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Displaying drugs 476 - 500 of 14518 in total

Apixaban

Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28,...
Approved
Matched Iupac: … 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3- …
Matched Description: … Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa ... , as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic …
Matched Categories: … Blood and Blood Forming Organs …

Ammonium chloride

Ammonium chloride is an inorganic compound with the formula NH4Cl. It is highly soluble in water producing mildly acidic solutions.
Approved
Investigational
Vet approved
Matched Mixtures name: … Cough and Allergy Syrup With Codeine …
Matched Categories: … Blood and Blood Forming Organs ... Genito Urinary System and Sex Hormones ... Blood Substitutes and Perfusion Solutions …

Hexamidine

Approved
Experimental
Matched Categories: … Biguanides and Amidines ... Antiseptics and Disinfectants ... Ophthalmological and Otological Preparations …

Dornase alfa

Dornase alfa is a biosynthetic form of human deoxyribunuclease I (DNase I) enzyme. It is produced in genetically modified Chinese hamster ovary (CHO) cells using recombinant DNA technology. The 260-amino acid sequence of dornase alfa is identical to the endogenous human enzyme. Dornase alfa cleaves extracellular DNA to 5´-phosphodinucleotide and...
Approved
Matched Description: … Enzymatic breakdown of this extracellular DNA appears to reduce sputum viscosity and viscoelasticity. ... Dornase alfa cleaves extracellular DNA to 5´-phosphodinucleotide and 5´-phosphooligonucleotide end products …
Matched Categories: … Enzymes and Coenzymes ... Cough and Cold Preparations ... Amino Acids, Peptides, and Proteins …

Ganirelix

Ganirelix is a synthetic decapeptide and a competitive gonadotropin-releasing hormone (GnRH) antagonist. Derived from endogenous GnRH, ganirelix has amino acid substitutions. Ganirelix is indicated for controlled ovarian hyperstimulation in assisted reproduction techniques. The first case of pregnancy achieved after the use of ganirelix in an assisted reproduction program was reported...
Approved
Matched Description: … Ganirelix is a synthetic decapeptide and a competitive gonadotropin-releasing hormone (GnRH) antagonist …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Insulin degludec

Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the...
Approved
Matched Description: … tissues such as the liver, fat cells, and skeletal muscle. ... inhibits lipolysis and proteolysis among many other functions. ... can result in symptoms such as fatigue, headache, blurred vision, and increased thirst. …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... insulin degludec and liraglutide ... insulin degludec and insulin aspart ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Cyclopenthiazide

Cyclopenthiazide is a thiazide diuretic with antihypertensive properties. In a double blind, randomized crossover study, cyclopenthiazide was effective in reducing diastolic blood pressure in mildly hypertensive non-insulin dependent diabetic patients . It is a positive allosteric modulator at AMPA-A receptors .
Approved
Matched Categories: … cyclopenthiazide and potassium ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... cyclopenthiazide and potassium-sparing agents ... Low-Ceiling Diuretics and Potassium-Sparing Agents …

Velmanase alfa

Velmanase alfa is a recombinant human lysosomal alpha-mannosidase developed for enzyme replacement therapy to treat alpha-mannosidosis. Alpha-mannosidosis is a rare autosomal recessive lysosomal storage disorder. Patients with alpha-mannosidosis have a genetic mutation that causes a deficiency in the lysosomal enzyme alpha-mannosidase, which is an enzyme responsible for breaking down complex...
Approved
Investigational
Matched Description: … deterioration, such as skeletal abnormalities, motor function impairment, intellectual disability, and ... sugars in the body leads to an array of clinical manifestations leading to progressive neuromuscular and …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …

Tinidazole

A nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections.
Approved
Investigational
Matched Description: … nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and …
Matched Categories: … Alimentary Tract and Metabolism ... norfloxacin and tinidazole ... ciprofloxacin and tinidazole ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Medrogestone

Medrogestone (INN), also known as 6,17α-dimethyl-6-dehydroprogesterone, is a progestational agent derived from 17-methylprogesterone. It was conceived as an alternative for an orally effective contraceptive option. It was developed by Ayerst, approved in Canada in 1969 and its current status is cancelled post-marketing. It was never approved by the FDA.
Approved
Withdrawn
Matched Description: … [A31526] It was developed by Ayerst, approved in Canada in 1969 and its current status is cancelled post-marketing …
Matched Categories: … medrogestone and estrogen ... Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System ... Progestogens and Estrogens, Sequential Preparations …

