Displaying drugs 301 - 325 of 620 in total
Evorpacept
evorpacept is under investigation in clinical trial NCT04755244 (A Study of Evorpacept (ALX148) With Venetoclax and Azacitidine for Acute Myeloid Leukemia (ASPEN-05)).
Investigational
Matched Synonyms: … of human signal regulatory protein alpha (SIRPalpha) variant 1 (v1) genetically linked to a modified and …
Matched Description: … is under investigation in clinical trial NCT04755244 (A Study of Evorpacept (ALX148) With Venetoclax and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … is under investigation in clinical trial NCT04755244 (A Study of Evorpacept (ALX148) With Venetoclax and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Vanglusagene ensiparvovec
Investigational
Matched Synonyms: … recombinant adeno-associated viral (AAV) vector that contains a bio-engineered capsid (AAV-Spark100) and …
Zinc citrate
Zinc citrate is a zinc salt of citric acid. It is available as dietary supplements as a treatment of zinc deficiency and source of zinc, which is an essential trace element. Zinc citrate demonstrates effective absorption following oral administration .
Investigational
Matched Synonyms: … Citric acid, zinc salt …
Matched Name: … Zinc citrate …
Matched Description: … It is available as dietary supplements as a treatment of zinc deficiency and source of zinc, which is ... Zinc citrate is a zinc salt of citric acid. ... Zinc citrate demonstrates effective absorption following oral administration [A27280]. …
Matched Mixtures name: … Super 7 Vitamin and Mineral Supplement ... Multivitamins and Minerals for Young Men ... Multivitamins and Minerals for Young Women …
Matched Salts name: … Zinc citrate trihydrate …
Matched Categories: … Zinc Compounds …
Matched Products: … Zinc 50 mg ... Zinc Tab 15mg ... Zinc Citrate Tab 15mg …
Matched Name: … Zinc citrate …
Matched Description: … It is available as dietary supplements as a treatment of zinc deficiency and source of zinc, which is ... Zinc citrate is a zinc salt of citric acid. ... Zinc citrate demonstrates effective absorption following oral administration [A27280]. …
Matched Mixtures name: … Super 7 Vitamin and Mineral Supplement ... Multivitamins and Minerals for Young Men ... Multivitamins and Minerals for Young Women …
Matched Salts name: … Zinc citrate trihydrate …
Matched Categories: … Zinc Compounds …
Matched Products: … Zinc 50 mg ... Zinc Tab 15mg ... Zinc Citrate Tab 15mg …
Ferric oxide
Iron(III) oxide or ferric oxide is the inorganic compound with the formula Fe2O3. It is one of the three main oxides of iron, the other two being iron(II) oxide (FeO) the rarer form, and iron(II,III) oxide (Fe3O4) which naturally as magnetite.
Experimental
Matched Synonyms: … Iron oxide ... Eisen(III)-oxid ... Iron oxide red …
Matched Name: … Ferric oxide …
Matched Description: … and iron(II,III) oxide (Fe3O4) which naturally as magnetite. ... Iron(III) oxide or ferric oxide is the inorganic compound with the formula Fe2O3. ... It is one of the three main oxides of iron, the other two being iron(II) oxide (FeO) the rarer form, …
Matched Mixtures name: … OXIDO DE ZINC - CALAMINA UNGUENTO ... L-Topical CALAMINE 8% ZINC OXIDE 8% ... Aveeno Calamine and Pramoxine Hydrochloride Anti Itch …
Matched Categories: … iron oxide, nanoparticles …
Matched Name: … Ferric oxide …
Matched Description: … and iron(II,III) oxide (Fe3O4) which naturally as magnetite. ... Iron(III) oxide or ferric oxide is the inorganic compound with the formula Fe2O3. ... It is one of the three main oxides of iron, the other two being iron(II) oxide (FeO) the rarer form, …
Matched Mixtures name: … OXIDO DE ZINC - CALAMINA UNGUENTO ... L-Topical CALAMINE 8% ZINC OXIDE 8% ... Aveeno Calamine and Pramoxine Hydrochloride Anti Itch …
Matched Categories: … iron oxide, nanoparticles …
Zinc orotate
Experimental
Matched Synonyms: … Orotate zinc ... Zinc orotate ... Zinc diorotate …
Matched Name: … Zinc orotate …
Matched Iupac: … zinc(2+) bis(2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate) …
Matched Salts name: … Zinc orotate dihydrate …
Matched Name: … Zinc orotate …
Matched Iupac: … zinc(2+) bis(2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate) …
Matched Salts name: … Zinc orotate dihydrate …
Zinc cation
Experimental
Matched Synonyms: … Zinc ion ... Zinc(2+) ... Zinc(II) …
Matched Name: … Zinc cation …
Matched Iupac: … zinc(2+) ion …
Matched Mixtures name: … Orajel 4X Medicated For Toothache and Gum, Cream ... Orajel 4X Medicated PM For Toothache and Gum ... Orajel 4X Medicated For Toothache and Gum …
Matched Categories: … Zinc Compounds …
Matched Name: … Zinc cation …
Matched Iupac: … zinc(2+) ion …
Matched Mixtures name: … Orajel 4X Medicated For Toothache and Gum, Cream ... Orajel 4X Medicated PM For Toothache and Gum ... Orajel 4X Medicated For Toothache and Gum …
Matched Categories: … Zinc Compounds …
Verpasep caltespen
Verpasep caltespen is a recombinant chimeric protein composed of the heat shock protein 65 (Hsp65) from Mycobacterium bovis, and the human papilloma viral (HPV) protein E7. Hsp65, similar to other members of its family of proteins, elicits a strong immune response and may be used to design vaccines against a...
