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Selexipag Action Pathway
smpdb.ca/view/SMP0126508Drug actionSelexipag is a non-prostanoid prostacyclin receptor agonist, also known as Uptravi typically used to treat pulmonary arterial hypertension. Selexipag is a selective prostacyclin receptor agonist, it is administered orally and is metaboli...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Hydroxypropyl cellulose
go.drugbank.com/drugs/DB00840ApprovedAs a food additive, hydroxypropyl cellulose is used as a thickener and as an emulsion stabilizer. … , and as a lubricant for artificial eyes.
Categories: Compounds used in a research, industrial, or household settingSynonyms: Cellulose, 2-hydroxypropyl ether, Hydroxypropyl cellulose (type H)Diclofenamide
go.drugbank.com/drugs/DB01144ApprovedA carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
Synonyms: 4,5-dichloro-m-benzenedisulfonamide, 3,4-dichloro-5-sulfamylbenzenesulfonamideGestrinone
go.drugbank.com/drugs/DB11619ApprovedGestrinone was developed in the early 1970s and was tested clinically as a weekly oral contraceptive in Europe and North America. … Gestrinone, also known as ethylnorgestrienone, is a synthetic steroid of the 19-nortestosterone group that is marketed in Europe, Australia, and Latin America, though not the United States or Canada, and
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesDopamine
go.drugbank.com/drugs/DB00988ApprovedInvestigationalIt is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. … A family of receptors (receptors, dopamine) mediate its action.
Mixtures: Dopamine HCl 3.2mg/ml Dextrose 5% Inj USP, Dopamine HCl 1.6mg/ml Dextrose 5% Inj USPCategories: Monoamine Oxidase A Substrates, Selective Beta 1-adrenergic AgonistsFutibatinib
go.drugbank.com/drugs/DB15149ApprovedInvestigational[L43347] On July 4, 2023, the European Commission granted Conditional Marketing Authorization for futibatinib for the treatment of cholangiocarcinoma.[L47800] … FGFR was investigated in oncology as a therapeutic target, as FGFR genomic aberrations and dysregulated FGFR signalling pathways are observed in some cancers such as cholangiocarcinoma and urothelial malignancies
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: 1-((3S)-(4-amino-3-((3,5-dimethoxyphenyl)ethynyl)-1H-pyrazolo(3, 4-d) pyrimidin-1-yl)-1-pyrrolidinyl)-2-propen-1-one, 1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-oneSelenoamino Acid Metabolism
smpdb.ca/view/SMP0000029MetabolicPhospholipids are membrane components in P. aeruginosa. The major phospholipids of P. aeruginosa are phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin. All phospholipids contain sn-glycerol-3-phosphate esterified with fatty...
Enzymes: S-adenosylmethionine synthase isoform type-2Eteplirsen
go.drugbank.com/drugs/DB06014ApprovedInvestigationalEteplirsen is a synthetic antisense oligonucleotide and a phosphorodiamidate morpholino oligomer. … is amenable to exon 51 skipping.
Synonyms: (P-deoxy-P-(dimethylamino)](2',3'-dideoxy-2',3'-imino-2',3'-seco)(2'a→5')(C-m5U-C-C-A-A-C-A-m5U-C-A-A-G-G-A-A-G-A-m5U-G-G-C-A-m5U-m5U-m5U-C-m5U-A-G),5'-(P-(4-((2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)carbonyl, )-1-piperazinyl)-N,N-dimethylphosphonamidate) RNACategories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingTecovirimat
go.drugbank.com/drugs/DB12020ApprovedInvestigationalHowever, there have been longstanding concerns that smallpox may be used as a bioweapon.[A35133,L3614] Tecovirimat is an antiviral drug that was identified via a high-throughput screen in 2002. … [L40154] Tecovirimat is available as both oral and intravenous formulations.[L41835]
Synonyms: ST-246Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 CYP3A InducersGq Adrenergic Smooth Muscle Contraction
smpdb.ca/view/SMP0126882PhysiologicalGq protein alpha subunit is a family of heterotrimeric G protein alpha subunits. This family is also commonly called the Gq/11 (Gq/G11) family or Gq/11/14/15 family to include closely related family members. G alpha subunits may be refer...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short