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Transforming growth factor beta-1 proprotein
go.drugbank.com/bio_entities/BE0000984TargetHumansTransforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit … of TGF-beta-1, respectively
Polypeptides: Transforming growth factor beta-1 proproteinTransforming growth factor beta activator LRRC32
go.drugbank.com/bio_entities/BE0014554TargetHumansKey regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19651619, PubMed … Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19651619, PubMed:19750484).
Polypeptides: Transforming growth factor beta activator LRRC32TGF-beta receptor type-1
go.drugbank.com/bio_entities/BE0003782TargetHumansThis constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. … Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3.
Polypeptides: TGF-beta receptor type-1Synonyms: Transforming growth factor-beta receptor type I, TGFR-1Integrin beta-8
go.drugbank.com/bio_entities/BE0012912TargetHumansIntegrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in … TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable).
Polypeptides: Integrin beta-8Integrin beta-6
go.drugbank.com/bio_entities/BE0010033TargetHumansIntegrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in … TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447)
Polypeptides: Integrin beta-6TGF-beta receptor type-2
go.drugbank.com/bio_entities/BE0001861TargetHumansThis constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways … Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3.
Polypeptides: TGF-beta receptor type-2Synonyms: Transforming growth factor-beta receptor type II, TGF-beta receptor type IISMAD family member 2
go.drugbank.com/bio_entities/BE0004445TargetHumansReceptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. … Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription.
Synonyms: JV18-1Integrin alpha-V
go.drugbank.com/bio_entities/BE0003576TargetHumansIntegrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP … ), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447).
SMAD family member 7
go.drugbank.com/bio_entities/BE0011560TargetHumansAntagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating … Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation.