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Melanoma antigen preferentially expressed in tumors
go.drugbank.com/bio_entities/BE0010493TargetHumansSubstrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:21822215, PubMed:26138980). The CRL2(PRAME) complex mediate...
Polypeptides: Melanoma antigen preferentially expressed in tumorsSynonyms: Preferentially expressed antigen of melanomaTriggering receptor expressed on myeloid cells 2
go.drugbank.com/bio_entities/BE0020451TargetHumansForms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor prot...
Polypeptides: Triggering receptor expressed on myeloid cells 2Synonyms: Triggering receptor expressed on monocytes 2Triggering receptor expressed on myeloid cells 1
go.drugbank.com/bio_entities/BE0001288TargetHumansCell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102). Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes an...
Polypeptides: Triggering receptor expressed on myeloid cells 1Synonyms: Triggering receptor expressed on monocytes 1T-lymphocyte activation antigen CD80
go.drugbank.com/bio_entities/BE0000847TargetHumansAlso acts as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses (PubMed:36727298). … Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:
Synonyms: CTLA-4 counter-receptor B7.1T-lymphocyte activation antigen CD86
go.drugbank.com/bio_entities/BE0000846TargetHumansActs as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:
Synonyms: CTLA-4 counter-receptor B7.2Transmembrane channel-like protein 1
go.drugbank.com/bio_entities/BE0017493TargetHumansPore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system (By similarity). The MET com...
Synonyms: Transmembrane cochlear-expressed protein 1Transmembrane channel-like protein 2
go.drugbank.com/bio_entities/BE0017488TargetHumansPore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system (PubMed:11850618). The MET c...
Synonyms: Transmembrane cochlear-expressed protein 2Ubiquitin-like protein NEDD8
go.drugbank.com/bio_entities/BE0014813TargetHumansUbiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53 (PubMed:10318914, PubMed:10597293, PubMed:11953428, Pu...
Synonyms: Neural precursor cell expressed developmentally down-regulated protein 8Hepcidin
go.drugbank.com/bio_entities/BE0009858EnzymeTargetHumansLiver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exp...
Synonyms: Liver-expressed antimicrobial peptide 1Cell growth-regulating nucleolar protein
go.drugbank.com/bio_entities/BE0008958TargetMousePlays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity). Also acts at the level of transcription regulation. Alon...
Synonyms: Protein expressed in male leptotene and zygotene spermatocytes 264