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Displaying drugs 1151 - 1175 of 1588 in total

Interferon gamma-1b

Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence displayed is a cDNA sequence which...
Approved
Investigational
Matched Synonyms: … Interferon gamma-1b, recombinant …
Matched Description: … a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein …

Voretigene neparvovec

Voretigene Neparvovec-rzyl (VN-rzyl) is an adeno-associated virus vector-based gene therapy. An adeno-associated virus is a small virus that infects humans and other primates. It is not pathogenic and it causes a very mild immune response. This type of virus is vastly used as vectors for gene therapy because they can...
Approved
Matched Synonyms: … Recombinant adeno-associated virus retinal pigment epithelium gene vector AAV2-hRPE65v2 …

Coal tar

Coal tar is a brown or black liquid of extremely high viscosity. Coal tar is among the by-products when coal is carbonized to make coke or gasified to make coal gas. Coal tars are complex and variable mixtures of phenols, polycyclic aromatic hydrocarbons (PAHs), and heterocyclic compounds. It has been...
Approved
Matched Mixtures name: … Neutrogena T/Gel Therapeutic ... Denorex Therapeutic ... Denorex Therapeutic …
Matched Products: … Herbal Castle Deep Cleansing Protein Tar Shampoo ... Therapeutic ... Therapeutic T Plus …

Talquetamab

Talquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed CD3 T-cell engager. It consists of two arms - anti-GPRC5D and anti-CD3 arms - linked by two interchain disulfide bonds, each arm comprising a heavy and light chain. Talquetamab binds to GPRC5D, a cell surface...
Approved
Investigational
Matched Synonyms: … IMMUNOGLOBULIN G4-KAPPA/G4-LAMBDA, ANTI-(HOMO SAPIENS GPRC5D (G PROTEIN-COUPLED RECEPTOR CLASS C GROUP ... IMMUNOGLOBULIN G4-KAPPA/G4-LAMBDA, ANTI-(HOMO SAPIENS GPRC5D (G PROTEIN-COUPLED RECEPTOR CLASS C GROUP …
Matched Description: … Talquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed …

Lonoctocog alfa

Approved
Investigational
Matched Products: … AFSTYLA Antihemophilic Factor (Recombinant), Single Chain …

Scopolamine

Scopolamine is a tropane alkaloid isolated from members of the Solanaceae family of plants, similar to atropine and hyoscyamine, all of which structurally mimic the natural neurotransmitter acetylcholine.[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient than extracting scopolamine from plants. As an acetylcholine...
Approved
Investigational
Matched Description: … A228758] As a result of its anticholinergic effects, scopolamine is being investigated for diverse therapeutic ... acetylcholine receptors (mAChRs) in the central nervous system and throughout the body, inducing several therapeutic …
Matched Products: … SCOPODERM TTS 1.5 TRANSDERMAL THERAPEUTIC SYSTEM …

Albumin human

Human serum albumin is the primary protein present in human blood plasma. The main function of albumin is to maintain the oncotic pressure of blood . It binds to water, cations (such as Ca2+, Na+ and K+), fatty acids, hormones, bilirubin, thyroxine (T4) and pharmaceuticals (including barbiturates). Albumin represents approximately...
Approved
Matched Description: … Human serum albumin is the primary protein present in human blood plasma. ... Albumin represents approximately 50% of the total protein content in healthy humans [A40060]. ... Human albumin is a small globular protein (molecular weight: 66.5 kDa), consisting of a single chain …
Matched Mixtures name: … Venomil Wasp Venom Protein (12mcg) ... Venomil Yellow Hornet Venom Protein (12mcg) ... Venomil Yellow Jacket Venom Protein (12mcg) …
Matched Categories: … Blood Substitutes and Plasma Protein Fractions …
Matched Products: … Plasma Protein Lösung 50 g/l Infusionslösung …

Botulinum toxin type A

In 2002, botulinum toxin A, also known as onabotulinumtoxinA or Botox, was the first type A botulism toxin to be introduced into the market for cosmetic use. With a wide variety of applications and favourable safety profile, Botulinum toxin A injection is a minimally invasive and promising treatment for cosmetic...
Approved
Investigational
Matched Categories: … Other Miscellaneous Therapeutic Agents …
Matched Products: … Dysport Therapeutic …

