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Displaying results 931 - 940 of 10000 in total
  1. Pathway

    Vilazodone mechanism of Action Action Pathway

    smpdb.ca/view/SMP0126404
    Drug action

    Vilazodone selectively inhibits serotonin reuptake in the central nervous system as well as acting as a partial agonist of 5HT-1A receptors. The exact mechanism for how these effects translate to its antidepressant effects are not known ...

    Drugs: Pyridoxal phosphate · Tryptophan · Sapropterin · Iron · Oxitriptan · Vilazodone
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
  2. Pathway

    Levodopa Pahway

    smpdb.ca/view/SMP0124684
    Drug action

    Levodopa is a dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. Degeneration of the dopaminergic neurons in substantia nigra o...

    Drugs: Pyridoxal phosphate · ATP · Dopamine · Levodopa · Calcium · Magnesium cation +2 more
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  3. Pathway

    Apomorphine Mechanism of Action Action Pathway

    smpdb.ca/view/SMP0126633
    Drug action

    Apomorphine is a non-ergoline dopamine agonist with high binding affinity to dopamine D2, D3, and D5 receptors. Stimulation of D2 receptors in the caudate-putamen, a region of the brain responsible for locomotor control, may be responsib...

    Drugs: Pyridoxal phosphate · Tyrosine · ATP · Apomorphine · Dopamine · Levodopa +5 more
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  4. Pathway

    Epicriptine Mechanism of Action Action Pathway

    smpdb.ca/view/SMP0126655
    Drug action

    Epicriptine effect is mainly due to the agonistic activity on dopamine receptor. Epicriptine is also known as beta-dihydroergocryptine presents a molecular formula of 9,10 alpha-dihydro-13'-epi-b-ergocryptine. Together with the alpha-dih...

    Drugs: Pyridoxal phosphate · Tyrosine · ATP · Dopamine · Levodopa · Calcium +5 more
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  5. Drug

    Tramadol

    go.drugbank.com/drugs/DB00193
    ApprovedInvestigational

    It is considered a Step 2 option on the World Health Organization's pain ladder and has about 1/10th of the potency of [morphine]. … Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine].

    Mixtures: Skudexa 75 mg/25 mg Granulat im Beutel zur Herstellung einer Lösung zum Einnehmen, DOR-2®Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  6. Pathway

    Dihydroergocryptine Mechanism of Action Action Pathway

    smpdb.ca/view/SMP0126659
    Drug action

    Alpha-dihydroergocryptine is usually referred to the mixture of the alpha and beta dihydroergocryptine. These two compounds are differentiated in the position of a methyl group. This structural difference is due to a proteinogenic amino ...

    Drugs: Pyridoxal phosphate · Tyrosine · ATP · Dopamine · Levodopa · Calcium +5 more
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  7. Pathway

    Ergoloid mesylate Mechanism of Action Action Pathway

    smpdb.ca/view/SMP0126658
    Drug action

    Ergoloid Mesylate is an equiproportional preparation of three different ergotamantriones: dihydroergocornine, dihydroergocristine, and dihydroergocryptine. All these components are produced by the fungus Claviceps purpurea and are all de...

    Drugs: Pyridoxal phosphate · Tyrosine · ATP · Dopamine · Ergoloid mesylate · Levodopa +5 more
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  8. Pathway

    Thiethylperazine Dopamine Antagonist Action Pathway

    smpdb.ca/view/SMP0126476
    Drug action

    Thiethylperazine' s antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors.

    Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Thiethylperazine · Dopamine · Levodopa +2 more
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  9. Pathway

    Megestrol acetate Action Pathway

    smpdb.ca/view/SMP0126528
    Drug action

    Megestrol acetate is a synthetic progestational hormone initially developed as a contraceptive. Nowadays, it is used as a drug to treat anorexia and cachexia (or unexplained weight loss) and as an antineoplastic agent to treat inoperable...

    Drugs: NADH · ATP · Megestrol acetate · Progesterone · Testosterone · Estrone +9 more
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  10. Pathway

    Norelgestromin Action Pathway

    smpdb.ca/view/SMP0126539
    Drug action

    Norelgestromin is a synthetic progestational hormone indicated in women to prevent pregnancy. This drug is also used in menopausal hormonal therapy. This drug is administered as a contraceptive pill or as a transdermal patch. This drug i...

    Drugs: NADH · ATP · Progesterone · Testosterone · Estrone · Potassium cation +9 more
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12