Investigational
Matched Synonyms: … Recombinant fusion protein of Mycobacterium bovis BCG Hsp65 and HPV16 E7 …
Matched Description: … E7 protein is involved in carcinogenesis of anal and cervical tumors, and represents a tumor antigen ... recombinant chimeric protein composed of the heat shock protein 65 (Hsp65) from _Mycobacterium bovis_, and ... Hsp65, similar to other members of its family of proteins, elicits a strong immune response and may be …
Matched Description: … E7 protein is involved in carcinogenesis of anal and cervical tumors, and represents a tumor antigen ... recombinant chimeric protein composed of the heat shock protein 65 (Hsp65) from _Mycobacterium bovis_, and ... Hsp65, similar to other members of its family of proteins, elicits a strong immune response and may be …
Aluminum zirconium tetrachlorohydrex gly
Aluminum zirconium tetrachlorohydrex gly is a common active ingredient in personal care products as an antiperspirant agent. Its main mechanism of action is through blocking the pores via formation of polymer complex and preventing sweat from leaving the body.
Approved
Matched Description: … Its main mechanism of action is through blocking the pores via formation of polymer complex and preventing …
Matched Products: … Ap 22% (regular,sport,musk and Unscented) ... Mitchum Clear Gel A.P. and Deod.supersport ... Body Satin Antiperspirant and Deodorant …
Matched Products: … Ap 22% (regular,sport,musk and Unscented) ... Mitchum Clear Gel A.P. and Deod.supersport ... Body Satin Antiperspirant and Deodorant …
Follitropin
Follitropin is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78...
Approved
Matched Description: … The alpha- and beta- subunits have 92 and 111 amino acids. ... 7 and Asn 24. ... Numerous physio-chemical tests and bioassays indicate that follitropin beta and follitropin alpha are …
Matched Mixtures name: … Pergoveris 150IU/75IU powder and solvent for solution for injection ... MENOGON 75 IU Powder and Solvent for solution for Injection ... Pergoveris Powder and Solvent for Solution for Injection 150iu/75iu …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Genito Urinary System and Sex Hormones ... Gonadotropins and Antigonadotropins ... Sex Hormones and Modulators of the Genital System ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … GONAL-F® 450 IU/0.75 ML POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... GONAL-F® 75 IU (5.5MCG) POWDER AND SOLVENT FOR SOLUTION FOR INJECTION …
Matched Mixtures name: … Pergoveris 150IU/75IU powder and solvent for solution for injection ... MENOGON 75 IU Powder and Solvent for solution for Injection ... Pergoveris Powder and Solvent for Solution for Injection 150iu/75iu …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Genito Urinary System and Sex Hormones ... Gonadotropins and Antigonadotropins ... Sex Hormones and Modulators of the Genital System ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … GONAL-F® 450 IU/0.75 ML POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... GONAL-F® 75 IU (5.5MCG) POWDER AND SOLVENT FOR SOLUTION FOR INJECTION …
Docusate
Docusate, or dioctyl sulfosuccinate, is a stool softener indicated for the treatment of constipation . Docusate acts by increasing the amount of water the stool absorbs in the gut, making the stool softer and easier to pass . Docusate can be orally or rectally administered. Docusate is on the World...
