictions across the globe, including Canada,[L32925] the EU,[L32945] and Japan.[A7469]
Categories: Genito Urinary System and Sex Hormones, Drugs for Urinary Frequency and IncontinenceProducts: Betmiga prolonged-release tablets 25mg, PROLONGED-RELEASE TABLETS 25MGNeostigmine
go.drugbank.com/drugs/DB01400ApprovedInvestigationalVet approvedA cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine.
Synonyms: 3-Trimethylammoniumphenyl N,N-dimethylcarbamateCategories: Antiglaucoma Preparations and MioticsApoptotic DNA Fragmentation and Tissue Homeostasis
smpdb.ca/view/SMP0063772SignalingICAD and CAD exist in the nucleus in normal cells and is a major endonuclease in apoptosis. Its activation is normally caspase dependent. … EndoG resides in mitochondria in normal cells and travels to the nucleus, where it fragments chromosomal DNA upon activation of apoptosis.
Drugs: ZincEnzymes: CAD proteinMetabolism and Physiological Effects of Creatinine
smpdb.ca/view/SMP0123283MetabolicCreatinine is a low-molecular-weight uremic solute and breakdown product of creatine phosphate in muscle, often used as a clinical marker of renal function (altered serum creatinine clearance levels can … If not cleared, it can reduce cardiomyocyte contractility and weaken cardiac efficiency, leading to systolic dysfunction and heart failure.
Metabolism and Physiological Effects of Xanthine
smpdb.ca/view/SMP0124865MetabolicPurines can be made endogenously in the body or can be obtained exogenously from foods such as red meat. The purines are guanine and adenine. These undergo metabolism in the liver to form xanthine. … Xanthine then enters the blood where it can have detrimental effects on other organs such as the kidney (causing renal failure) and the blood vessel (causing endothelial dysfunction).
Metabolism and Physiological Effects of Kynurenine
smpdb.ca/view/SMP0125524DiseaseIn addition to increased kynurenine production via IDO mediated synthesis, hyopalbuminemia can also lead to the release of bound kynurenine (and other immunosuppressive LysoPCs) into the bloodstream to … In the blood it travels to the liver and is transported into a hepatocyte by an amino acid transporter.
Enzymes: Neutral and basic amino acid transport protein rBATMetabolism and Physiological Effects of Isovalerylglycine
smpdb.ca/view/SMP0126748MetabolicIn certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. … IVA (OMIM/ McKusick 243500) is an autosomal recessive disorder caused by mutations in the isovaleryl-CoA dehydrogenase (EC 1.3.99.10) gene.
Metabolism and Physiological Effects of Tiglylglycine
smpdb.ca/view/SMP0126840MetabolicIn certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. … This is then converted to tiglyl-CoA by SBCAD which can then be made into tiglylglycine via glycine N-acyltransferase.
Metabolism and Physiological Effects of Citrulline
smpdb.ca/view/SMP0126861MetabolicIn addition, citrulline and L-aspartic acid can be converted into argininosuccinic acid through the action of the enzyme argininosuccinate synthase. … In particular, citrulline can be biosynthesized from carbamoyl phosphate and ornithine which is catalyzed by the enzyme ornithine carbamoyltransferase.