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Displaying results 1 - 10 of 13 in total
  1. Target

    Solute carrier family 12 member 6

    go.drugbank.com/bio_entities/BE0000140
    TargetTransporterHumans

    Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10600773, PubMed:11551954, PubMed:16048901, PubMed:18566107, PubMed:19665974, PubMed:21628467, PubMed:27485015

    Synonyms: Electroneutral potassium-chloride cotransporter 3Function: potassium
  2. Target

    Solute carrier family 12 member 7

    go.drugbank.com/bio_entities/BE0000276
    TargetTransporterHumans

    Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127).

    Synonyms: Electroneutral potassium-chloride cotransporter 4Function: potassium
  3. Target

    Solute carrier family 12 member 4

    go.drugbank.com/bio_entities/BE0000601
    TargetTransporterHumans

    Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912).

    Synonyms: Electroneutral potassium-chloride cotransporter 1
  4. Target

    Solute carrier family 12 member 5

    go.drugbank.com/bio_entities/BE0000047
    TargetTransporterHumans

    Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (PubMed:12106695). … As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization

    Synonyms: Electroneutral potassium-chloride cotransporter 2
  5. Target

    Solute carrier family 12 member 5

    go.drugbank.com/bio_entities/BE0009674
    TransporterMouse

    Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (By similarity). … As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization

    Synonyms: Electroneutral potassium-chloride cotransporter 2
  6. Target

    Solute carrier family 12 member 2

    go.drugbank.com/bio_entities/BE0000281
    TargetTransporterHumans

    Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714

    Synonyms: Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
  7. Target

    Solute carrier family 12 member 1

    go.drugbank.com/bio_entities/BE0000502
    TargetTransporterHumans

    Renal sodium, potassium and chloride non-electrogenic ion symporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration

    Synonyms: Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
  8. Target

    Chloride channel protein 2

    go.drugbank.com/bio_entities/BE0000765
    TargetHumans

    potassium concentrations (PubMed:19191339, PubMed:22405205, PubMed:23707145). … Contributes to chloride conductance involved in neuron excitability.

    Polypeptides: Chloride channel protein 2Function: chloride channel regulator activity
  9. Target

    Voltage-gated Potassium Channels

    go.drugbank.com/bio_entities/BE0009847
    Target

    When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604). … Association with KCNQ1/KCLQT1 alpha subunit may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a

    Polypeptides: A-type voltage-gated potassium channel KCND1, A-type voltage-gated potassium channel KCND2Synonyms: Shal-type potassium channel KCND1, Minimal potassium channel
  10. Target

    Potassium channel subfamily T member 2

    go.drugbank.com/bio_entities/BE0015626
    TargetHumans

    Sodium-activated and chloride-activated potassium channel (PubMed:14684870, PubMed:16687497, PubMed:25214519, PubMed:27682982, PubMed:29069600, PubMed:29740868).

    Polypeptides: Potassium channel subfamily T member 2Synonyms: Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1, Sequence like an intermediate conductance potassium channel subunit