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Displaying results 951 - 960 of 1711 in total
  1. Target

    Non-receptor tyrosine-protein kinase TYK2

    go.drugbank.com/bio_entities/BE0004146
    TargetHumans

    The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 … Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR

    Polypeptides: Non-receptor tyrosine-protein kinase TYK2
  2. Target

    Interleukin-1 receptor-associated kinase 4

    go.drugbank.com/bio_entities/BE0004344
    TargetHumans

    Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). … Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2.

    Polypeptides: Interleukin-1 receptor-associated kinase 4
  3. Target

    Adhesion G protein-coupled receptor D1

    go.drugbank.com/bio_entities/BE0005510
    TargetHumans

    Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength (PubMed:39884271) … Adhesion G protein-coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens (PubMed

    Polypeptides: Adhesion G protein-coupled receptor D1Synonyms: G protein-coupled receptor 133, G protein-coupled receptor PGR25
  4. Target

    Signal recognition particle receptor subunit beta

    go.drugbank.com/bio_entities/BE0009230
    TargetPlasmodium falciparum (isolate 3D7)

    Polypeptides: Signal recognition particle receptor subunit betaSynonyms: Signal recognition particle receptor, beta subunit
  5. Target

    Tyrosine-protein kinase receptor Tie-1

    go.drugbank.com/bio_entities/BE0009396
    TargetHumans

    Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis

    Polypeptides: Tyrosine-protein kinase receptor Tie-1
  6. Target

    Interleukin-1 receptor-associated kinase 3

    go.drugbank.com/bio_entities/BE0009453
    TargetHumans

    Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity).

    Polypeptides: Interleukin-1 receptor-associated kinase 3Synonyms: IL-1 receptor-associated kinase M, Inactive IL-1 receptor-associated kinase 3
  7. Target

    C-C chemokine receptor type 4

    go.drugbank.com/bio_entities/BE0009787
    TargetHumans

    High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. … The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system.

    Polypeptides: C-C chemokine receptor type 4
  8. Target

    Killer cell immunoglobulin-like receptor 2DL3

    go.drugbank.com/bio_entities/BE0010665
    TargetHumans

    Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis

    Polypeptides: Killer cell immunoglobulin-like receptor 2DL3Synonyms: p58 NK receptor CL-6, Killer inhibitory receptor cl 2-3
  9. Target

    Baculoviral IAP repeat-containing protein 3

    go.drugbank.com/bio_entities/BE0010674
    TargetHumans

    Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 u...

    Polypeptides: Baculoviral IAP repeat-containing protein 3
  10. Target

    Baculoviral IAP repeat-containing protein 2

    go.drugbank.com/bio_entities/BE0010675
    TargetHumans

    Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ...

    Polypeptides: Baculoviral IAP repeat-containing protein 2