Diclofenamide

A carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
Approved
Investigational
Matched Categories: … Antiglaucoma Preparations and Miotics ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Ancestim

Ancestim is a non-glycosylated recombinant methionyl human stem cell factor. It is a 166 amino acid protein produced by E. coli with an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine . Ancestim was...
Approved
Investigational
Withdrawn
Matched Description: … Ancestim was developed by Amgen and sold to Biovitrium in December 2008. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …

Molsidomine

Molsidomine is an orally active, long-acting vasodilator, which belongs to the class of medications known as syndnones. Interestingly, it is being studied as being a preventive measure in cerebral infarction .
Approved
Investigational

Laronidase

Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Laronidase is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical...
Approved
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …

Pyruvic acid

An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
Approved
Investigational
Nutraceutical
Matched Description: … An intermediate compound in the metabolism of carbohydrates, proteins, and fats. ... In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous …
Matched Salts name: … Calcium pyruvate …

Hydrocortamate

Hydrocortamate is a synthetic glucocorticoid used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects.
Approved
Matched Description: … trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. ... Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and …
Matched Salts name: … Hydrocortamate hydrochloride …

Prednicarbate

Prednicarbate is a relatively new topical corticosteroid drug that displays a similar potency as hydrocortisone. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a...
Approved
Investigational
Matched Description: … IL-1a is also found in fibroblasts, where it is responsible for proliferation, collagenase induction and …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Glycolic acid

Approved
Investigational

Ganaxolone

Ganaxolone is the 3β-methylated synthetic analog of allopregnanolone, a metabolite of progesterone. Ganaxolone belongs to a class of compounds referred to as neurosteroids. Endogenous neurosteroids, which comprise certain metabolites of progesterone and deoxycorticosterone, bind potently and specifically to GABAA receptors to enhance their inhibitory effects, and are thus known to...
Approved
Investigational
Matched Description: … , bind potently and specifically to GABAA receptors to enhance their inhibitory effects, and ... [A3197] Endogenous neurosteroids, which comprise certain metabolites of progesterone and deoxycorticosterone ... are thus known to have anxiolytic, analgesic, anticonvulsant, sedative, hypnotic, and anesthetic properties …

Brivaracetam

Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam . It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 .
Approved
Investigational

Lornoxicam

Lornoxicam (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and antipyretic properties. Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug. Lornoxicam is approved for use in Japan.
Approved
Investigational
Matched Description: … new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Desoxycorticosterone acetate

Approved
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Lodoxamide

Lodoxamide is a mast-cell stabilizer for topical administration into the eye. Mast-cell stabilizers, first one approved being cromolyn sodium, are used in treatment of ocular hypersensitivity reactions such as vernal conjunctivitis. These conditions often require treatment with anti-inflammatory medications such as ophthalmic NSAIDs or topical steroids which may cause systemic...
Approved
Matched Description: … than topical steroids at decreasing inflammation, mast-cell stabilizers offer another treatment option and …
Matched Categories: … Decongestants and Antiallergics ... Amino Acids, Peptides, and Proteins …

Gabapentin enacarbil

Gabapentin enacarbil is marketed under the name Horizant. It is a prodrug of gabapentin, and indicated in adults for the treatment of Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
Approved
Investigational
Matched Description: … ) and postherpetic neuralgia (PHN). ... It is a prodrug of gabapentin, and indicated in adults for the treatment of Restless Legs Syndrome (RLS …
Matched Categories: … Gabapentin and Prodrugs ... Amino Acids, Peptides, and Proteins …

Piracetam

Piracetam is a nootropic drug in the racetams group, with chemical name 2-oxo-1-pyrrolidine acetamide. It shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative of the neurotransmitter γ-aminobutyric acid (GABA). However its mechanism of action differ from that of endogenous GABA. Piracetam has neuroprotective and...
Approved
Investigational
Matched Description: … Piracetam has neuroprotective and anticonvulsant properties and is reported to improve neural plasticity ... It shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative ... Its efficacy is documented in cognitive disorders and dementia, vertigo, cortical myoclonus, dyslexia …
Matched Categories: … Psychostimulants, Agents Used for ADHD and Nootropics …
Displaying drugs 476 - 500 of 14518 in total