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Indomethacin Action Pathway
smpdb.ca/view/SMP0000104Drug actionIndomethacin (also named Amuno or Indocid) is a nonsteroidal anti-inflammatory drug (NSAID). It can be used to treat prostaglandin G/H synthase related fever, swelling, pain and inflammation. Indomethacin can block prostaglandin synthesi...
Drugs: Glutamic acid · Glutathione · Indomethacin · Dinoprostone · Calcium · Magnesium cation +5 moreIndomethacin NSAID Action Pathway
smpdb.ca/view/SMP0124592Drug actionIndomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. It ...
Acemetacin Action Pathway
smpdb.ca/view/SMP0126084Drug actionAcemetacin is highly metabolized and degraded by esterolytic cleavage to form its major and active metabolite indometacin. Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for the symptomatic management of chronic musculoske...
Disulfiram Action Pathway
smpdb.ca/view/SMP0000429Drug actionDisulfiram is a drug used in the treatment of cocaine addiction and chronic alcoholism. With regards to cocaine addiction, cocaine inhibits dopamine reuptake by blocking dopamine transporter 1 (DAT1). This increases dopamine concentratio...
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Adenosine phosphate · Tyrosine +27 moreEthanol GABA Agonist Action Pathway
smpdb.ca/view/SMP0125151Drug actionEthanol, commonly seen in the form of various alcohols as well as hand sanitizer, is a drug that is injected intrathecally. Ethanol's effects are mainly seen in the brain where it binds to many receptors. The main effects are seen by the...
Cocaine metabolism
smpdb.ca/view/SMP0125265MetabolicCocaine is a local anaesthetic used for diagnostic procedures or surgery on or through the nasal cavity. It is administered as a spray in the nose where it enters the blood vessels of the nose and travels through the body. When taken ill...
Pentosan polysulfate Drug Metabolism
smpdb.ca/view/SMP0130719MetabolicPentosan polysulfate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Pentosan polysulfate passes through the liver and is then excreted from the body mainly through the k...
Drugs: Pentosan polysulfateEthanol Degradation
smpdb.ca/view/SMP0000449MetabolicEthanol metabolism in humans occurs mainly in the liver, though degradation has also been shown in gastric, pancreatic, and lung tissue. Ethanol degradation occurs via four pathways, three of which are oxidative pathways and are depicted...
Disulfiram Aldehyde Dehydrogenase Inhibitor Action Pathway
smpdb.ca/view/SMP0122693Drug actionDisulfiram is a carbamate derivative used to treat chronic alcoholism. It irreversibly inhibits aldehyde dehydrogenase in the mitochondrial matrix which converts acetaldehyde to acetic acid causing an accumulation of acetaldehyde. The hi...
Lamotrigine Action Pathway
smpdb.ca/view/SMP0126274Drug actionLamotrigine is a phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder. It can be found under the brand name Lamictal. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar di...