Iodide I-131

Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of...
Approved
Investigational
Matched Description: … Therapeutic solutions of Sodium Iodide-131 are indicated for the treatment of hyperthyroidism and thyroid ... Because the thyroid gland naturally takes up iodine from the body, therapeutic methods using radioisotopes …
Matched Categories: … Radioactive Therapeutic Agent ... Therapeutic Radiopharmaceuticals …
Matched Products: … Sodium Iodide I 131 Therapeutic ... Sodium Iodide I-131 Therapeutic …

Mosunetuzumab

Mosunetuzumab is a humanized anti-CD20/CD3 bispecific antibody. It can recognize and bind two different targets simultaneously, CD20 on cancer B-cells and CD3 on T-cells, allowing it to redirect T-cell cytotoxic activity to cancer cells. The standard of care for patients with B-cell lymphoma includes an anti-CD20 monoclonal antibody, such as...
Approved
Investigational

Turoctocog alfa

Turoctocog alfa is a recombinant factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the N-terminus and 11 amino acids from the C-terminus of the naturally occurring B-domain. Turoctocog alfa is produced in Chinese hamster ovary (CHO) cells without addition of any...
Approved
Investigational
Matched Description: … Turoctocog alfa is a recombinant factor VIII (rFVIII) with a truncated B-domain made from the sequence …
Matched Categories: … Protein Precursors ... Recombinant Proteins …

Rurioctocog alfa pegol

Rurioctocog alfa pegol is a pegylated recombinant human coagulation factor VIII or antihemophilic factor. Factor VIII is an essential protein involved in normal blood clotting; thus, a deficient level of functional factor VIII is associated with an elevated risk for excessive bleeding caused by spontaneous or secondary events like trauma...
Approved
Experimental
Matched Description: … Factor VIII is an essential protein involved in normal blood clotting; thus, a deficient level of functional ... Rurioctocog alfa pegol is a pegylated recombinant human coagulation factor VIII or antihemophilic factor ... factor VIII produced by recombinant DNA technology from a Chinese hamster ovary cell line. …
Matched Categories: … Protein Precursors ... Recombinant Proteins …

Salicylic acid

A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics.
Approved
Investigational
Vet approved
Matched Mixtures name: … Neutrogena T/Gel Therapeutic ... System Acne Therapeutic System ... System Acne Therapeutic System …
Matched Products: … Therapeutic Dandruff ... Therapeutic Hydrogel ... Glovers Therapeutic Care …

Thrombomodulin Alfa

Thrombomodulin Alfa is a novel, recombinant and soluble thrombomodulin (ART-123). It is a human protein with both thrombin inhibiting and protein C stimulating activities, for the potential treatment of thromboembolism and blood clotting disorders, such as disseminated intravascular thromboembolism.
Approved
Investigational
Matched Description: … Thrombomodulin Alfa is a novel, recombinant and soluble thrombomodulin (ART-123). ... It is a human protein with both thrombin inhibiting and protein C stimulating activities, for the potential …

Casirivimab

Casirivimab is a monoclonal antibody combined with Imdevimab in Regeneron's antibody cocktail known as REGN-COV2 for the treatment of COVID-19. This drug is a combination of antibodies derived from humanized VelocImmune® mice in addition to blood samples from patients who have recovered from COVID-19. These antibodies have been formulated to...
Approved
Experimental
Matched Description: … Casirivimab and imdevimab are investigational recombinant human IgG1 monoclonal antibodies that, at this ... A224429] These antibodies have been formulated to bind to multiple locations on the SARS-COV-2 spike protein …

Bamlanivimab

Bamlanivimab (LY-CoV555, also known as LY3819253), is a synthetic monoclonal antibody (mAb) derived from one of the first blood samples in the United States from a patient who recovered from COVID-19.[A224039, L15311, L15316] Bamlanivimab is a neutralizing IgG1κ mAb directed against the SARS-CoV-2 spike (S) protein, which is described to...
Approved
Investigational
Matched Description: … L15311, L15316] Bamlanivimab is a neutralizing IgG1κ mAb directed against the SARS-CoV-2 spike (S) protein …

