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Phospho-2-dehydro-3-deoxyheptonate aldolase
go.drugbank.com/bio_entities/BE0001721TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Catalyzes the condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
Polypeptides: Phospho-2-dehydro-3-deoxyheptonate aldolaseSynonyms: Phospho-2-keto-3-deoxyheptonate aldolaseRibonucleoside-diphosphate reductase 2 subunit alpha
go.drugbank.com/bio_entities/BE0001782TargetSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1E contains the binding sites for both substrates and allosteric effectors and carries out t...
Polypeptides: Ribonucleoside-diphosphate reductase 2 subunit alphaSynonyms: Ribonucleotide reductase 26,7-dimethyl-8-ribityllumazine synthase 2
go.drugbank.com/bio_entities/BE0001793TargetBrucella suis biovar 1 (strain 1330)Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.
Polypeptides: 6,7-dimethyl-8-ribityllumazine synthase 2Synonyms: ribH-2, DMRL synthase 2Multiple coagulation factor deficiency protein 2
go.drugbank.com/bio_entities/BE0002120TargetHumansThe MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors
Polypeptides: Multiple coagulation factor deficiency protein 2Interleukin-13 receptor subunit alpha-2
go.drugbank.com/bio_entities/BE0002421TargetHumansCell surface receptor that plays a role in the regulation of IL-13-mediated responses (PubMed:11861389, PubMed:17030238). Functions as a decoy receptor that inhibits IL-13- and IL-4-mediated signal transduction via the JAK-STAT pathway a...
Polypeptides: Interleukin-13 receptor subunit alpha-2Synonyms: IL-13R-alpha-2, IL-13R subunit alpha-2Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
go.drugbank.com/bio_entities/BE0003477TargetTransporterHumansThis magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:12542527, PubMed:16402920). Involved in autophagy in response to starv...
Polypeptides: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Synonyms: SR Ca(2+)-ATPase 2, Endoplasmic reticulum class 1/2 Ca(2+) ATPaseSodium channel regulatory subunit beta-2
go.drugbank.com/bio_entities/BE0003636TargetHumansRegulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes (PubMed:19808477, PubMed:23559163, PubMed:26894959, PubMed:30765605, PubMed:30765606, PubMed:35277491, PubMed...
Polypeptides: Sodium channel regulatory subunit beta-2Mannan-binding lectin serine protease 2
go.drugbank.com/bio_entities/BE0004630TargetHumansPrecursor of a serum protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:11527...
Polypeptides: Mannan-binding lectin serine protease 2Synonyms: MASP-2, MBL-associated serine protease 2Proton-coupled amino acid transporter 2
go.drugbank.com/bio_entities/BE0004704TransporterHumansElectrogenic proton/amino acid symporter with a high selectivity for the small side chains amino acids glycine, alanine and proline, where both L- and D-enantiomers are transported. Extension of the backbone length, as in beta-alanine an...
Polypeptides: Proton-coupled amino acid transporter 2Synonyms: Proton/amino acid transporter 2, Solute carrier family 36 member 2Natural resistance-associated macrophage protein 2
go.drugbank.com/bio_entities/BE0008685TransporterTargetHumansSelectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (PubMed:17109629, PubMed:17293870, PubMed:22736759, PubMed:25326704 … Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity).
Polypeptides: Natural resistance-associated macrophage protein 2Synonyms: NRAMP 2, Solute carrier family 11 member 2