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Displaying results 81 - 90 of 225 in total
  1. Target

    Protein-L-isoaspartate(D-aspartate) O-methyltransferase

    go.drugbank.com/bio_entities/BE0001144
    TargetEnzymeHumans

    Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl … and alpha-synuclein (By similarity)

    Polypeptides: Protein-L-isoaspartate(D-aspartate) O-methyltransferase
  2. Target

    Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase

    go.drugbank.com/bio_entities/BE0001402
    TargetVACV

    Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. … At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap.

    Polypeptides: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferaseFunction: mRNA (nucleoside-2'-O-)-methyltransferase activity
  3. Target

    UDP-3-O-acyl-N-acetylglucosamine deacetylase

    go.drugbank.com/bio_entities/BE0004110
    TargetPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

    Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

    Polypeptides: UDP-3-O-acyl-N-acetylglucosamine deacetylaseSynonyms: UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
  4. Target

    Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

    go.drugbank.com/bio_entities/BE0005530
    TargetHumans

    Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). … In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049).

    Polypeptides: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENSynonyms: Phosphatase and tensin homolog
  5. Target

    High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

    go.drugbank.com/bio_entities/BE0003717
    TargetHumans

    Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299) … May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167).

    Polypeptides: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
  6. Target

    Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

    go.drugbank.com/bio_entities/BE0008997
    TargetHumans

    Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. … S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs.

    Polypeptides: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1Synonyms: Cap1 2'O-ribose methyltransferase 1
  7. Target

    16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA

    go.drugbank.com/bio_entities/BE0009727
    TargetMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

    Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA (PubMed:16857584, PubMed:20854656). Is likely involved in ribosomal biogenesis (PubMed:21443791). … Also exhibits hemolytic activity in vitro, by binding with and oligomerizing into host cell membranes (PubMed:20854656, PubMed:9611795).

    Polypeptides: 16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyASynonyms: 16S rRNA (cytidine1409-2'-O)-methyltransferase, 23S rRNA (cytidine1920-2'-O)-methyltransferase
  8. Target

    tRNA (cytidine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase

    go.drugbank.com/bio_entities/BE0002518
    TargetHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

    Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA).

    Polypeptides: tRNA (cytidine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferaseSynonyms: tRNA (cytidine(34)-2'-O)-methyltransferase, tRNA (cytidine/uridine-2'-O-)-methyltransferase
  9. Target

    Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

    go.drugbank.com/bio_entities/BE0018277
    TargetHumans

    Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). … Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity)

    Polypeptides: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1Synonyms: Leucine-rich repeat and immunoglobulin domain-containing protein 1
  10. Target

    Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

    go.drugbank.com/bio_entities/BE0002505
    TargetHelicobacter pylori (strain ATCC 700392 / 26695)

    Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

    Polypeptides: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseFunction: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity