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Displaying results 1 - 10 of 12 in total
  1. Target

    Folic acid synthesis protein FOL1

    go.drugbank.com/bio_entities/BE0004658
    TargetBaker's yeast

    Catalyzes three sequential steps of tetrahydrofolate biosynthesis.

    Polypeptides: Folic acid synthesis protein FOL1
  2. Target

    Folate receptor beta

    go.drugbank.com/bio_entities/BE0000271
    TargetTransporterHumans

    Has high affinity for folate and folic acid analogs at neutral pH. … Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells.

    Function: folic acid binding
  3. Target

    Folate receptor alpha

    go.drugbank.com/bio_entities/BE0003405
    TargetTransporterHumans

    Has high affinity for folate and folic acid analogs at neutral pH (PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). … Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:19074442, PubMed:23851396, PubMed:23934049, PubMed

    Function: folic acid binding
  4. Target

    Folate receptor gamma

    go.drugbank.com/bio_entities/BE0000652
    TargetHumans

    Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate

    Function: folic acid binding
  5. Target

    Folate receptor

    go.drugbank.com/bio_entities/BE0010260
    TransporterTargetHumans

    Has high affinity for folate and folic acid analogs at neutral pH. … Has high affinity for folate and folic acid analogs at neutral pH (PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728).

    Function: folic acid binding, folic acid binding
  6. Target

    Proton-coupled folate transporter

    go.drugbank.com/bio_entities/BE0001048
    TransporterTargetHumans

    Functions at acidic pH via alternate outward- and inward-open conformation states (PubMed:32893190, PubMed:34040256). … Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes (PubMed:19074442).

    Function: folic acid transmembrane transporter activity
  7. Target

    Gamma-glutamyl hydrolase

    go.drugbank.com/bio_entities/BE0000265
    EnzymeHumans

    Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate (PubMed:11005824, PubMed:8816764).

  8. Target

    Thymidylate synthase

    go.drugbank.com/bio_entities/BE0000324
    TargetEnzymeHumans

    Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes t...

    Function: folic acid binding
  9. Target

    Formimidoyltransferase-cyclodeaminase

    go.drugbank.com/bio_entities/BE0000822
    TargetHumans

    Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool

    Function: folic acid binding
  10. Target

    ATP-binding cassette sub-family C member 5

    go.drugbank.com/bio_entities/BE0003639
    TransporterTargetHumans

    Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro) (PubMed:10893247, PubMed:12637526, PubMed:12695538, PubMed:15899835, PubMed