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gamma-Glutamyltranspeptidase Deficiency
smpdb.ca/view/SMP0125618DiseaseGamma-glutamyltranspeptidase deficiency, characterized by glutathionemia and glutathionuria, is an autosomal recessive disorder of glutathione metabolism caused by a defective gamma-glutamyl transpeptidase (GGT). GGT transfers glutamyl m...
Enzymes: Glutathione S-transferase omega-2Metformin
go.drugbank.com/drugs/DB00331ApprovedInvestigationalIt is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and a clinically significant reduction of plasma fasting insulin levels. … Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.
Mixtures: AMARYL® M SR, AMARYL® M SRCategories: MATE 1 Substrates, MATE 2 SubstratesIsopropyl alcohol
go.drugbank.com/drugs/DB02325ApprovedInvestigationalAn isomer of 1-propanol. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.
Mixtures: Anesthesia S/I-60, Anesthesia S/I-40Categories: Compounds used in a research, industrial, or household settingCarboprost tromethamine Action Pathway
smpdb.ca/view/SMP0127007Drug actionCarboprost tromethamine is a medication primarily used in obstetrics and gynecology for two distinct purposes. First, it is employed as an abortifacient agent in the second trimester of pregnancy, typically between the 13th and 20th week...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Alprostadil Action Pathway
smpdb.ca/view/SMP0127008Drug actionAlprostadil is a medication used for two distinct purposes. First, it is employed in the treatment of erectile dysfunction in men for whom oral treatment is either contraindicated or ineffective. It can be administered either through an ...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Iloprost Action Pathway
smpdb.ca/view/SMP0126507Drug actionIloprost is a prostacyclin analog also known as Ventavis, that acts to prevent platelet aggregation. It is a second-generation analog that is structurally similar to prostacyclin. It binds to prostacyclin receptors that activate adenylyl...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Bimatoprost Action Pathway
smpdb.ca/view/SMP0127009Drug actionBimatoprost is a prostaglandin analog with multiple medical applications. It belongs to the prostamide group of drugs and is available in both ophthalmic solution and implant forms. Primarily, bimatoprost is used to manage elevated intra...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Dinoprostone Action Pathway
smpdb.ca/view/SMP0127013Drug actionDinoprostone is a naturally occurring prostaglandin E2 (PGE2) with significant roles in various physiological processes, most notably in labor. This medication, available as a vaginal suppository, is used for several medical purposes. Fi...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Glutathione Metabolism
smpdb.ca/view/SMP0000015MetabolicGlutathione (GSH) is an low-molecular-weight thiol and antioxidant in various species such as plants, mammals and microbes. Glutathione plays important roles in nutrient metabolism, gene expression, etc. and sufficient protein nutrition ...
Enzymes: Glutathione S-transferase omega-25-Oxoprolinase Deficiency
smpdb.ca/view/SMP0000500Disease5-Oxoprolinase deficiency, also called OPLAHD, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of glutathione metabolism caused by a defective 5-oxoprolinase. 5-Oxoprolinase catalyzes the conversion of 5-oxopr...
Enzymes: Glutathione S-transferase omega-2