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Displaying results 81 - 90 of 509 in total
  1. Target

    Sodium-dependent serotonin transporter

    go.drugbank.com/bio_entities/BE0000749
    TargetTransporterHumans

    Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. … Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied.

    Polypeptides: Sodium-dependent serotonin transporter
  2. Target

    Sodium/hydrogen exchanger 1

    go.drugbank.com/bio_entities/BE0000752
    TargetTransporterHumans

    Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933, … In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter (PubMed:7603840).

    Polypeptides: Sodium/hydrogen exchanger 1
  3. Target

    Sodium bicarbonate cotransporter 3

    go.drugbank.com/bio_entities/BE0004676
    TransporterHumans

    Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry (PubMed:10347222, PubMed:12403779, PubMed:14578046, PubMed:14736710). … Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (By similarity

    Polypeptides: Sodium bicarbonate cotransporter 3Synonyms: Sodium bicarbonate cotransporter 2, Sodium bicarbonate cotransporter 2b
  4. Target

    Sodium/nucleoside cotransporter 1

    go.drugbank.com/bio_entities/BE0004705
    TransporterHumans

    Sodium and pyrimidine nucleoside symporter of the plasma membrane that imports uridine, thymidine and cytidine into cells by coupling their transport to the transmembrane sodium electrochemical gradient … Also transports adenosine, an atypical substrate transported with high apparent affinity, but low maximum velocity.

    Polypeptides: Sodium/nucleoside cotransporter 1Synonyms: Sodium-coupled nucleoside transporter 1
  5. Target

    Sodium/glucose cotransporter 2

    go.drugbank.com/bio_entities/BE0004753
    TargetTransporterHumans

    Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1 (PubMed:20980548, PubMed:28592437, PubMed:34880493, PubMed:37217492, PubMed:38057552). Tran...

    Polypeptides: Sodium/glucose cotransporter 2Synonyms: Low affinity sodium-glucose cotransporter
  6. Target

    Sodium/glucose cotransporter 1

    go.drugbank.com/bio_entities/BE0004754
    TransporterTargetHumans

    Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (By similarity) (PubMed:8563765 … Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine

    Polypeptides: Sodium/glucose cotransporter 1Synonyms: High affinity sodium-glucose cotransporter
  7. Target

    Sodium/nucleoside cotransporter 2

    go.drugbank.com/bio_entities/BE0004781
    TransporterHumans

    Sodium-dependent and purine-selective transporter (PubMed:10087507, PubMed:9435697). … Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues (PubMed:9435697).

    Polypeptides: Sodium/nucleoside cotransporter 2Synonyms: Sodium-coupled nucleoside transporter 2, Sodium/purine nucleoside co-transporter
  8. Target

    Sodium/hydrogen exchanger 3

    go.drugbank.com/bio_entities/BE0009757
    TargetTransporterHumans

    Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:24622516, PubMed:26358773) … Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity).

    Polypeptides: Sodium/hydrogen exchanger 3
  9. Target

    Sodium/Potassium Transporting ATPase

    go.drugbank.com/bio_entities/BE0010055
    TargetTransporterHumans

    Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity … May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase

    Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-2Synonyms: Sodium pump subunit alpha-1, Sodium pump subunit alpha-2
  10. Target

    Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

    go.drugbank.com/bio_entities/BE0002559
    TargetHumans

    Plays a role in determining the extent and pattern of sulfation of heparan sulfate. … Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (PubMed:35137078, PubMed:9230113, PubMed:9744796

    Polypeptides: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1Synonyms: N-heparan sulfate sulfotransferase 1, [Heparan sulfate]-glucosamine N-sulfotransferase 1