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Displaying results 1 - 10 of 75 in total
  1. Target

    GTPase Der

    go.drugbank.com/bio_entities/BE0001848
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity). Has GTPase activity but no ATPase activity. GTP, GDP, and dGTP but not GMP, ATP, CTP, and UTP compete for GTP binding.

    Polypeptides: GTPase Der
  2. Target

    Mannosyl-oligosaccharide alpha-1,2-mannosidase

    go.drugbank.com/bio_entities/BE0001789
    TargetPenicillium citrinum

    Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).

    Synonyms: Man(9)-alpha-mannosidase
  3. Target

    Aminoglycoside nucleotidyltransferase (4')

    go.drugbank.com/bio_entities/BE0003547
    EnzymeStaphylococcus aureus

    Inactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside.

    Synonyms: kan
  4. Target

    Cation-dependent mannose-6-phosphate receptor

    go.drugbank.com/bio_entities/BE0004494
    TargetTransporterHumans

    Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the ...

    Synonyms: CD Man-6-P receptor
  5. Target

    Alpha-mannosidase 2

    go.drugbank.com/bio_entities/BE0003505
    TargetHumans

    Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway

    Synonyms: Man II
  6. Target

    Proto-oncogene Mas

    go.drugbank.com/bio_entities/BE0012496
    TargetHumans

    G protein-coupled receptor that plays key roles in the renin-angiotensin system (RAS) specifically in the protective, counter-regulatory arm of the RAS (PubMed:25967876). Receptor mainly stimulated by angiotensin 1-7, which is a bioactiv...

    Polypeptides: Proto-oncogene MasSynonyms: MAS
  7. Target

    Cation-independent mannose-6-phosphate receptor

    go.drugbank.com/bio_entities/BE0003623
    TargetTransporterHumans

    Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phos...

    Synonyms: CI Man-6-P receptor
  8. Target

    MAP kinase-activated protein kinase 5

    go.drugbank.com/bio_entities/BE0009478
    TargetHumans

    Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-...

    Polypeptides: MAP kinase-activated protein kinase 5
  9. Target

    MAP kinase-activated protein kinase 3

    go.drugbank.com/bio_entities/BE0004064
    TargetHumans

    Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates.

    Polypeptides: MAP kinase-activated protein kinase 3
  10. Target

    MAP/microtubule affinity-regulating kinase 3

    go.drugbank.com/bio_entities/BE0009481
    TargetHumans

    Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TA...

    Polypeptides: MAP/microtubule affinity-regulating kinase 3