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Displaying drugs 251 - 275 of 6877 in total

Trimethobenzamide

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric...
Approved
Investigational
Matched Description: … Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. …

Rosoxacin

Rosoxacin is a quinolone derivative antibiotic for the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Rosoxacin is known to be effective against penicillin resistant strains and is a single dose orally administered drug, which avoids all complications of parenteral administration seen with...
Approved
Investigational
Matched Description: … derivative antibiotic for the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and ... Rosoxacin is known to be effective against penicillin resistant strains and is a single dose orally administered …

Glymidine

Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin. The mechanism of action of glycodiazine in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta...
Approved
Investigational
Matched Description: … Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and ... appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and ... ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and …
Matched Categories: … Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Sulfamerazine

A sulfanilamide that is used as an antibacterial agent.
Approved
Vet approved
Matched Categories: … Sulfonamides and trimethoprim ... sulfamerazine and trimethoprim ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Benoxaprofen

The use of benoxaprofen, formerly marketed as Oraflex tablets, was associated with fatal cholestatic jaundice among other serious adverse reactions. The holder of the approved application voluntarily withdrew Oraflex tablets from the market on August 5, 1982.
Approved
Withdrawn
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Mepenzolate

Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ganglionic parasympathetic inhibitor. It has not been shown to be effective...
Approved
Matched Description: … It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. ... Mepenzolate diminishes gastric acid and pepsin secretion. …
Matched Categories: … Alimentary Tract and Metabolism …

Brivaracetam

Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam . It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 .
Approved
Investigational

Avibactam

Avibactam is a non-β-lactam β-lactamase inhibitor that is available in combination with ceftazidime (Avycaz). This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal infections in combination with metronidazole, and the treatment of complicated urinary tract infections, including pyelonephritis caused by antibiotic resistant-pathogens,...
Approved
Matched Description: … 2015 for the treatment of complicated intra-abdominal infections in combination with metronidazole, and ... As there is limited clinical safety and efficacy data, Avycaz should be reserved for patients over 18 …

Talazoparib

Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was approved by Health Canada...
Approved
Investigational
Matched Description: … (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and ... L47236] Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 [A260346] and ... [L47301] Talazoparib is currently used in the treatment of BRCA-mutated breast cancer and HRR-mutated …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Tilarginine

Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 Diabetes, Ocular Physiology, and Regional Blood Flow.
Approved
Investigational
Matched Description: … Diabetes, Ocular Physiology, and Regional Blood Flow. ... Tilarginine has been investigated for the basic science, treatment, and diagnostic of Obesity, Type 2 …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Selinexor

Selinexor is a first-in-class selective inhibitor of nuclear transport (SINE) compound. Selinexor, in combination with bortezomib and dexamethasone, is currently approved for the treatment of multiple myeloma, a type of cancer formed from antibody-producing plasma cells.[L7117,L7120,L10145] This condition is typically treated with high dose bortezomib and dexamethasone chemotherapy followed by...
Approved
Investigational
Matched Description: … and may include [melphalan] if the patient is not eligible for transplant. ... Selinexor, in combination with [bortezomib] and [dexamethasone], is currently approved for the treatment ... Other chemotherapies for multiple myeloma include [lenalidomide] and [dexamethasone], [thalidomide], …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Terizidone

Terizidone has been used in trials studying the treatment of Tuberculosis, HIV Infections, Multidrug Resistant Tuberculosis, and Extensively-drug Resistant Tuberculosis.
Approved
Investigational
Matched Description: … in trials studying the treatment of Tuberculosis, HIV Infections, Multidrug Resistant Tuberculosis, and …

Cyclosporine

Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus Beauveria nivea. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products...
Approved
Investigational
Vet approved
Matched Description: … treat various inflammatory and autoimmune conditions. ... calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and ... [A174049] Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Phenytoin

Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as...
Approved
Vet approved
Matched Description: … Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one ... [A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market. ... has also been investigated for several other indications such as bipolar disorder, retina protection, and …
Matched Categories: … Phenytoin and Prodrugs ... Metabolic Side Effects of Drugs and Substances …

Mitomycin

Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of Streptomyces caespitosus.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of the DNA double helix. Few other antibiotics have been...
Approved
Matched Description: … , RNA and protein synthesis) by cross-linking the complementary strands of the DNA double helix. ... [L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations …
Matched Categories: … Indicators and Reagents ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances …

