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Displaying results 81 - 90 of 296 in total
  1. Target

    Sodium/potassium-transporting ATPase subunit alpha-3

    go.drugbank.com/bio_entities/BE0005047
    TargetTransporterHumans

    In the brain, ATP1A3 is critical for neuronal cell signaling and for maintenance of electrochemical stability, enabling cell excitation and action potential propagation (PubMed:33880529, PubMed:36075933 … Neuron-specific alpha catalytic component of the Na(+)/K(+)-transporting ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed

    Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-3Synonyms: Sodium pump subunit alpha-3
  2. Target

    Sodium-coupled neutral amino acid symporter 1

    go.drugbank.com/bio_entities/BE0009870
    TransporterHumans

    Symporter that cotransports short-chain neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10891391, PubMed:20599747). … The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391).

    Polypeptides: Sodium-coupled neutral amino acid symporter 1
  3. Target

    Sodium-coupled neutral amino acid symporter 2

    go.drugbank.com/bio_entities/BE0009871
    TransporterHumans

    The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. … Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10930503, PubMed:15774260, PubMed:15922329, PubMed:16621798

    Polypeptides: Sodium-coupled neutral amino acid symporter 2
  4. Target

    Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

    go.drugbank.com/bio_entities/BE0004631
    TargetHumans

    Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). … Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity).

    Polypeptides: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
  5. Target

    Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

    go.drugbank.com/bio_entities/BE0010899
    TargetHumans

    Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions (PubMed:15351778, PubMed:28086084). Displays lower selectivity for K(+) over Na(+) ions (PubMed:28086084). … Contributes to the native pacemaker currents in heart (If) and in the generation of the I(h) current which controls neuron excitability (PubMed:29936235, PubMed:30351409).

    Polypeptides: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
  6. Target

    Sodium-dependent neutral amino acid transporter B(0)AT1

    go.drugbank.com/bio_entities/BE0015577
    TransporterTargetHumans

    This uptake is sodium-dependent and chloride-independent (PubMed:15286787, PubMed:15286788, PubMed:19185582). … Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:18424768, PubMed:19185582)

    Polypeptides: Sodium-dependent neutral amino acid transporter B(0)AT1
  7. Target

    Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

    go.drugbank.com/bio_entities/BE0020615
    TargetHumans

    Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions, with an about 3:1 preference for potassium ions (PubMed:16043489). … Contributes to the native pacemaker currents in heart (If) and in neurons (Ih).

    Polypeptides: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
  8. Target

    Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

    go.drugbank.com/bio_entities/BE0021454
    TargetHumans

    Hyperpolarization-activated ion channel that are permeable to Na(+) and K(+) ions with very slow activation and inactivation (PubMed:10228147, PubMed:10430953, PubMed:20829353).

    Polypeptides: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
  9. Target

    Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

    go.drugbank.com/bio_entities/BE0001300
    TargetHumans

    May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K

    Polypeptides: Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
  10. Target

    B- and T-lymphocyte attenuator

    go.drugbank.com/bio_entities/BE0010629
    TargetHumans

    Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). … In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state.

    Polypeptides: B- and T-lymphocyte attenuatorSynonyms: B- and T-lymphocyte-associated protein