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Displaying results 1 - 10 of 760 in total
  1. Target

    Mannosyl-oligosaccharide alpha-1,2-mannosidase

    go.drugbank.com/bio_entities/BE0001789
    TargetPenicillium citrinum

    Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).

    Synonyms: Man(9)-alpha-mannosidase
  2. Target

    Cation-dependent mannose-6-phosphate receptor

    go.drugbank.com/bio_entities/BE0004494
    TargetTransporterHumans

    Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal

    Polypeptides: Cation-dependent mannose-6-phosphate receptorSynonyms: CD Man-6-P receptor, 46 kDa mannose 6-phosphate receptor
  3. Target

    Alpha-mannosidase 2

    go.drugbank.com/bio_entities/BE0003505
    TargetHumans

    Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway

    Synonyms: Man II
  4. Target

    Proto-oncogene Mas

    go.drugbank.com/bio_entities/BE0012496
    TargetHumans

    Acts as functional receptor for CXCL17 and induces chemotactic movement (PubMed:41167449) … Receptor mainly stimulated by angiotensin 1-7, which is a bioactive metabolite of the angiotensin produced by ACE2 (PubMed:17984366).

    Polypeptides: Proto-oncogene MasSynonyms: MAS
  5. Target

    Cation-independent mannose-6-phosphate receptor

    go.drugbank.com/bio_entities/BE0003623
    TargetTransporterHumans

    The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). … Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal

    Polypeptides: Cation-independent mannose-6-phosphate receptorSynonyms: CI Man-6-P receptor, IGF-II receptor
  6. Target

    Hut operon positive regulatory protein

    go.drugbank.com/bio_entities/BE0001281
    TargetBacillus subtilis (strain 168)

    Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization

    Polypeptides: Hut operon positive regulatory protein
  7. Target

    Mas-related G protein-coupled receptor member X2

    go.drugbank.com/bio_entities/BE0018408
    TargetHumans

    Mast cell-specific G protein-coupled receptor for basic secretagogues, which regulates mast cell degranulation and itch-related hypersensitivity reactions (PubMed:22069323, PubMed:25517090, PubMed:28288109 … Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37

    Polypeptides: Mas-related G protein-coupled receptor member X2Function: C-C chemokine receptor activity
  8. Target

    MAP kinase-activated protein kinase 5

    go.drugbank.com/bio_entities/BE0009478
    TargetHumans

    Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-...

    Polypeptides: MAP kinase-activated protein kinase 5
  9. Target

    MAP kinase-activated protein kinase 3

    go.drugbank.com/bio_entities/BE0004064
    TargetHumans

    Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. … Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.

    Polypeptides: MAP kinase-activated protein kinase 3
  10. Target

    MAP/microtubule affinity-regulating kinase 3

    go.drugbank.com/bio_entities/BE0009481
    TargetHumans

    Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TA...

    Polypeptides: MAP/microtubule affinity-regulating kinase 3