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Displaying results 1 - 10 of 31 in total
  1. Drug

    Benidipine

    go.drugbank.com/drugs/DB09231
    Investigational

    Benidipine has the formula 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid methyl 1-(phenylmethyl)-3-piperidinyl ester hydrochloride. It is a synthetic dihydropyridine derivative that has anti-hypertensive and a...

  2. Target

    Tripeptidyl-peptidase 1

    go.drugbank.com/bio_entities/BE0011158
    TargetHumans

    Lysosomal serine protease with tripeptidyl-peptidase I activity (PubMed:11054422, PubMed:19038966, PubMed:19038967). … May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (PubMed:11054422, PubMed:19038966, PubMed:19038967).

    Polypeptides: Tripeptidyl-peptidase 1Synonyms: Tripeptidyl-peptidase I, Tripeptidyl aminopeptidase
  3. Drug

    Boceprevir

    go.drugbank.com/drugs/DB08873
    ApprovedWithdrawn

    Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is...

    Mixtures: Victrelis Triple, Victrelis Triple
  4. Target

    Prolyl tripeptidyl peptidase

    go.drugbank.com/bio_entities/BE0004097
    TargetPorphyromonas gingivalis (strain ATCC BAA-308 / W83)

    Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position.

    Polypeptides: Prolyl tripeptidyl peptidaseSynonyms: Prolyl tripeptidyl peptidase A, Prolyl tripeptidyl peptidase 81.8 kDa form
  5. Pathway

    Tripelennamine H1-Antihistamine Blood Vessel Constriction Action Pathway

    smpdb.ca/view/SMP0174989
    Drug action

    Tripelennamine is a first-generation ethanolamine H1-antihistamine. … Tripelennamine inhibits the H1 histamine receptor on blood vessel endothelial cells.

    Drugs: Arginine · Citrulline · Clemastine · Sapropterin · Nitric Oxide · Tripelennamine +5 more
  6. Pathway

    Tripelennamine H1-Antihistamine Action

    smpdb.ca/view/SMP0057587
    Drug action

    Tripelennamine is a first-generation ethylenediamine H1-antihistamine.

    Drugs: Tripelennamine · Calcium
  7. Pathway

    Tripelennamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0174897
    Drug action

    Tripelennamine is a first-generation ethanolamine H1-antihistamine. … Tripelennamine also inhibits the H1 histamine receptor on bronchiole smooth muscle myocytes.

    Drugs: Tripelennamine · Calcium · Magnesium cation
  8. Pathway

    Tripelennamine H1-Antihistamine Immune Response Action Pathway

    smpdb.ca/view/SMP0175081
    Drug action

    Tripelennamine is a first-generation ethanolamine H1-antihistamine.

    Drugs: Tripelennamine · Calcium
  9. Target

    Leukotriene A-4 hydrolase

    go.drugbank.com/bio_entities/BE0001680
    TargetHumans

    Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:18804029, PubMed:20813919). … In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro

    Synonyms: Tripeptide aminopeptidase LTA4H
  10. Target

    UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

    go.drugbank.com/bio_entities/BE0003765
    TargetStreptococcus pneumoniae (strain ATCC BAA-255 / R6)

    Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

    Polypeptides: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase