Search
Complement C4-B
go.drugbank.com/bio_entities/BE0004686TargetHumansPrecursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
go.drugbank.com/bio_entities/BE0000525TargetHumansMay play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091) … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371).
Synonyms: Gene associated with retinoic and IFN-induced mortality 19 protein, Gene associated with retinoic and interferon-induced mortality 19 proteinZinc transporter ZIP10
go.drugbank.com/bio_entities/BE0009884TransporterHumansWhen associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). … Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity).
Synonyms: Zrt- and Irt-like protein 10RNA-splicing ligase RTCB
go.drugbank.com/bio_entities/BE0004442TargetHumansThe covalently bound GMP is then transferred to this 3' phosphate to form an RNA(3')-P-P-(5')G intermediate. … These exon ends are then recognized and ligated by RTCB.
Synonyms: RNA 2',3'-cyclic phosphate and 5'-OH ligaseThioredoxin reductase 1, cytoplasmic
go.drugbank.com/bio_entities/BE0001979TargetEnzymeHumansHomodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. … Reduces disulfide protein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704).
Synonyms: Gene associated with retinoic and IFN-induced mortality 12 protein, Gene associated with retinoic and interferon-induced mortality 12 proteinNuclear receptor subfamily 1 group I member 2
go.drugbank.com/bio_entities/BE0000956TargetHumansUpon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation. … Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds.
Synonyms: Steroid and xenobiotic receptorRetinol dehydrogenase 12
go.drugbank.com/bio_entities/BE0000726TargetHumansMay play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838). … Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol (PubMed:12226107, PubMed:15865448).
Synonyms: All-trans and 9-cis retinol dehydrogenaseCytoplasmic tyrosine-protein kinase BMX
go.drugbank.com/bio_entities/BE0009416TargetHumansActivation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. … Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation.
Synonyms: Epithelial and endothelial tyrosine kinaseMyeloid zinc finger 1
go.drugbank.com/bio_entities/BE0013131TargetHumansBinds to target promoter DNA and functions as a transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter.
Synonyms: Zinc finger and SCAN domain-containing protein 6NADPH oxidase organizer 1
go.drugbank.com/bio_entities/BE0002423TargetHumansTogether with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity … Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the
Synonyms: SH3 and PX domain-containing protein 5