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Displaying drugs 2176 - 2200 of 2740 in total
Carindacillin or Carbenicillin isdanyl was an oral penicillin prodrug of carbenicillin marketed by Pfizer as Geocillin. It is no longer marketed in the United States.
Approved
Investigational
Matched Synonyms: … 6β-{2-[(2,3-dihydro-1H-inden-5-yloxy)carbonyl]-2-phenylacetamido}-2,2-dimethylpenam-3α-carboxylic acid
Matched Iupac: … yloxy)-3-oxo-2-phenylpropanamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Matched Salts name: … Carbenicillin indanyl sodium
NNC-55-0396 is a T-type Ca(2+) channel inhibitor.
Investigational
Matched Synonyms: … Cyclopropanecarboxylic acid, (1s,2s)-2-(2-((3-(1h-benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro …
Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII)....
Approved
Matched Synonyms: … 2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid
Matched Iupac: … [(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid
Matched Description: … It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. ... ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS ... Ramipril may be used in the treatment of hypertension, congestive heart failure, nephropathy, and to …
Matched Categories: … simvastatin, acetylsalicylic acid and ramipril ... atorvastatin, acetylsalicylic acid and ramipril ... ACE Inhibitors and Calcium Channel Blockers ... ACE Inhibitors and Diuretics ... ramipril and felodipine …
Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation.
Approved
Matched Synonyms: … (2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid
Matched Iupac: … (2S)-2-(butane-1-sulfonamido)-3-{4-[4-(piperidin-4-yl)butoxy]phenyl}propanoic acid
Matched Description: … It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Cyclic ... Amino Acids, Aromatic …
Trioxsalen (trimethylpsoralen, trioxysalen or trisoralen) is a furanocoumarin and a psoralen derivative obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of...
Approved
Matched Synonyms: … 6-hydroxy-β,2,7-trimethyl-5-benzofuranacrylic acid, δ-lactone …
Matched Description: … Trioxsalen (trimethylpsoralen, trioxysalen or trisoralen) is a furanocoumarin and a psoralen derivative ... light) for phototherapy treatment of vitiligo and hand eczema. ... In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage …
Indoximod has been used in trials studying the treatment of Glioma, Melanoma, Ependymoma, Gliosarcoma, and Lung Cancer, among others.
Investigational
Matched Synonyms: … (2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid
Matched Iupac: … (2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid
Matched Description: … Indoximod has been used in trials studying the treatment of Glioma, Melanoma, Ependymoma, Gliosarcoma, and
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Amino Acids, Cyclic ... Amino Acids, Aromatic …
Gavorestat is under investigation in clinical trial NCT04902781 (Clinical Benefit, Safety, PK and PD Study of AT-007 in Pediatric Subjects With Classic Galactosemia).
Investigational
Matched Synonyms: … Oxo-3-((5-(Trifluoromethyl)Benzo[D]Thiazol-2-Yl)Methyl)-3,4-Dihydrothieno[3,4-D]Pyridazin-1-Yl)Acetic Acid
Matched Iupac: … -oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3H,4H-thieno[3,4-d]pyridazin-1-yl)acetic acid
Matched Description: … Gavorestat is under investigation in clinical trial NCT04902781 (Clinical Benefit, Safety, PK and PD …
Investigational
Matched Synonyms: … Internalized-arginylglycylaspartic acid cyclic peptide …
Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release from the...
Approved
Matched Synonyms: … 1-(3-mercaptopropionic acid)-8-D-arginine-vasopressin …
Matched Description: … 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and ... solution, intravenous solution, oral tablet and oral lyophilisate [A31662]. ... a prolonged half-life and duration of action compared to endogenous ADH [A31661]. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Vasopressin and Analogues ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name Viread, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is prescribed in combination with other drugs for the management of HIV infection as well as for...
