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Displaying results 1 - 10 of 737 in total
  1. Target

    Lethal factor

    go.drugbank.com/bio_entities/BE0001363
    TargetBacillus anthracis

    LF is not toxic by itself and only acts as a lethal factor when associated with protective antigen (PA) to form the lethal toxin (LeTx): PA is required for LF translocation into the host cytosol (PubMed … Lethal factor (LF), which constitutes one of the three proteins composing the anthrax toxin, is able to trigger rapid cell death in macrophages (PubMed:10475971, PubMed:11104681, PubMed:3711080, PubMed

    Polypeptides: Lethal factorSynonyms: Anthrax lethal toxin endopeptidase component
  2. Target

    Pregnancy zone protein

    go.drugbank.com/bio_entities/BE0009089
    TargetHumans

    Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves...

    Polypeptides: Pregnancy zone protein
  3. Target

    Lethal(3)malignant brain tumor-like protein 1

    go.drugbank.com/bio_entities/BE0003191
    TargetHumans

    Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcript...

    Polypeptides: Lethal(3)malignant brain tumor-like protein 1
  4. Target

    Leucine-rich repeat-containing G protein-coupled receptor 5

    go.drugbank.com/bio_entities/BE0010835
    TargetHumans

    Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle.

    Polypeptides: Leucine-rich repeat-containing G protein-coupled receptor 5Synonyms: G protein-coupled receptor 49, G protein-coupled receptor 67
  5. Target

    Insulin receptor

    go.drugbank.com/bio_entities/BE0000033
    TargetHumans

    When present in a hybrid receptor with IGF1R, binds IGF1. … Receptor tyrosine kinase which mediates the pleiotropic actions of insulin.

    Polypeptides: Insulin receptor
  6. Target

    Estrogen receptor

    go.drugbank.com/bio_entities/BE0000123
    TargetHumans

    Nuclear hormone receptor. … Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner.

    Polypeptides: Estrogen receptorSynonyms: Estradiol receptor, Nuclear receptor subfamily 3 group A member 1
  7. Target

    Secretin receptor

    go.drugbank.com/bio_entities/BE0000318
    TargetHumans

    G protein-coupled receptor activated by secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:25332973 … Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain

    Polypeptides: Secretin receptorFunction: G protein-coupled peptide receptor activity
  8. Target

    Prolactin receptor

    go.drugbank.com/bio_entities/BE0000345
    TargetHumans

    This is a receptor for the anterior pituitary hormone prolactin (PRL).

    Polypeptides: Prolactin receptor
  9. Target

    Thyrotropin receptor

    go.drugbank.com/bio_entities/BE0000490
    TargetHumans

    Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). … Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258).

    Polypeptides: Thyrotropin receptorSynonyms: Thyroid-stimulating hormone receptor
  10. Target

    Progesterone receptor

    go.drugbank.com/bio_entities/BE0000557
    TargetHumans

    Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor

    Polypeptides: Progesterone receptorSynonyms: Nuclear receptor subfamily 3 group C member 3