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Transferrin receptor protein 1
go.drugbank.com/bio_entities/BE0008725TargetHumansCellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738, PubMed:41772062). … The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.
Polypeptides: Transferrin receptor protein 1Synonyms: Transferrin receptor 1Proteinase-activated receptor 4
go.drugbank.com/bio_entities/BE0008986TargetHumansReceptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis (PubMed:10079109). May play a role in platelets activation (PubMed:10079109)
Polypeptides: Proteinase-activated receptor 4Synonyms: Thrombin receptor-like 3, Coagulation factor II receptor-like 3Macrophage mannose receptor 1
go.drugbank.com/bio_entities/BE0009334TargetHumansMediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains
Polypeptides: Macrophage mannose receptor 1Synonyms: Human mannose receptor, Macrophage mannose receptor 1-like protein 1Insulin receptor-related protein
go.drugbank.com/bio_entities/BE0009451TargetHumansReceptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH.
Polypeptides: Insulin receptor-related proteinSynonyms: IR-related receptor5-hydroxytryptamine receptor 3B
go.drugbank.com/bio_entities/BE0009583TargetHumansForms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons
Polypeptides: 5-hydroxytryptamine receptor 3BSynonyms: Serotonin receptor 3B5-hydroxytryptamine receptor 3E
go.drugbank.com/bio_entities/BE0009586TargetHumansForms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons
Polypeptides: 5-hydroxytryptamine receptor 3ESynonyms: Serotonin receptor 3ECX3C chemokine receptor 1
go.drugbank.com/bio_entities/BE0010049TargetHumansAlso acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (PubMed:20974991) … Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response
Polypeptides: CX3C chemokine receptor 1Synonyms: Fractalkine receptor, Beta chemokine receptor-like 1Proteinase-activated receptor 2
go.drugbank.com/bio_entities/BE0010726TargetHumansReceptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). … Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time.
Polypeptides: Proteinase-activated receptor 2Synonyms: Thrombin receptor-like 1, G protein-coupled receptor 11Gastric inhibitory polypeptide receptor
go.drugbank.com/bio_entities/BE0011012TargetHumansThis is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Polypeptides: Gastric inhibitory polypeptide receptorSynonyms: Glucose-dependent insulinotropic polypeptide receptorToll-like receptor 5
go.drugbank.com/bio_entities/BE0011820TargetHumansPattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781).
Polypeptides: Toll-like receptor 5Synonyms: Toll/interleukin-1 receptor-like protein 3