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Bone morphogenetic protein receptor type-1B
go.drugbank.com/bio_entities/BE0009415TargetHumansReceptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction … On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.
Polypeptides: Bone morphogenetic protein receptor type-1BSynonyms: BMP type-1B receptorInterleukin-1 receptor-associated kinase 1
go.drugbank.com/bio_entities/BE0009452TargetHumansInvolved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation.
Polypeptides: Interleukin-1 receptor-associated kinase 1Receptor tyrosine-protein kinase erbB-3
go.drugbank.com/bio_entities/BE0009917TargetHumansTyrosine kinase receptor that, despite substitutions of key catalytic residues in the kinase domain, retains residual catalytic activity enabling autophosphorylation (PubMed:9148746, PubMed:20351256).
Polypeptides: Receptor tyrosine-protein kinase erbB-3Synonyms: Tyrosine kinase-type cell surface receptor HER3Advanced glycation end product-specific receptor
go.drugbank.com/bio_entities/BE0010032TransporterTargetHumansCell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein
Polypeptides: Advanced glycation end product-specific receptorSynonyms: Receptor for advanced glycation end products, Advanced glycosylation end product-specific receptorHepatitis A virus cellular receptor 2
go.drugbank.com/bio_entities/BE0010551TargetHumansReceptor for LGALS9 (PubMed:16286920, PubMed:24337741). … However, the function as receptor for LGALS9 has been challenged (PubMed:23555261).
Polypeptides: Hepatitis A virus cellular receptor 2Synonyms: T-cell immunoglobulin mucin receptor 3Baculoviral IAP repeat-containing protein 7
go.drugbank.com/bio_entities/BE0010707TargetHumansApoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control (PubMed:11024045, PubMed:11084335, PubMed:11162435, PubMed:16729033, PubM...
Polypeptides: Baculoviral IAP repeat-containing protein 7C-C chemokine receptor type 3
go.drugbank.com/bio_entities/BE0013339TargetHumansMay also act as a possible functional receptor for NARS1 (PubMed:30171954) … G protein-coupled receptor (GPCR) that plays a key role in the immune system by regulating the migration and activation of white blood cells in response to chemokines (PubMed:28994588).
Polypeptides: C-C chemokine receptor type 3Synonyms: Eosinophil eotaxin receptorC-C chemokine receptor type 8
go.drugbank.com/bio_entities/BE0013343TargetHumansG protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18 (PubMed:23999500, PubMed:35041514). Regulates monocyte and eosinophil chemotaxis.
Polypeptides: C-C chemokine receptor type 8Synonyms: Chemokine receptor-like 1, CC chemokine receptor CHEMR1Oncostatin-M-specific receptor subunit beta
go.drugbank.com/bio_entities/BE0018846TargetHumansFunctions as a shared membrane-bound signal-transducing subunit in two distinct receptor complexes, the type II OSM receptor (heterodimer composed of OSMR and IL6ST) and the IL31 receptor complex (heterodimer … In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (PubMed:15627637)
Polypeptides: Oncostatin-M-specific receptor subunit betaSynonyms: IL-31 receptor subunit beta, Interleukin-31 receptor subunit betaTaste receptor type 2 member 4
go.drugbank.com/bio_entities/BE0020472TargetHumansGustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.
Polypeptides: Taste receptor type 2 member 4Function: bitter taste receptor activity