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Displaying results 961 - 970 of 3388 in total
  1. Target

    Gamma-aminobutyric acid receptor subunit alpha-4

    go.drugbank.com/bio_entities/BE0000478
    TargetHumans

    Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020). GABA-gated chloride channels, also named GABA(A) receptors (...

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-4Synonyms: GABA(A) receptor subunit alpha-4
  2. Target

    Receptor-interacting serine/threonine-protein kinase 4

    go.drugbank.com/bio_entities/BE0009533
    TargetHumans

    Serine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By s...

    Polypeptides: Receptor-interacting serine/threonine-protein kinase 4Synonyms: Ankyrin repeat domain-containing protein 3
  3. Target

    C-X-C chemokine receptor type 4

    go.drugbank.com/bio_entities/BE0000919
    TargetHumans

    Also acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). … Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10074102, PubMed:10452968, PubMed:10644702

    Polypeptides: C-X-C chemokine receptor type 4Synonyms: SDF-1 receptor, Stromal cell-derived factor 1 receptor
  4. Target

    Receptor-interacting serine/threonine-protein kinase 1

    go.drugbank.com/bio_entities/BE0009531
    TargetHumans

    Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:17703191, PubMed:24144979, PubMed:31827280, PubMed:31827281, PubMed:32657447, PubMed:35831301). Exhibits kinase act...

    Polypeptides: Receptor-interacting serine/threonine-protein kinase 1Synonyms: Receptor-interacting protein 1
  5. Target

    Mast/stem cell growth factor receptor Kit

    go.drugbank.com/bio_entities/BE0000453
    TargetHumans

    KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. … Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance

    Polypeptides: Mast/stem cell growth factor receptor Kit
  6. Target

    Tyrosine-protein phosphatase non-receptor type 1

    go.drugbank.com/bio_entities/BE0000623
    TargetHumans

    May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET

    Polypeptides: Tyrosine-protein phosphatase non-receptor type 1
  7. Target

    Prolow-density lipoprotein receptor-related protein 1

    go.drugbank.com/bio_entities/BE0002110
    TargetHumans

    Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:1702392, PubMed:26142438). … Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (PubMed:9252371)

    Polypeptides: Prolow-density lipoprotein receptor-related protein 1Synonyms: Apolipoprotein E receptor, Alpha-2-macroglobulin receptor
  8. Target

    Calcitonin gene-related peptide type 1 receptor

    go.drugbank.com/bio_entities/BE0009009
    TargetHumans

    G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs) (PubMed:32296767, PubMed:33602864, PubMed:8626685). … Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2 (PubMed:33602864).

    Polypeptides: Calcitonin gene-related peptide type 1 receptorSynonyms: Calcitonin receptor-like receptor, CGRP type 1 receptor
  9. Target

    Gamma-aminobutyric acid receptor subunit gamma-3

    go.drugbank.com/bio_entities/BE0003594
    TargetHumans

    Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GA...

    Polypeptides: Gamma-aminobutyric acid receptor subunit gamma-3Synonyms: GABA(A) receptor subunit gamma-3
  10. Target

    F-box/WD repeat-containing protein 1A

    go.drugbank.com/bio_entities/BE0021224
    TargetHumans

    SCF(BTRC) directs 'Lys-48'-linked ubiquitination of UBR2 in the T-cell receptor signaling pathway (PubMed:38225265)

    Polypeptides: F-box/WD repeat-containing protein 1ASynonyms: pIkappaBalpha-E3 receptor subunit