Search

Displaying results 81 - 90 of 7187 in total
  1. Target

    Protein C-ets-1

    go.drugbank.com/bio_entities/BE0012759
    TargetHumans

    Transcription factor (PubMed:10698492, PubMed:11909962). Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts (PubMed:20378371). May control the differentiation, survival and p...

    Polypeptides: Protein C-ets-1
  2. Target

    Aurora kinase C

    go.drugbank.com/bio_entities/BE0004601
    TargetHumans

    Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228' … Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.

    Polypeptides: Aurora kinase CSynonyms: Serine/threonine-protein kinase aurora-C, Aurora/IPL1/Eg2 protein 2
  3. Target

    Protein kinase C epsilon type

    go.drugbank.com/bio_entities/BE0003431
    TargetHumans

    Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). … Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein.

    Polypeptides: Protein kinase C epsilon typeFunction: 14-3-3 protein binding
  4. Target

    Vitamin K-dependent protein C

    go.drugbank.com/bio_entities/BE0000380
    TargetEnzymeHumans

    Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265, PubMed:39880037

    Polypeptides: Vitamin K-dependent protein CSynonyms: Anticoagulant protein C
  5. Drug

    Somatrogon

    go.drugbank.com/drugs/DB14960
    ApprovedInvestigational

    [A241515,L39362] The glycosylation and the presence of CTPs in the protein sequence prolongs the half-life of somatrogon and allows its once-weekly dosing. … C-terminus of human growth hormone.

    Categories: Amino Acids, Peptides, and ProteinsSynonyms: CTP-SOMATROPIN FUSION PROTEIN, SOMATROPIN-CTP FUSION PROTEIN
  6. Target

    Protein kinase C iota type

    go.drugbank.com/bio_entities/BE0003889
    TargetHumans

    Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. … In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step.

    Polypeptides: Protein kinase C iota typeSynonyms: Atypical protein kinase C-lambda/iota
  7. Target

    Protein kinase C delta type

    go.drugbank.com/bio_entities/BE0002417
    TargetHumans

    Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein … The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity).

    Polypeptides: Protein kinase C delta typeSynonyms: Tyrosine-protein kinase PRKCD
  8. Target

    Protein kinase C zeta type

    go.drugbank.com/bio_entities/BE0009589
    TargetHumans

    Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved … Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231)

    Polypeptides: Protein kinase C zeta type
  9. Target

    Protein kinase C gamma type

    go.drugbank.com/bio_entities/BE0009588
    TargetHumans

    Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). … Acts as a regulator of dopamine signaling by mediating constitutive phosphorylation of dopamine receptor DRD1, inhibiting G protein-coupled receptor signaling (PubMed:20969574)

    Polypeptides: Protein kinase C gamma type
  10. Target

    Protein kinase C theta type

    go.drugbank.com/bio_entities/BE0001385
    TargetHumans

    Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231) … Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation

    Polypeptides: Protein kinase C theta type