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Spermidine/spermine N(1)-acetyltransferase
go.drugbank.com/bio_entities/BE0001716TargetBacillus subtilis (strain 168)Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. … Could also be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase.
Synonyms: Protease synthase and sporulation negative regulatory protein PAI 1Cell growth-regulating nucleolar protein
go.drugbank.com/bio_entities/BE0008958TargetMousePlays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity). … Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (By similarity).
Synonyms: Protein expressed in male leptotene and zygotene spermatocytes 264Zinc transporter ZIP5
go.drugbank.com/bio_entities/BE0009888TransporterHumansThe transport mechanism is temperature- and concentration-dependent and saturable (By similarity). In addition, is also a high affinity copper transporter in vitro (PubMed:36454509). … Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine
Synonyms: Zrt- and Irt-like protein 5Stabilin-2
go.drugbank.com/bio_entities/BE0004948TargetHumansBinds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. … The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS
Synonyms: FAS1 EGF-like and X-link domain-containing adhesion molecule 2, Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2Prolyl 3-hydroxylase 1
go.drugbank.com/bio_entities/BE0002202TargetEnzymeHumansHas prolyl 3-hydroxylase activity and catalyzes the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in pro-collagen chains, a critical step for the formation of mature collagen
Synonyms: Leucine- and proline-enriched proteoglycan 1Zinc transporter ZIP11
go.drugbank.com/bio_entities/BE0009906TransporterHumansZinc importer that regulates cytosolic zinc concentrations either via zinc influx from the extracellular compartment or efflux from intracellular organelles such as Golgi apparatus. May transport copper ions as well. The transport mechan...
Synonyms: Zrt- and Irt-like protein 11Protein phosphatase 1 regulatory subunit 15A
go.drugbank.com/bio_entities/BE0011888TargetHumansPlays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux (PubMed:32978159). … Also acts a viral restriction factor by attenuating HIV-1 and influenza A virus replication (PubMed:31778897, PubMed:41747053).
Synonyms: Growth arrest and DNA damage-inducible protein GADD34Extracellular sulfatase Sulf-2
go.drugbank.com/bio_entities/BE0016611TargetHumansExhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:30788513, PubMed:35294879).
Polypeptides: Extracellular sulfatase Sulf-2Alpha-2-macroglobulin
go.drugbank.com/bio_entities/BE0000910TargetCarrierHumansFollowing cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
go.drugbank.com/bio_entities/BE0000931TargetHumansHas ADP-ribosyltransferase activity toward GLP1R
Synonyms: ADP-ribosyltransferase C2 and C3 toxin-like 1