Displaying drugs 226 - 250 of 11681 in total
Trichloroethylene
Trichloroethylene is a halocarbon commonly used as an industrial solvent, not to be confused with the similar 1,1,1-trichloroethane, also known as chlorothene. It has been sold under a variety of trade names including Trimar and Trilene and used as a volatile anesthetic and as an inhaled obstetrical analgesic. Environmental exposure,...
Approved
Matched Description: … It has been sold under a variety of trade names including Trimar and Trilene and used as a volatile anesthetic ... Trichloroethylene is a halocarbon commonly used as an industrial solvent, not to be confused with the ... Environmental exposure, particularly groundwater and drinking water contamination from industrial discharge, is a …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
p-Phenylenediamine
Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …
Imipramine
Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, imipramine exerts...
Approved
Matched Description: … In depressed individuals, imipramine exerts a positive effect on mood. ... Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. ... They contain a tricyclic ring system with an alkyl amine substituent on the central ring. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C18 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C18 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index …
Propofol
Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness,...
Approved
Investigational
Vet approved
Matched Description: … administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a …
Isoniazid
Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Approved
Investigational
Matched Description: … Antibacterial agent used primarily as a tuberculostatic. …
Dimethyl sulfoxide
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dimethyl sulfoxide shows a range of pharmacological activity including...
Approved
Vet approved
Matched Description: … A highly polar organic liquid, that is used widely as a chemical solvent. ... Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application ... Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Cimetidine
A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Approved
Investigational
Matched Description: … Cimetidine has a range of pharmacological actions. ... A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. …
Methocarbamol
Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated pain.[A178441,A178450] It is a guaiacol glyceryl ether. Methocarbamol tablets and intramuscular injections are prescription medicines indicated in the United States as an adjunct to rest, physical therapy, and other measures for the relief of...
Approved
Vet approved
Matched Description: … [A178441,A178450] It is a guaiacol glyceryl ether. ... Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated ... [Label,L6268] In Canada, methocarbamol can be sold as an over the counter oral medicine at a lower dose …
Matched Mixtures name: … SINAXAR ® A TABLETAS ... SINAXAR ® A TABLETAS …
Matched Mixtures name: … SINAXAR ® A TABLETAS ... SINAXAR ® A TABLETAS …
Flurbiprofen
Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis....
Approved
Investigational
Matched Description: … Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic …
Matched Products: … STREPSILS INTENSIVE SOLUCION EN SPRAY SABOR A MIEL Y LIMON …
Matched Products: … STREPSILS INTENSIVE SOLUCION EN SPRAY SABOR A MIEL Y LIMON …
Rotavirus vaccine
Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotarix is a live attenuated vaccine containing the...
Approved
Matched Description: … Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. ... [L1116] Rotarix is a live attenuated vaccine containing the 89-12 human strain. …
Matched Salts name: … Human Rotavirus A type G1P(8) strain RIX4414 live antigen ... Human Rotavirus A type G1P7(5) strain WI79 live antigen ... Human Rotavirus A type G2P7(5) strain SC2 live antigen ... Human Rotavirus A type G4P7(5) strain BRB live antigen ... Human Rotavirus A type G3P7(5) strain WI78 live antigen …
Matched Salts name: … Human Rotavirus A type G1P(8) strain RIX4414 live antigen ... Human Rotavirus A type G1P7(5) strain WI79 live antigen ... Human Rotavirus A type G2P7(5) strain SC2 live antigen ... Human Rotavirus A type G4P7(5) strain BRB live antigen ... Human Rotavirus A type G3P7(5) strain WI78 live antigen …
Emicizumab
Emicizumab is a humanized recombinant monoclonal antibody that mimics the function of the coagulation Factor VIII and it has the capacity to bind simultaneously to activated Factor IX and Factor X. The ability of Emicizumab to bind to all these three different factors allows it to overcome immunogenicity and unstable...
Approved
Investigational
Matched Description: … Emicizumab is a humanized recombinant monoclonal antibody that mimics the function of the coagulation ... Ltd. and co-developed with Roche and Genentech.[L1015] ... [A31279, L1016] It was created by Chugai Pharmaceuticals Co. …
Procarbazine
An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
Approved
Investigational
Antithrombin III human
A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Approved
Matched Description: … It is a member of the serpin superfamily. ... A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and …
Copanlisib
Copanlisib is a selective pan-Class I phosphoinositide 3-kinase (PI3K) inhibitor with preferential activity against the alpha and delta isoforms. PI3K, a lipid kinase that activates downstream signalling pathways involved in cell survival and growth, that exists in different isoforms and is often overexpressed in hematological malignancies. Copanlisib was granted accelerated...
