Displaying drugs 10876 - 10900 of 12071 in total
CNS-5161
CNS 5161 is a blocker of the NMDA ion channel and has completed Phase IIa proof of concept clinical trials as a novel compound for the treatment of neuropathic pain.
Investigational
Matched Description: … as a novel compound for the treatment of neuropathic pain. ... CNS 5161 is a blocker of the NMDA ion channel and has completed Phase IIa proof of concept clinical trials …
PX-478
PX-478 is a small molecule inhibitor of hypoxia inducible factor (HIF)-1 alpha currently in a clinical trial in patients with advanced metastatic cancer and lymphoma. PX-478 was effective in models of both non-small cell lung cancer
and small cell lung cancer that express HIF-1 alpha.
Investigational
Matched Description: … PX-478 is a small molecule inhibitor of hypoxia inducible factor (HIF)-1 alpha currently in a clinical …
Refametinib
Investigational
Pascolizumab
Pascolizumab (SB 240683) is a humanized anti-interleukin-4 antibody with therapeutic potential in asthma.
Investigational
Matched Description: … Pascolizumab (SB 240683) is a humanized anti-interleukin-4 antibody with therapeutic potential in asthma …
Reversin 121
Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance.
Experimental
Matched Description: … Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug …
Petesicatib
Petesicatib is under investigation in clinical trial NCT02295332 (A Study of RG7625 in Healthy Volunteers).
Investigational
Matched Description: … Petesicatib is under investigation in clinical trial NCT02295332 (A Study of RG7625 in Healthy Volunteers …
KW-6356
KW-6356 is a selective antagonist of adenosine A2A receptors developed by Kyowa Kirin.
Experimental
Matched Description: … KW-6356 is a selective antagonist of adenosine A2A receptors developed by Kyowa Kirin.[L43822] …
TNB-383B
TNB-383B is a CD3 and B-cell maturation antigen T-cell engaging bispecific antibody.
Investigational
Matched Description: … TNB-383B is a CD3 and B-cell maturation antigen T-cell engaging bispecific antibody. …
RP-L301
RP-L301 is a lentiviral vector containing the human liver and erythroid pyruvate kinase gene.
Investigational
Matched Description: … RP-L301 is a lentiviral vector containing the human liver and erythroid pyruvate kinase gene. …
KT-253
KT-253 is a selective heterobifunctional small molecule degrader of mouse double minute 2 (MDM2).
Investigational
Matched Description: … KT-253 is a selective heterobifunctional small molecule degrader of mouse double minute 2 (MDM2). …
STP-707
STP-707 is a small interfering RNA (siRNA) targeting TGF-Beta1 and COX-2 mRNA.
Investigational
Matched Description: … STP-707 is a small interfering RNA (siRNA) targeting TGF-Beta1 and COX-2 mRNA. …
VB10.16
VB10.16 is a novel therapeutic antigen-presenting cell-targeting DNA vaccine developed to treat HPV16-positive cancers. It is composed of three parts, one encodes the E6/E7 fusion protein of human papillomavirus (HPV) type 16 (HPV16), a dimerization entity, and the part encoding a protein that specifically binds to antigen-presenting cells (APCs).
Investigational
Matched Description: … VB10.16 is a novel therapeutic antigen-presenting cell-targeting DNA vaccine developed to treat HPV16 ... of three parts, one encodes the E6/E7 fusion protein of human papillomavirus (HPV) type 16 (HPV16), a ... dimerization entity, and the part encoding a protein that specifically binds to antigen-presenting cells …
GS030-DP
GS030-DP is an optogenetic gene therapy being investigated for the treatment of retinitis pigmentosa. It targets retinal ganglion cells that encodes a light-sensitive channelrhodopsin, ChrimsonR-tdTomato (ChR-tdT), delivered by an AAV2.7m8 vector. It is a component of GS030, an investigational optogenetic treatment, in combination with a medical device GS030-MD.[A259816, L46701]
Investigational
Matched Description: … It is a component of GS030, an investigational optogenetic treatment, in combination with a medical device ... It targets retinal ganglion cells that encodes a light-sensitive channelrhodopsin, ChrimsonR-tdTomato …
NS-2359
NS2359 is a triple monoamine re-uptake inhibitor with a new, unique drug profile expected to yield important benefits compared to existing treatments of depression. Enhancing the function of the three neurotransmitters serotonin, noradrenalin and dopamine, NS2359 has a desired "triple-mode-of-action". This mode of action is expected to produce an optimal...
Investigational
Matched Description: … NS2359 is a triple monoamine re-uptake inhibitor with a new, unique drug profile expected to yield important ... Enhancing the function of the three neurotransmitters serotonin, noradrenalin and dopamine, NS2359 has a …
SVV-001
SVV-001 is investigated for use/treatment in cancer/tumors and lung cancer. SVV-001 is a solid. SVV-001 (Seneca Valley Virus) is a novel native picornavirus being developed as a systemically deliverable oncolytic virus for treatment of human cancers with neuroendocrine features. SVV-001 has also demonstrated cancer-killing specificity 10,000 times higher than that...
Investigational
Matched Description: … SVV-001 is a solid. ... SVV-001 (Seneca Valley Virus) is a novel native picornavirus being developed as a systemically deliverable …
GS-441524
GS-441524 is an adenosine nucleotide analog antiviral, similar to remdesivir.[A203057,L13239] This molecule was patented in 2009. In vitro studies of GS-441524 have determined it has a higher EC50 than remdesivir against a number of viruses, meaning GS-441524 is less potent.[A203057,A203057] GS-441524 continues to be studied in the treatment of Feline...
Experimental
Matched Description: … against a number of viruses, meaning GS-441524 is less potent. ... [L13775] _In vitro_ studies of GS-441524 have determined it has a higher EC50 than remdesivir ... A203057] GS-441524 continues to be studied in the treatment of Feline Infectious Peritonitis Virus, a …
Bamet-UD2
Bamet-UD2 is a novel bile acid-platinum derivative.
Experimental
Matched Description: … Bamet-UD2 is a novel bile acid-platinum derivative. …
Pidotimod
Pidotimod is a synthetic dipeptide with immunomodulatory properties.
Experimental
Matched Description: … Pidotimod is a synthetic dipeptide with immunomodulatory properties.[A7956] …
SB-218078
SB-218078 is a specific inhibitor of CHK1.
Investigational
Matched Description: … SB-218078 is a specific inhibitor of CHK1.[A253117] …
IMAB027
IMAB027 is a chimeric monoclonal antibody against Claudin 6.
Investigational
Matched Description: … IMAB027 is a chimeric monoclonal antibody against Claudin 6. …
BSK02
BSK02 is a Sperm Protein-17 oral microparticle vaccine
Investigational
Matched Description: … BSK02 is a Sperm Protein-17 oral microparticle vaccine …
BBT-059
BBT-059 is a long-acting interleukin-11 analog.
Investigational
Matched Description: … BBT-059 is a long-acting interleukin-11 analog. …
CPO-107
CPO-107 is a CD20-CD47 bispecific fusion protein
Investigational
Matched Description: … CPO-107 is a CD20-CD47 bispecific fusion protein …
Fobrepodacin
Investigational
Displaying drugs 10876 - 10900 of 12071 in total