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Tranexamic Acid Action Pathway (New)
smpdb.ca/view/SMP0124487Drug actionTranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It targets plasminogen in blood vessels where these clots occur. … Tranexamic acid competitively and reversibly inhibits the activation of plasminogen via binding at several distinct sites, including four or five low-affinity sites and one high-affinity site.
Mefenamic Acid NSAID Action Pathway
smpdb.ca/view/SMP0124586Drug actionMefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. It has analgesic, anti-inflammatory, and antipyretic properties. … Mefenamic acid inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2).
Salicylic Acid COX Action Pathway
smpdb.ca/view/SMP0124590Drug actionSalicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. … Salicylic acid inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2).
Tiaprofenic Acid Action Pathway (New)
smpdb.ca/view/SMP0124607Drug actionTiaprofenic acid possess anti-inflammatory, analgesic and antipyretic activity. … Tiaprofenic acid is a nonsteroidal anti-inflammatory (NSAID) used to manage inflammation and analgesia associated with rheumatoid arthritis and osteoarthritis.
Drugs: Glutathione · Dinoprostone · Calcium · Tiaprofenic acid · Mesoheme · Prostaglandin G2 +1 moreMycophenolic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174716MetabolicMetabolites of Mycophenolic acid are predicted with biotransformer.
Fatty Acid Elongation in Mitochondria
smpdb.ca/view/SMP0000054MetabolicThere are 3 major processes that modify palmitic acid: elongation, desaturation and hydroxylation. … To create longer, shorter, oxidized, reduced fatty acids, palmitic acid is subjected to enzymatic reactions by reductases, hydroxylases, elongases and mixed function oxidases.
3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
smpdb.ca/view/SMP0000521Diseaseacid. … 3-Hydroxyisobutyric acid dehydrogenase deficiency (3-hydroxyisobutyric aciduria) is an extremely rare inborn error of metabolism (IEM), potentially caused by numerous mechanisms.
Enzymes: Branched-chain-amino-acid aminotransferase, cytosolic, Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrialAcetylsalicylic Acid Action Pathway (New)
smpdb.ca/view/SMP0124628Drug actionAspirin (acetylsalicylic acid) is an NSAID used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. … The cyclooxygenase pathway begins in the cytosol with phospholipids being converted into arachidonic acid by the action of phospholipase A2.
Drugs: Glutathione · Dinoprostone · Acetylsalicylic acid · Calcium · Mesoheme · Prostaglandin G2 +1 moreNalidixic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174549MetabolicMetabolites of Nalidixic acid are predicted with biotransformer.
Iocetamic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174586MetabolicMetabolites of Iocetamic acid are predicted with biotransformer.