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Thiamine transporter 1
go.drugbank.com/bio_entities/BE0003530TransporterHumansHigh-affinity transporter for the intake of thiamine (PubMed:10391222, PubMed:10542220, PubMed:21836059, PubMed:33008889, PubMed:35512554, PubMed:35724964). Mediates H(+)-dependent pyridoxine transport (PubMed:33008889, PubMed:35512554, ...
Polypeptides: Thiamine transporter 1Synonyms: ThTr-1, Thiamine carrier 1Sphingosine kinase 1
go.drugbank.com/bio_entities/BE0004728EnzymeTargetHumansCatalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. … Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling leading to IL17 secretion (PubMed:20577214).
Polypeptides: Sphingosine kinase 1Synonyms: SK 1, SPK 1Thymidylate synthase 1
go.drugbank.com/bio_entities/BE0004794TargetBacillus subtilis (strain 168)Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and
Polypeptides: Thymidylate synthase 1Synonyms: TS 1DNA topoisomerase 1
go.drugbank.com/bio_entities/BE0004950TargetStaphylococcus aureusThe scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.
Polypeptides: DNA topoisomerase 1Actin, cytoplasmic 1
go.drugbank.com/bio_entities/BE0004966TargetHumansActin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) form...
Polypeptides: Actin, cytoplasmic 1Alpha-1-antichymotrypsin
go.drugbank.com/bio_entities/BE0009090TargetHumansAlthough its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2
Polypeptides: Alpha-1-antichymotrypsinDipeptidyl aminopeptidase 1
go.drugbank.com/bio_entities/BE0009253TargetPlasmodium falciparum (isolate 3D7)Thiol protease that cleaves dipeptides from the N-terminus of protein substrates (PubMed:15304495, PubMed:20833209). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids (PubMed:20833209...
Polypeptides: Dipeptidyl aminopeptidase 1Tripeptidyl-peptidase 1
go.drugbank.com/bio_entities/BE0011158TargetHumansLysosomal serine protease with tripeptidyl-peptidase I activity (PubMed:11054422, PubMed:19038966, PubMed:19038967). May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysoso...
Polypeptides: Tripeptidyl-peptidase 1Synonyms: TPP-1, Cell growth-inhibiting gene 1 proteinCeramide synthase 1
go.drugbank.com/bio_entities/BE0012836EnzymeHumansCeramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA) (PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:3191662...
Polypeptides: Ceramide synthase 1Synonyms: Longevity assurance gene 1 protein homolog 1, Protein UOG-1Phosphatidylcholine:ceramide cholinephosphotransferase 1
go.drugbank.com/bio_entities/BE0016391TargetEnzymeHumansMajor sphingomyelin synthase at the Golgi apparatus (PubMed:14685263, PubMed:17449912). Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group...
Polypeptides: Phosphatidylcholine:ceramide cholinephosphotransferase 1Synonyms: Sphingomyelin synthase 1