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Displaying results 921 - 930 of 10000 in total
  1. Pathway

    Metabolism and Physiological Effects of Phenylacetic Acid

    smpdb.ca/view/SMP0123256
    Metabolic

    It reduces nitric oxide production and reduces protection against inflammation in vessel walls. It also leads to the production of reactive oxygen species. … Coli strain K12 through an unknown transporter. In the periplasm of the E. coli, 2-phenylethylamine is catalyzed by the enzyme primary amine oxidase to synthesize phenylacetaldehyde.

    Drugs: Pyridoxal phosphate · Phenylalanine · NADH · Phenylacetaldehyde · Phenethylamine
  2. Pathway

    Metabolism and Physiological Effects of Orotic acid

    smpdb.ca/view/SMP0124870
    Metabolic

    A build up of orotate in the body leads to acidosis which can have detrimental effects on other systems in the body causing renal failure, neurotoxicity, endothelial dysfunction and hypertension. … It originates from l-glutamine, which is obtained from protein sources such as red meat and eggs in the diet. L-glutamine is metabolized to orotate in the liver.

    Drugs: Aspartic acid · L-Glutamine · ATP · Zinc · Flavin mononucleotide
    Enzymes: CAD protein
  3. Pathway

    Metabolism and Physiological Effects of N-Acetylserine

    smpdb.ca/view/SMP0126556
    Metabolic

    Serine can be obtained from the diet from foods high in protein such as soybeans, nuts, eggs, meat, and fish. … of N-acetylthreonine, N-acetylisoleucine, and N-acetylvaline) can be detected in the urine with individuals with acylase I deficiency, a genetic disorder.

    Drugs: Serine · N-Acetyl-Serine
  4. Pathway

    Metabolism and Physiological Effects of N-Acetylthreonine

    smpdb.ca/view/SMP0126703
    Metabolic

    In addition to the NAT enzymes and protein-based acetylation, N-acetylation of free threonine can also occur. … of N-acetylglutamine, N-acetylisoleucine, and N-acetylvaline) can be detected in the urine with individuals with acylase I deficiency, a genetic disorder.

    Drugs: Threonine
  5. Pathway

    Metabolism and Physiological Effects of N-Acetyltryptophan

    smpdb.ca/view/SMP0126721
    Metabolic

    In addition to the NAT enzymes and protein-based acetylation, N-acetylation of free tryptophan can also occur. … N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins.

    Drugs: Tryptophan
  6. Pathway

    Metabolism and Physiological Effects of Indolelacetyl glutamine

    smpdb.ca/view/SMP0126755
    Metabolic

    Several intestinal bacteria, such as Bacteroides, Clostridia, and E. coli, can catabolize Trp to tryptamine and indole pyruvic acid, which are then converted to indole-3-acetic acid, indole propionic acid … Indoleacetyl glutamine frequently occurs at low levels in urine and has been found in elevated levels in the urine of patients with hartnup disease, the characteristic symptoms of the disease are mental

    Drugs: L-Glutamine · Tryptophan · Indoleacetic acid
  7. Pathway

    Metabolism and Physiological Effects of 3-Methylhistidine

    smpdb.ca/view/SMP0126757
    Metabolic

    Because of its abundance in some muscle-related proteins but especially because of the high abundance of anserine found in poultry and fish, 3MH has been found to be a good biomarker for the consumption … synthesized only in the muscle by the methylation of one histidine residue in actin and in varying amounts in myosin depending on the type of muscle.

    Drugs: Histidine · Ademetionine · Proline
  8. Pathway

    Metabolism and Physiological Effects of O-Sulfotyrosine

    smpdb.ca/view/SMP0126811
    Metabolic

    O-Sulfotyrosine has been identified as a potential plasma biomarker of reduced kidney function in early chronic kidney disease (CKD), end stage renal disease (ESRD), and hemodialytic clearance. … Sulfation is catalyzed by tyrosylprotein sulfotransferase (TPST) in the Golgi apparatus.

    Drugs: Phenylalanine · Tyrosine · Sapropterin · Iron
  9. Pathway

    Metabolism and Physiological Effects of S-Adenosylhomocysteine

    smpdb.ca/view/SMP0127690
    Metabolic

    It is toxic to immature lymphocytes and can lead to immunosuppression. … Therefore, when present in sufficiently high levels, S-adenosylhomocysteine can act as an immunotoxin and a metabotoxin. An immunotoxin disrupts, limits the function, or destroys immune cells.

    Drugs: Ademetionine · Methionine · ATP · Potassium cation · Magnesium cation · Pyrophosphoric acid
  10. Drug

    Tigecycline

    go.drugbank.com/drugs/DB00560
    ApprovedInvestigational

    Tigecycline is a glycylcycline antibiotic developed and marketed by Wyeth under the brand name Tygacil. … It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus. It was granted fast-track approval by the U.S.

    Products: TIGESIL-LIYO 50MG IV INFÜZYON IÇIN LIYOFILIZE TOZ IÇEREN FLAKON ,10 FLAKON, TİGELYS 50MG IV İNFÜZYONLUK ÇÖZELTİ İÇİN LİYOFİLİZE TOZ İÇEREN FLAKON, 10 ADET