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Displaying results 1 - 10 of 16 in total
  1. Target

    cDNA FLJ60754, moderately similar to Survival motor neuron protein

    go.drugbank.com/bio_entities/BE0009143
    TargetHumans

    Polypeptides: cDNA FLJ60754, moderately similar to Survival motor neuron proteinSynonyms: cDNA FLJ60754, moderately similar to Survival motor neuron protein
  2. Target

    Protein RIC-3

    go.drugbank.com/bio_entities/BE0009005
    TargetHumans

    Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors (PubMed:12821669, PubMed:15504725, PubMed:16120769, PubMed:18691158, PubMed:...

    Synonyms: Resistant to inhibitor of cholinesterase 3
  3. Target

    Afadin

    go.drugbank.com/bio_entities/BE0004342
    TargetHumans

    Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). … Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs

    Synonyms: ALL1-fused gene from chromosome 6 protein
  4. Target

    Tryptophan 2,3-dioxygenase

    go.drugbank.com/bio_entities/BE0003532
    EnzymeTargetHumans

    Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.

    Synonyms: TO
  5. Target

    Interleukin-33

    go.drugbank.com/bio_entities/BE0010097
    TargetHumans

    Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016, PubMed:19841166).

    Synonyms: Nuclear factor from high endothelial venules
  6. Target

    Serine/threonine-protein kinase/endoribonuclease IRE1

    go.drugbank.com/bio_entities/BE0003839
    TargetHumans

    The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:21317875, PubMed:24508390). … In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875).

    Synonyms: Endoplasmic reticulum-to-nucleus signaling 1
  7. Target

    Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

    go.drugbank.com/bio_entities/BE0004448
    TargetHumans

    Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371) … GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:27863242).

    Synonyms: G1 to S phase transition protein 1 homolog
  8. Target

    Mitogen-activated protein kinase kinase kinase kinase 5

    go.drugbank.com/bio_entities/BE0009474
    TargetHumans

    May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway

    Synonyms: Kinase homologous to SPS1/STE20
  9. Target

    Serine/threonine-protein kinase TAO2

    go.drugbank.com/bio_entities/BE0004632
    TargetHumans

    Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. … This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation

    Synonyms: Kinase from chicken homolog C
  10. Target

    Serine/threonine-protein kinase TAO1

    go.drugbank.com/bio_entities/BE0009392
    TargetHumans

    Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules … Involved in G protein-coupled receptor signaling to p38/MAPK14.

    Synonyms: Kinase from chicken homolog B