Entecavir

Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS). Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents...
Approved
Investigational
Matched Description: … Food and Drug Administration (FDA) in March 2005. ... Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the ... manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B (lamivudine and …
Matched Categories: … Nucleosides and Nucleotides ... Nucleoside and Nucleotide Reverse Transcriptase Inhibitors …

Paliperidone

Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin...
Approved
Matched Description: … Paliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic ... therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and ... extended-release tablet, a once-monthly intramuscular injection, an every-three-month intramuscular injection, and …

Aminoglutethimide

An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant properties. (From Martindale,...
Approved
Investigational
Matched Description: … Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Mazindol

Mazindol is a tricyclic anorexigenic agent that is unrelated to and less toxic than amphetamine, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter. Mazindol is only approved in the United States for the treatment of Duchenne...
Approved
Investigational
Matched Description: … Mazindol is a tricyclic anorexigenic agent that is unrelated to and less toxic than [amphetamine], but ... Mazindol is only approved in the United States for the treatment of Duchenne muscular dystrophy, and ... It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter …
Matched Categories: … Alimentary Tract and Metabolism ... Anorexigenic Agents & Respiratory and CNS Stimulants ... Anorexigenic Agents & Respiratory and Cerebral Stimulants, Miscellaneous …

Gadoteridol

Gadoteridol is a macrocyclic nonionic gadolinium that provides contrast enhancement of the brain, spine, and surrounding tissues, resulting in improved visualization (compared with unenhanced MRI) of lesions with abnormal vascularity or those thought to disrupt the normal blood-brain barrier.[A263076,A263081,L49871] It was 1 of the 3 macrocyclic gadolinium-based contrast agents (GBCAs)...
Approved
Investigational
Matched Description: … Gadoteridol is a macrocyclic nonionic gadolinium that provides contrast enhancement of the brain, spine, and …

Procaine

A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). Procaine has also been investigated as an oral entry inhibitor in...
Approved
Investigational
Vet approved
Matched Description: … A local anesthetic of the ester type that has a slow onset and a short duration of action. ... It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Clidinium

Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the treatment of peptic ulcer disease and also...
Approved
Matched Description: … to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. ... or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome. ... Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies …
Matched Mixtures name: … Chlordiazepoxide Hydrochloride and Clidinium Bromide ... Chlordiazepoxide HCl and Clidinium Bromide ... Chlordiazepoxide Hydrochloride and Clidinium Bromide …
Matched Categories: … Alimentary Tract and Metabolism ... clidinium and psycholeptics …

Mifepristone

Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome....
Approved
Investigational
Matched Description: … Mifepristone is a progestational and glucocorticoid hormone antagonist. ... Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing ... The two marketed forms of mifepristone are Mifeprex® (mifepristone 200mg) and Korlym™ (mifepristone 300mg …
Matched Categories: … Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Carbocisteine

Dyspnea and cough are common symptoms of chronic obstructive pulmonary disease (COPD) and other respiratory conditions characterized by increased mucus production. Individuals with COPD have a greater risk of pulmonary infection due to the growth and accumulation of viruses and bacteria in thick bronchial mucus. Carbocisteine is a mucolytic drug...
Approved
Investigational
Matched Description: … Dyspnea and cough are common symptoms of chronic obstructive pulmonary disease (COPD)[A231169] and other ... by physicians in France and Italy. ... viruses and bacteria in thick bronchial mucus. …
Matched Categories: … Cough and Cold Preparations ... Amino Acids, Peptides, and Proteins …

Hexaminolevulinate

Hexaminolevulinate is an optical imaging drug. In solution form it is instilled intravesically for use with photodynamic blue light cystoscopy as an adjunct to white light cystoscopy. On May 28, 2010, the U.S. Food and Drug Administration (FDA) granted approval for hexaminolevulinate hydrochloride (Cysview for Intravesical Solution, Photocure ASA), as...
Approved
Matched Description: … Food and Drug Administration (FDA) granted approval for hexaminolevulinate hydrochloride (Cysview for …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Displaying drugs 251 - 275 of 6877 in total