Approved
Investigational
Matched Mixtures name: … Emtricitabine and Tenofovir Disoproxil Fumarate ... Emtricitabine and Tenofovir Disoproxil Fumarate ... Emtricitabine and Tenofovir Disoproxil Fumarate …
Matched Categories: … Tenofovir and prodrugs ... lamivudine and tenofovir disoproxil ... tenofovir disoproxil and emtricitabine ... lamivudine, tenofovir disoproxil and efavirenz ... lamivudine, tenofovir disoproxil and dolutegravir …
Matched Products: … FORMI
Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers, and Normal Volunteers. Entinostat has been investigated for the treatment of Non-Small Lung Cancer, Epigenetic Therapy.
Investigational
Matched Synonyms: … N-[[4-[(2-aminoanilino)-oxomethyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester …
Matched Description: … , and Normal Volunteers. ... Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Acids, Carbocyclic ... Carboxylic Acids
PLX51107 is a potent and selective inhibitor of the bromodomain and extraterminal (BET) protein family.[A257246,A257251] PLX51107 is under investigation in clinical trial NCT04022785 (PLX51107 and Azacitidine in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome).
Investigational
Matched Synonyms: … Benzoic acid, 4-(6-(3,5-dimethyl-4-isoxazolyl)-1-((1s)-1-(2-pyridinyl)ethyl)-1h-pyrrolo(3,2-b)pyridin …
Matched Iupac: … 4-[6-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[1-(pyridin-2-yl)ethyl]-1H-pyrrolo[3,2-b]pyridin-3-yl]benzoic acid
Matched Description: … PLX51107 is a potent and selective inhibitor of the bromodomain and extraterminal (BET) protein family ... [A257246,A257251] PLX51107 is under investigation in clinical trial NCT04022785 (PLX51107 and Azacitidine …
Overactive bladder (OAB) is a common condition negatively impacting the lives of millions of patients worldwide. Due to its urinary symptoms that include nocturia, urgency, and frequency, this condition causes social embarrassment and a poor quality of life.[A185996,A185999] Oxybutynin, also marketed as Ditropan XL, is an anticholinergic medication used for...
Approved
Investigational
Matched Synonyms: … 4-(Diethylamino)-2-butynyl alpha-phenylcyclohexaneglycolic acid ester …
Matched Description: … embarrassment and a poor quality of life. ... Due to its urinary symptoms that include nocturia, urgency, and frequency, this condition causes social ... used for the relief of overactive bladder symptoms that has been optimized for high levels of safety and
Matched Categories: … Genito Urinary System and Sex Hormones ... Drugs for Urinary Frequency and Incontinence ... Acids, Carbocyclic ... Carboxylic Acids ... Hydroxy Acids
Investigational
Matched Synonyms: … pyrrolidine-3-carbonyl)-4-(methoxymethyl)pyrrolidin-3-yl)-5-(trifluoromethyl)phenyl)piperidine-4-carboxylic acid ... 4-piperidinecarboxylic acid, 1-(2-((3s,4r)-1-(((3r,4r)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)-3-pyrrolidinyl …
Matched Iupac: … pyrrolidine-3-carbonyl]-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl)phenyl}piperidine-4-carboxylic acid
Investigational
Matched Synonyms: … -6-((5-methyl-1h-pyrazol-3-yl)amino)-2-pyridinyl)methyl)-2-methyl-, (2r,4r)-,4-piperidinecarboxylic acid ... 4-piperidinecarboxylic acid, 1-((3-chloro-2-fluorophenyl)methyl)-4-((3-fluoro-6-((5-methyl-1h-pyrazol …
Matched Iupac: … -({3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridin-2-yl}methyl)-2-methylpiperidine-4-carboxylic acid
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
Approved
Matched Synonyms: … thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid ... {[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino} -2- oxoethylidene]amino}oxy)-2-methylpropanoic acid
Matched Iupac: … azaniumyl-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetamido]-2-methyl-4-oxoazetidine-1-sulfonate
Matched Description: … , bladder, and kidneys. ... It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges …
Efzofitimod (ATYR1923) is a fusion protein comprised of the immuno-modulatory domain of histidyl tRNA synthetase fused to the FC region of a human antibody. It is a selective modulator of neuropilin-2 that downregulates the innate and adaptive immune response in inflammatory disease states.