Approved
Investigational
Matched Description: … Copanlisib is a selective pan-Class I phosphoinositide 3-kinase (PI3K) inhibitor with preferential activity ... PI3K, a lipid kinase that activates downstream signalling pathways involved in cell survival and growth …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index …
Lopinavir
Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. Lopinavir is marketed and administered exclusively in combination with ritonavir - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to lopinavir's poor oral bioavailability...
Approved
Matched Description: … Ritonavir is a potent inhibitor of the enzymes responsible for lopinavir metabolism, and its co-administration ... [saquinavir], [nelfinavir]), lopinavir is a peptidomimetic molecule - it contains a hydroxyethylene scaffold …
Magnesium trisilicate
Magnesium trisilicate is an inorganic compound that is used as an antacid in the treatment of peptic ulcers.
Approved
Matched Mixtures name: … Mag-A-folic Tab …
Hydrocortisone
Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone was granted FDA approval on 5 August 1952.
Approved
Vet approved
Matched Iupac: … 1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. …
Matched Mixtures name: … Cho-A Care Lot 1% …
Matched Products: … SKIN A COOL Hydrocortisone Anti-Itch …
Matched Description: … Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. …
Matched Mixtures name: … Cho-A Care Lot 1% …
Matched Products: … SKIN A COOL Hydrocortisone Anti-Itch …
Larotrectinib
Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and...
Approved
Investigational
Matched Iupac: … (3S)-N-{5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}-3-hydroxypyrrolidine …
Matched Description: … Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine ... kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important …
Matched Description: … Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine ... kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important …
Durvalumab
Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote normal immune responses that attack tumour...
Approved
Investigational
Matched Description: … Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint ... recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture,[L12621] durvalumab is a …
Acetic acid
Acetic acid is a product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed) Acetic acid otic (for the ear) is an antibiotic that treats infections caused by bacteria or...
Approved
Matched Description: … It is used locally, occasionally internally, as a counterirritant and also as a reagent. ... Acetic acid is a product of the oxidation of ethanol and of the destructive distillation of wood. …
Matched Mixtures name: … POLYLAB T-EUSOL (SOLUTION A & B) ... POLYLAB T-EUSOL( SOLUTION A & B) ... SC Pharma Eusol Solution Max A & B …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Mixtures name: … POLYLAB T-EUSOL (SOLUTION A & B) ... POLYLAB T-EUSOL( SOLUTION A & B) ... SC Pharma Eusol Solution Max A & B …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Darunavir
Darunavir is a protease inhibitor used with other HIV protease inhibitor drugs as well as ritonavir for the effective management of HIV-1 infection. As a second-generation protease inhibitor, darunavir is designed to combat resistance to standard HIV therapy.[A2278,A2281] It was initially approved by the FDA in 2006. Darunavir is being...
Approved
Matched Description: … Darunavir is a protease inhibitor used with other HIV protease inhibitor drugs as well as [ritonavir] ... [L9227] As a second-generation protease inhibitor, darunavir is designed to combat resistance to standard ... [L9227]
Darunavir is being studied as a possible treatment for SARS-CoV-2, the coronavirus responsible …
Idelalisib
Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with rituximab in patients for whom rituximab...
Approved
Matched Description: … rituximab in patients for whom rituximab alone would be considered appropriate therapy due to other co-morbidities ... Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic ... For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index …
Troglitazone
Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by pioglitazone and rosiglitazone.
Approved
Investigational
Withdrawn
Deferoxamine
Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
Approved
Investigational
Matched Description: … It forms iron complexes and is used as a chelating agent, particularly in the mesylate form. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Methimazole
Methimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones.[A184559,A184733,A184694] It was first introduced as an antithyroid agent in 1949 and is now commonly used in the management of hyperthyroidism, particularly in those for whom more aggressive options such as surgery or radioactive iodine therapy are inappropriate.[L8336,L8339]...
Approved
Matched Description: … Methimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones. ... [L8336,L8339]
On a weight basis, methimazole is 10 times more potent than the other major antithyroid ... hepatotoxicity carried by the latter,[A184757] with propylthiouracil being preferred in pregnancy due to a …
Displaying drugs 226 - 250 of 11681 in total