Pegloticase

Pegloticase is a porcine recombinant PEGylated uricase indicated for the treatment of chronic gout in adult patients that do not respond to other types of therapies. Pegloticase has a similar activity to rasburicase, an enzyme that metabolizes uric acid to allantoin. In gout patients treated with pegloticase, the conversion of...
Approved
Investigational
Matched Description: … Pegloticase is a porcine recombinant PEGylated uricase indicated for the treatment of chronic gout in ... Therefore therapeutic drug levels can be maintained with infrequent and relatively low pegloticase doses …
Matched Categories: … Recombinant Proteins …

Benzoyl peroxide

Benzoyl peroxide is a commonly used drug in topical treatments for acne.[L33249,L33264,L33269,L33299,L33314] It has been formulated as products with either a single active ingredient,[L33249,L33299] or with erythromycin, clindamycin, or adapalene. After administration, the peroxide bond is cleaved, allowing benzoyloxy radicals to nonspecifically interact with proteins.[A18903,A233859] This treatment decreases keratin and...
Approved
Matched Mixtures name: … System Acne Therapeutic System ... System Acne Therapeutic System ... Clenziderm Normal To Oily Skin Acne Therapeutic System …
Matched Products: … Clenziderm Therapeutic ... Clenziderm Acne Therapeutic System …

Human C1-esterase inhibitor

C1 Esterase Inhibitor (Human) is composed of purified endogenous complement component-1 esterase inhibitor (hC1INH) isolated from human plasma. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways.[L16586, L16606] This drug is indicated for prophylaxis and treatment of Hereditary Angioedema (HAE), a...
Approved

Netilmicin

Netilmicin is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. Netilmicin inhibits protein synthesis in susceptible organisms by binding to the bacterial 30S ribosomal subunit and interfering with mRNA binding and the acceptor tRNA site. The bactericidal effect...
Approved
Investigational
Matched Description: … Netilmicin inhibits protein synthesis in susceptible organisms by binding to the bacterial 30S ribosomal …
Matched Categories: … Protein Synthesis Inhibitors ... Narrow Therapeutic Index Drugs ... Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index …

Olipudase alfa

Olipudase alfa is recombinant human acid sphingomyelinase. It is the first and only enzyme replacement therapy in the world for the treatment of Acid Sphingomyelinase Deficiency (ASMD), also known as Niemann–Pick disease. ASMD is a rare lysosomal storage disease caused by mutations in the SMPD1 gene, leading to a deficiency...
Approved
Investigational
Matched Description: … Olipudase alfa is recombinant human acid sphingomyelinase. …
Matched Categories: … Recombinant Proteins …

Rivaroxaban

Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15...
Approved

Sirolimus

Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria Streptomyces hygroscopicus, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor...
Approved
Investigational
Matched Description: … kinase that regulates cell growth, proliferation, and survival. mTOR is an important therapeutic target ... is the inhibition of the mammalian target of rapamycin (mTOR), which is a serine/threonine-specific protein …
Matched Categories: … Protein Kinase Inhibitors ... Narrow Therapeutic Index Drugs ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …

Omacetaxine mepesuccinate

Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, omacetaxine mepesuccinate...
Approved
Investigational
Matched Description: … Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein …
Matched Categories: … Protein Synthesis Inhibitors ... Narrow Therapeutic Index Drugs …

Nuvaxovid

SARS-CoV-2, the causative agent of COVID-19, relies on the interaction between its trimeric spike (S) glycoprotein and angiotensin-converting enzyme 2 (hACE2) expressed on host cells in order to establish a productive infection in humans. Antibodies directed against the S protein are capable of blocking S-hACE2 interactions and neutralizing viral particles...
Approved
Investigational
Matched Description: … Nuvaxovid (NVX-CoV2373) contains a recombinant mutant S protein that is codon-optimized for baculovirus-mediated ... [A243789] Antibodies directed against the S protein are capable of blocking S-hACE2 interactions and ... [A243789, L39534] The resulting stable perfusion S protein nanoparticles are thermostable and capable …
Displaying drugs 1151 - 1175 of 1588 in total