Investigational
Matched Synonyms: … Human IgG1Fc- iMod domain (amino acids 2-60) of human HARS fusion protein …
Matched Description: … It is a selective modulator of neuropilin-2 that downregulates the innate and adaptive immune response …
Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.
Approved
Matched Synonyms: … (5Z,11α,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid ... (Z)-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)hept-5-enoic acid ... (E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid
Matched Iupac: … (5Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoic acid
Matched Description: … As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce …
Matched Categories: … Genito Urinary System and Sex Hormones ... Fatty Acids ... Fatty Acids, Unsaturated …
Experimental
Matched Name: … trifluoro-[hydroxy-[hydroxy-[2-(N-methyl-2-nitro-anilino)ethoxy]phosphoryl]oxy-phosphoryl]oxy-beryllium …
Matched Iupac: … acid ... ({hydroxy[(trifluoroberylliuide)oxy]phosphoryl}oxy)({2-[methyl(2-nitrophenyl)amino]ethoxy})phosphinic
Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929 , investigations regarding its possible use as a laxative for...
Approved
Matched Description: … [L6202] Nevertheless, although lactulose received formal FDA approval in 1977 and has since become ... possible use as a laxative for the treatment of chronic constipation did not occur until the 1960s and ... List of Essential Medicines as one of the most effective and safe medicines employed in a health system …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Products: … Duphalac Fruit 667 mg/ml - Lösung zum Einnehmen …
A orally active prolyl-hydroxylase inhibitor which can stabilize hypoxia-inducible transcription factor independent of oxygen availability.
Investigational
Matched Synonyms: … (((1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl)amino)acetic acid
Matched Iupac: … 2-[(1-chloro-4-hydroxyisoquinolin-3-yl)formamido]acetic acid
Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.
Approved
Investigational
Matched Synonyms: … dihydro-8-methoxy-7-((4as,7as)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid
Matched Iupac: … 1H-pyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Matched Description: … Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride …
Matched Products: … Moxifloxacin Acino 400 mg Infusionslösung …
Cyclic adenosine monophosphate (cAMP, cyclic AMP or 3'-5'-cyclic adenosine monophosphate) is a molecule that is important in many biological processes; it is derived from adenosine triphosphate (ATP).
Experimental
Matched Synonyms: … Cyclic adenylic acid
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Tagetitoxin is a bacterial phytotoxin. It preferentially inhibits eukaryotic RNA polymerase.
Experimental
Matched Synonyms: … Acetoxy-7-amino-4-carbamoyl-4-hydroxy-8-(phosphonooxy)-9-oxa-3-thiabicyclo[3.3.1]nonane-1-carboxylic acid
Matched Iupac: … acetyloxy)-7-amino-4-carbamoyl-4-hydroxy-8-(phosphonooxy)-9-oxa-3-thiabicyclo[3.3.1]nonane-1-carboxylic acid
Matched Categories: … Acids, Acyclic ... Carboxylic Acids
Calcium glycerophosphate is a DB01373 salt of glycerophosphoric acid that forms a white, fine, slightly hygroscopic powder. The commercial product is a mixture of calcium beta-, and D-, and L -alpha-glycerophosphate. By FDA, calcium glycerophosphate is considered a generally recognized as safe (GRAS) food ingredient as a nutrient supplement (source...
Approved
Matched Synonyms: … β-glycerophosphoric acid calcium salt …
Matched Description: … Calcium glycerophosphate is a [DB01373] salt of glycerophosphoric acid that forms a white, fine, slightly ... The commercial product is a mixture of calcium beta-, and D-, and L -alpha-glycerophosphate. ... ), or in food products such as gelatins, puddings, and fillings. …
Matched Mixtures name: … Somarexin and C 1000 ... NUTROPLEX LIQUID WITH IRON AND LYSINE …
Displaying drugs 2176 - 2200 of 2740 in total