Approved
Matched Description: … Docusate acts by increasing the amount of water the stool absorbs in the gut, making the stool softer and …
Matched Mixtures name: … Senna and Docusate Sodium ... Sennosides and Docusate Sodium ... Senna and Docusate Sodium …
Matched Categories: … Alimentary Tract and Metabolism ... Softener and Emollient Laxatives …
Matched Products: … Up and up stool softener ... Stool Softener easy and gentle …
Matched Mixtures name: … Senna and Docusate Sodium ... Sennosides and Docusate Sodium ... Senna and Docusate Sodium …
Matched Categories: … Alimentary Tract and Metabolism ... Softener and Emollient Laxatives …
Matched Products: … Up and up stool softener ... Stool Softener easy and gentle …
Magnesium
Magnesium is classified as an alkaline earth metal and has 2 hydration shells. The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite and magnesium carbonate. Common dietary sources of magnesium include nuts (cashews, peanuts, almonds), beans, bananas, apples, carrots, broccoli, and leafy...
Approved
Experimental
Investigational
Matched Description: … [A32810] Further, the mineral helps regulate blood pressure and is necessary for RNA, DNA and protein ... [A19349] The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite ... and magnesium carbonate. …
Matched Mixtures name: … Kordel"s Bio-Liquid Women"s Multi With Fish Oil Vegicap ... Acti-cal/mag 2:1 + Zinc and D Caplet ... Hvp Chelated Cal/mag With Zinc and Vitamins C and D …
Matched Categories: … Minerals …
Matched Products: … NMC Magma Mineral Pack ... Minaral mi tea ... Mineral mi tea …
Matched Mixtures name: … Kordel"s Bio-Liquid Women"s Multi With Fish Oil Vegicap ... Acti-cal/mag 2:1 + Zinc and D Caplet ... Hvp Chelated Cal/mag With Zinc and Vitamins C and D …
Matched Categories: … Minerals …
Matched Products: … NMC Magma Mineral Pack ... Minaral mi tea ... Mineral mi tea …
Zinc glycinate
Glycoprotein marker of gastrointestinal cancer.
Experimental
Matched Synonyms: … Zinc bisglycinate ... Zinc(II) glycinate …
Matched Name: … Zinc glycinate …
Matched Iupac: … zinc(2+) bis(2-aminoacetate) …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Zinc Compounds …
Matched Name: … Zinc glycinate …
Matched Iupac: … zinc(2+) bis(2-aminoacetate) …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Zinc Compounds …
Zinc monoethylfumarate
Experimental
Matched Synonyms: … Ethyl fumarate zinc ... Zinc ethyl fumarate ... Zinc di(ethyl fumarate) …
Matched Name: … Zinc monoethylfumarate …
Matched Iupac: … zinc(2+) bis((2E)-4-ethoxy-4-oxobut-2-enoate) …
Matched Name: … Zinc monoethylfumarate …
Matched Iupac: … zinc(2+) bis((2E)-4-ethoxy-4-oxobut-2-enoate) …
Royal jelly
Royal jelly is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Honey Bee Secretion Used in the Nutrition of Larvae and Adult Queens Secreted From Worker Bee Hypopharyngeal …
Matched Mixtures name: … Shine Oramin Natural Korean Ginseng + Royal Jelly with Multivitamins and Minerals. ... WOMEN`S MULTIVITE WITH EVENING PRIMROSE OIL,ROYAL JELLY & KOREAN GINSENG …
Matched Mixtures name: … Shine Oramin Natural Korean Ginseng + Royal Jelly with Multivitamins and Minerals. ... WOMEN`S MULTIVITE WITH EVENING PRIMROSE OIL,ROYAL JELLY & KOREAN GINSENG …
Zinc carbonate
Experimental
Matched Synonyms: … Zinc carbonate ... Zinc subcarbonate ... Basic zinc carbonate …
Matched Name: … Zinc carbonate …
Matched Categories: … Zinc Compounds …
Matched Name: … Zinc carbonate …
Matched Categories: … Zinc Compounds …
Mometasone furoate
Mometasone furoate is a corticosteroid drug that can be used for the treatment of asthma, rhinitis, and certain skin conditions[FDA Label][F4292,F4295]. It has a glucocorticoid receptor binding affinity 22 times stronger than dexamethasone and higher than many other corticosteroids as well . Mometasone furoate is formulated as a dry powder...
