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Displaying results 1 - 10 of 184 in total
  1. Target

    Chloride anion exchanger

    go.drugbank.com/bio_entities/BE0010211
    TransporterHumans

    Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity) … Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:16606687, PubMed:19321737, PubMed:22159084, PubMed:22627094).

    Polypeptides: Chloride anion exchanger
  2. Target

    Sodium- and chloride-dependent betaine transporter

    go.drugbank.com/bio_entities/BE0004777
    TargetTransporterHumans

    Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (PubMed:7589472). … Probably also involved in renal and hepatic osmotic regulation (By similarity)

    Polypeptides: Sodium- and chloride-dependent betaine transporter
  3. Target

    Sodium- and chloride-dependent taurine transporter

    go.drugbank.com/bio_entities/BE0009148
    TransporterHumans

    Mediates sodium- and chloride-dependent transport of taurine, a key amino acid (PubMed:31345061, PubMed:31903486, PubMed:39837997, PubMed:40108165, PubMed:40108449, PubMed:40615403, PubMed:40789850, PubMed … Taurine acts as an anti-aging agent by reducing cellular senescence and combating oxidative stress: levels decline with age and supplementation has been shown to extend lifespan (By similarity).

    Polypeptides: Sodium- and chloride-dependent taurine transporter
  4. Target

    Sodium- and chloride-dependent glycine transporter 1

    go.drugbank.com/bio_entities/BE0000940
    TransporterTargetHumans

    Sodium- and chloride-dependent glycine transporter (PubMed:37962965, PubMed:8183239). Essential for regulating glycine concentrations at inhibitory glycinergic synapses

    Polypeptides: Sodium- and chloride-dependent glycine transporter 1
  5. Target

    Sodium- and chloride-dependent glycine transporter 2

    go.drugbank.com/bio_entities/BE0002310
    TransporterTargetHumans

    Sodium- and chloride-dependent glycine transporter (PubMed:10381548, PubMed:10606742, PubMed:16751771, PubMed:31370103, PubMed:9845349).

    Polypeptides: Sodium- and chloride-dependent glycine transporter 2
  6. Target

    Chloride channel protein 2

    go.drugbank.com/bio_entities/BE0000765
    TargetHumans

    In glia, associates with the auxiliary subunit HEPACAM/GlialCAM at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux buffering extracellular chloride and … In hippocampal neurons, generates a significant part of resting membrane conductance and provides an additional chloride efflux pathway to prevent chloride accumulation in dendrites upon GABA receptor

    Polypeptides: Chloride channel protein 2Function: chloride channel regulator activity
  7. Target

    Sodium- and chloride-dependent GABA transporter 1

    go.drugbank.com/bio_entities/BE0000249
    TargetHumans

    Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:30132828). … Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (By similarity)

    Polypeptides: Sodium- and chloride-dependent GABA transporter 1
  8. Target

    Sodium- and chloride-dependent creatine transporter 1

    go.drugbank.com/bio_entities/BE0000375
    TargetTransporterHumans

    Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity)

    Polypeptides: Sodium- and chloride-dependent creatine transporter 1
  9. Target

    Sodium- and chloride-dependent GABA transporter 2

    go.drugbank.com/bio_entities/BE0004776
    TargetHumans

    Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:17502375, PubMed:22932902). Mediates transport of beta-alanine (PubMed:17502375). … Can also mediate transport of taurine and hypotaurine (By similarity)

    Polypeptides: Sodium- and chloride-dependent GABA transporter 2
  10. Target

    Glutamate-gated chloride channel

    go.drugbank.com/bio_entities/BE0009555
    TargetOnchocerca volvulus

    Polypeptides: Glutamate-gated chloride channelFunction: chloride channel activity