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Displaying results 81 - 90 of 178 in total
  1. Target

    Serine protease HTRA1

    go.drugbank.com/bio_entities/BE0017623
    TargetHumans

    Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members.

  2. Target

    Target of rapamycin complex 2 subunit MAPKAP1

    go.drugbank.com/bio_entities/BE0018900
    TargetHumans

    The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton,

  3. Target

    Transient receptor potential cation channel subfamily M member 5

    go.drugbank.com/bio_entities/BE0020643
    TargetHumans

    Involved in insulin secretion by pancreatic beta cells (By similarity)

  4. Target

    Glutamate dehydrogenase 1, mitochondrial

    go.drugbank.com/bio_entities/BE0000180
    TargetEnzymeHumans

    Plays a role in insulin homeostasis (PubMed:11297618, PubMed:9571255).

  5. Target

    Follicle-stimulating hormone receptor

    go.drugbank.com/bio_entities/BE0000387
    TargetHumans

    Regulates glucose-stimulated insulin secretion in pancreatic beta-cells in a bell curve manner, with moderate FSH levels promoting insulin secretion via Galphas/cAMP/PKA pathways while high FSH levels

  6. Target

    Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

    go.drugbank.com/bio_entities/BE0000457
    TargetHumans

    Appears to modulate insulin sensitivity and function (PubMed:10615944). Also involved in melanogenesis (PubMed:28964717).

  7. Target

    Alpha-2B adrenergic receptor

    go.drugbank.com/bio_entities/BE0000572
    TargetHumans

    Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release (PubMed:2164221).

  8. Target

    Free fatty acid receptor 1

    go.drugbank.com/bio_entities/BE0000688
    TargetHumans

    Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1).

  9. Target

    G protein-activated inward rectifier potassium channel 2

    go.drugbank.com/bio_entities/BE0001030
    TargetHumans

    This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G protein-coupled receptors

  10. Target

    RAC-beta serine/threonine-protein kinase

    go.drugbank.com/bio_entities/BE0001172
    TargetHumans

    Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. … Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like