Approved
Investigational
Vet approved
Matched Description: … Mometasone furoate is a corticosteroid drug that can be used for the treatment of asthma, rhinitis, and ... It has a glucocorticoid receptor binding affinity 22 times stronger than [dexamethasone] and higher than ... Mometasone furoate is formulated as a dry powder inhaler, nasal spray, and ointment for its different …
Matched Categories: … formoterol and mometasone …
Matched Products: … Up and Up Allergy ... Nasonex Allergy and Congestion ... Nasal Allergy and Congestion Relief …
Matched Categories: … formoterol and mometasone …
Matched Products: … Up and Up Allergy ... Nasonex Allergy and Congestion ... Nasal Allergy and Congestion Relief …
Dexpanthenol
Dexpanthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Dexpanthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A, which acts as a cofactor in many enzymatic reactions that...
Approved
Matched Description: … Dexpanthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and ... Due to its good penetration and high local concentrations, dexpanthanol is used in many topical products ... , such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote …
Matched Mixtures name: … PEDIAVIT ZINC ... Somarexin and C 1000 ... B Complex W C and B12 Inj …
Matched Categories: … Alimentary Tract and Metabolism ... Vitamin D and Analogues ... Amino Acids, Peptides, and Proteins ... Preparations for Treatment of Wounds and Ulcers …
Matched Products: … Eros Aqua Sensations and Care Woman …
Matched Mixtures name: … PEDIAVIT ZINC ... Somarexin and C 1000 ... B Complex W C and B12 Inj …
Matched Categories: … Alimentary Tract and Metabolism ... Vitamin D and Analogues ... Amino Acids, Peptides, and Proteins ... Preparations for Treatment of Wounds and Ulcers …
Matched Products: … Eros Aqua Sensations and Care Woman …
Tilmicosin
Tilmicosin is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with Mannheimia haemolytica.
Investigational
Vet approved
Matched Description: … It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory …
Matched Products: … Tilmovet® 200 g/kg Premix for Medicated Feeding Stuff for Pigs and Rabbits …
Matched Products: … Tilmovet® 200 g/kg Premix for Medicated Feeding Stuff for Pigs and Rabbits …
Zinc acetate
Approved
Investigational
Matched Synonyms: … Zinc acetato ... Zinc diacetate ... Zinc(II) acetate …
Matched Name: … Zinc acetate …
Matched Iupac: … zinc(2+) diacetate …
Matched Mixtures name: … Diphenhydramine HCI and Zinc Acetate ... Diphenhydramine HCl and Zinc Acetate ... Diphenhydramine HCl and Zinc Acetate …
Matched Salts name: … Zinc acetate dihydrate …
Matched Categories: … Minerals ... Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use ... zinc acetate …
Matched Products: … Halls Zinc Defense …
Matched Name: … Zinc acetate …
Matched Iupac: … zinc(2+) diacetate …
Matched Mixtures name: … Diphenhydramine HCI and Zinc Acetate ... Diphenhydramine HCl and Zinc Acetate ... Diphenhydramine HCl and Zinc Acetate …
Matched Salts name: … Zinc acetate dihydrate …
Matched Categories: … Minerals ... Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use ... zinc acetate …
Matched Products: … Halls Zinc Defense …
Lansoprazole
Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux disease (GERD) along with other pathologies...
Approved
Investigational
Matched Description: … Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally ... [A177065] It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective ... at promoting healing in ulcerative diseases, and treating gastroesophageal reflux disease (GERD) along …
Matched Mixtures name: … Lansoprazole, Amoxicillin, and Clarithromycin ... Lansoprazole, Amoxicillin and Clarithromycin ... Lansoprazole, Amoxicillin and Clarithromycin …
Matched Categories: … Alimentary Tract and Metabolism ... lansoprazole, amoxicillin and levofloxacin ... lansoprazole, clarithromycin and tinidazole ... lansoprazole, amoxicillin and metronidazole ... lansoprazole, tetracycline and metronidazole …
Matched Products: … Up and Up Lansoprazole ... Berkley and Jensen Lansoprazole ... Foster and Thrive Acid Reducer …
Matched Mixtures name: … Lansoprazole, Amoxicillin, and Clarithromycin ... Lansoprazole, Amoxicillin and Clarithromycin ... Lansoprazole, Amoxicillin and Clarithromycin …
Matched Categories: … Alimentary Tract and Metabolism ... lansoprazole, amoxicillin and levofloxacin ... lansoprazole, clarithromycin and tinidazole ... lansoprazole, amoxicillin and metronidazole ... lansoprazole, tetracycline and metronidazole …
Matched Products: … Up and Up Lansoprazole ... Berkley and Jensen Lansoprazole ... Foster and Thrive Acid Reducer …
Tefidsogene civaparvovec
Tefidsogene civaparvovec, formerly known as SB-913, is an investigational therapy for genome editing. It consists of an adeno-associated virus (AAV) type 2/6 vector and a zinc finger nuclease (ZFN) system that inserts a correct copy of the Iduronate 2-Sulfatase (IDS) gene into the albumin locus in hepatocytes. Developed by Sangamo...
