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Displaying results 901 - 910 of 10000 in total
  1. Drug

    Bezlotoxumab

    go.drugbank.com/drugs/DB13140
    Approved

    [L46976] On November 22, 2016, the Committee for Medicinal Products for Human Use of the European Medicines Agency recommended the granting of a marketing authorization. … [A260106] The drug was granted full approval by the EMA on January 18, 2017.[L47191]

  2. Drug

    Daridorexant

    go.drugbank.com/drugs/DB15031
    ApprovedInvestigational

    [A244280] Daridorexant was approved by the European Commission on May 3, 2022, as the first dual orexin receptor antagonist approved in the market,[L41725] and by Health Canada on April 26, 2023. … Daridorexant reduces overactive wakefulness: in the investigational trials, daridorexant reportedly improved sleep and daytime functioning in patients with insomnia.

  3. Drug

    Ondansetron

    go.drugbank.com/drugs/DB00904
    ApprovedInvestigationalWithdrawn

    and use, including the development of orally soluble films that are both discreet in administration and less of a burden in comparison to having patients attempt to swallow pills during emesis. … Having been developed in the 1980s by GlaxoSmithKline and approved by the US FDA since January 1991, ondansetron has demonstrated a long history of use and efficacy.

    Products: ONDANSETRON EG, EURODAN
  4. Target

    ATP synthase F(1) complex subunit delta, mitochondrial

    go.drugbank.com/bio_entities/BE0000484
    TargetEnzymeHumans

    ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). … Subunit delta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated

    Polypeptides: ATP synthase F(1) complex subunit delta, mitochondrial
  5. Target

    Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

    go.drugbank.com/bio_entities/BE0001298
    TargetAzotobacter vinelandii

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

    Polypeptides: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complexSynonyms: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
  6. Target

    ATP synthase F(1) complex subunit alpha, mitochondrial

    go.drugbank.com/bio_entities/BE0003840
    TargetHumans

    ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). … Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated

    Polypeptides: ATP synthase F(1) complex subunit alpha, mitochondrial
  7. Target

    Actin-related protein 2/3 complex subunit 1B

    go.drugbank.com/bio_entities/BE0004249
    TargetHumans

    Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). … The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079).

    Polypeptides: Actin-related protein 2/3 complex subunit 1BSynonyms: Arp2/3 complex 41 kDa subunit
  8. Target

    Actin-related protein 2/3 complex subunit 3

    go.drugbank.com/bio_entities/BE0004253
    TargetHumans

    Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). … The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079).

    Polypeptides: Actin-related protein 2/3 complex subunit 3Synonyms: Arp2/3 complex 21 kDa subunit
  9. Target

    ATP synthase F(0) complex subunit g, mitochondrial

    go.drugbank.com/bio_entities/BE0009022
    TargetHumans

    Part of the complex F(0) domain (PubMed:37244256) … ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256).

    Polypeptides: ATP synthase F(0) complex subunit g, mitochondrial
  10. Indication

    B Vitamin Deficiency

    go.drugbank.com/conditions/DBCOND0067035
    Drugs: Flavin mononucleotide · Hydroxocobalamin · Riboflavin · Saw palmetto
    Synonyms: Vitamin B complex deficiency, B-complex deficiency NOS