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Norepinephrine

go.drugbank.com/drugs/DB00368
ApprovedInvestigational

Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in pla...

  1. Target

    Sodium-dependent noradrenaline transporter

    go.drugbank.com/bio_entities/BE0000486
    TargetTransporterHumans

    Is responsible for norepinephrine re-uptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis (By similarity). … Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signaling neurotransmitter in the autonomic sympathetic nervous system (PubMed:2008212, PubMed

    Synonyms: Norepinephrine transporter
  2. Indication

    Necrosis caused by norepinephrine extravasation

    go.drugbank.com/conditions/DBCOND0022166
    Drugs: Phentolamine
    Synonyms: Necrosis caused by norepinephrine extravasation, Necrosis caused by Administration site extravasation with Norepinephrine
  3. Pathway

    Amine Oxidase Norepinephrine

    smpdb.ca/view/SMP0130460
    Physiological

    The first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. … The monoamine oxidase is an enzyme that catalyzes the oxidative deamination of many amines like serotonin, norepinephrine, epinephrine, and dopamine. There are 2 isoforms of this protein: A and B.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · NADH · Sapropterin +7 more
  4. Pathway

    Norepinephrine Neurological

    smpdb.ca/view/SMP0130946
    Physiological

    Norepinephrine is a catecholamine and a phenethylamine. … In mammals, norepinephrine is rapidly degraded to various metabolites.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +3 more
  5. Pathway

    Methylphenidate Norepinephrine Reuptake Inhibitor Action Pathway

    smpdb.ca/view/SMP0126572
    Drug action

    This abnormality makes it harder for dopamine and norepinephrine to bind to the receptors. … Norepinephrine is then transported to the prefrontal cortex and released into the synapse when the neuron is stimulated and fires.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · ATP · Norepinephrine · Methylphenidate +7 more
  6. Pathway

    Methamphetamine Norepinephrine Reuptake Inhibitor Action Pathway

    smpdb.ca/view/SMP0126618
    Drug action

    Methamphetamine also acts on norepinephrine pathways in similar ways. Norepinephrine is synthesized from dopamine and stored in presynaptic vesicles. … Methamphetamine has the same mechanisms of action for displacing norepinephrine into the cytosol and inhibiting the re-uptake of norepinephrine from the synapse.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +4 more
  7. Pathway

    Duloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway

    smpdb.ca/view/SMP0126450
    Drug action

    It blocks both sodium dependent serotonin and sodium dependent norepinephrine transporters from removing serotonin and norepinephrine respectively from the synaptic cleft. … In depressed individuals, serotonin and norepinephrine stimulation is low so an increase in serotonin and norepinephrine in the synapses can increase the stimulation of these receptors.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · ATP · Norepinephrine · Duloxetine +8 more
  8. Pathway

    Amitriptyline Norepinephrine Reuptake Inhibitor Action Pathway

    smpdb.ca/view/SMP0125187
    Drug action

    The norepinephrine in the synapse is rapidly taken up by the norepinephrine reuptake transporter on the presynaptic neuron, and is recycled. … Amitriptyline by blocking the reuptake of both serotonin and norepinephrine neurotransmitters. In adrenergic neurons, norepinephrine is synthesized from tyrosine and stored in synaptic vesicles.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Amitriptyline · Sapropterin · Norepinephrine +5 more
  9. Pathway

    Duloxetine (SNRI) - Norepinephrine Reuptake Inhibiton

    smpdb.ca/view/SMP0125000
    Drug action

    It blocks both sodium dependent serotonin and sodium dependent norepinephrine transporters from removing serotonin and norepinephrine respectively from the synaptic cleft. … In depressed individuals, serotonin and norepinephrine stimulation is low so an increase in serotonin and norepinephrine in the synapses can increase the stimulation of these receptors.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Duloxetine · Dopamine +4 more