Experimental
Matched Synonyms: … IDURONATE 2-SULFATASE (HIDS) TRANSGENE CASSETTE, ENCODING PARTS OF EXON 1 PLUS EXONS 2-9 FROM HIDS AND …
Matched Description: … It consists of an adeno-associated virus (AAV) type 2/6 vector and a zinc finger nuclease (ZFN) system …
Matched Description: … It consists of an adeno-associated virus (AAV) type 2/6 vector and a zinc finger nuclease (ZFN) system …
Ibuprofen
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and...
Approved
Matched Description: … in the UK in 1969 and USA in 1974. ... Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered ... [A39074] The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development …
Matched Mixtures name: … Up and Up Cold and Sinus ... Hydrocodone Bitartrate and Ibuprofen ... Hydrocodone Bitartrate and Ibuprofen …
Matched Categories: … Ibuprofen and isomer ... codeine and ibuprofen ... oxycodone and ibuprofen ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Matched Products: … Up and Up Ibuprofen ... Pain and Fever ... Up and Up Childrens Ibuprofen …
Matched Mixtures name: … Up and Up Cold and Sinus ... Hydrocodone Bitartrate and Ibuprofen ... Hydrocodone Bitartrate and Ibuprofen …
Matched Categories: … Ibuprofen and isomer ... codeine and ibuprofen ... oxycodone and ibuprofen ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Matched Products: … Up and Up Ibuprofen ... Pain and Fever ... Up and Up Childrens Ibuprofen …
Elapegademase
Elapegademase is a PEGylated recombinant adenosine deaminase. It can be defined molecularly as a genetically modified bovine adenosine deaminase with a modification in cysteine 74 for serine and with about 13 methoxy polyethylene glycol chains bound via carbonyl group in alanine and lysine residues. Elapegademase is generated in E. coli,...
Approved
Matched Synonyms: … PEPTIDE PRODUCED IN ESCHERICHIA COLI, AN AVERAGE OF 13 RESIDUES ARE SUBSTITUTED ON N.ALPHA..1ALANINE AND ... 356)-PEPTIDE, PRODUCED IN ESCHERICHIA COLI, SUBSTITUTED ON N2 OF THE N-TERMINAL ALANYL RESIDUE (A1) AND …
Matched Description: … as a genetically modified bovine adenosine deaminase with a modification in cysteine 74 for serine and ... with about 13 methoxy polyethylene glycol chains bound via carbonyl group in alanine and lysine residues ... [F1937] Elapegademase is generated in _E. coli_, developed by Leadiant Biosciences and FDA approved on …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Description: … as a genetically modified bovine adenosine deaminase with a modification in cysteine 74 for serine and ... with about 13 methoxy polyethylene glycol chains bound via carbonyl group in alanine and lysine residues ... [F1937] Elapegademase is generated in _E. coli_, developed by Leadiant Biosciences and FDA approved on …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Fimaporfin
Investigational
Matched Synonyms: … or 17,18)-dihydro-21h,23h-porphine-5,10-diyl)bisbenzenesulfonic acid, mixture of three isomers a, b and …
Mozafancogene autotemcel
RP-L102 is a lentiviral vector carrying the Fanconi Anemia-A (FANCA) gene currently being developed by Rocket Pharmaceuticals for the treatment of Fanconi anemia type A
Investigational
Matched Synonyms: … Autologous CD34+-enriched Hematopoietic Stem and Progenitor Cells Transduced with Lentiviral Vector Carrying …
Displaying drugs 301 - 325 of 620 in total