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Displaying drugs 251 - 275 of 9163 in total

Metrizoic acid

Metrizoic acid is a molecule used as a contrast medium. It present a higher risk of allergic reactions due to its high osmolality. Its approval has been discontinued by the FDA. One study in 1976 demonstrated that metrizoic acid, when used for cardiac angiography, was well tolerated. A total of...
Approved
Matched Description: … A total of 10, 000 injections were administered to 2,028 patients undergoing angiocardiographic procedures ... Seven cases of ventricular fibrillation, and 5 of significant bradycardia/asystole, were associated with ... It present a higher risk of allergic reactions due to its high osmolality. …
Matched Categories: … Diagnostic Uses of Chemicals …

Quinupramine

Quinupramine has been approved in France under the brand name Kinupril, as an antidepressant .
Approved
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Perindopril

Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to...
Approved
Matched Description: … Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of ... is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of ... ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS …
Matched Mixtures name: … COSYREL 10/10 ... ./10 มก./10 มก. ... COVERAM 10 MG/10 MG …
Matched Products: … COVERSYL ARGININE 10 MG ... อะเซอทิล อาร์จินีน 10 มก. ... COVERSYL 10 MG FILM TABLET, 30 ADET …

Diflunisal

Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear to be associated with inhibition of prostaglandin synthesis via the...
Approved
Investigational
Matched Description: … Though its mechanism of action has not been clearly established, most of its actions appear to be associated ... with inhibition of prostaglandin synthesis via the arachidonic acid pathway. ... Diflunisal is used to relieve pain accompanied with inflammation and in the symptomatic treatment of …
Matched Products: … DOLPHIN 250 MG FILM TABLET, 10 TABLET ... DOLPHIN 500 MG FILM TABLET, 10 TABLET …

Etilefrine

Etilefrine is an adrenergic agonist that appears to interact with beta-1 and some alpha-adrenergic receptors. It has been used as a vasoconstrictor agent.
Approved
Withdrawn
Matched Products: … ETILEFRINACLORHIDRATO 10 MG /ML ... ETILEFRINA CLORHIDRATO 10 MG/ ML …

Manidipine

Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages.
Approved
Investigational
Matched Products: … มาดิพลอต 10 มก. ... นิคพี-มานิดิปีน เม็ด 10 มก …

Desipramine

Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, desipramine exerts a positive...
Approved
Investigational
Matched Description: … TCAs are potent inhibitors of serotonin and norepinephrine reuptake. ... See toxicity section below for a complete listing of side effects. ... Secondary amine TCAs, such as desipramine and nortriptyline, are more potent inhibitors of norepinephrine …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Products: … Desipramine-10 - Tab 10mg …

Desonide

A nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses.
Approved
Investigational
Matched Synonyms: … 11β,21-dihydroxy-16α,17-isopropylidenedioxypregna-1,4-diene-3,20-dione ... 11β,21-dihydroxy-16α,17α-isopropylidenedioxypregna-1,4-diene-3,20-dione ... 11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione …
Matched Products: … PRENACID 10 ML GOZ DAMLASI …

Fentanyl

Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like morphine and oxycodone. Fentanyl's high potency has also...
Approved
Illicit
Investigational
Vet approved
Matched Description: … [L6748] Opioid overdoses kill an average of 11 Canadians daily. ... [A179542] Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or ... [A179542] In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Products: … FENTANILO 500 MCG/10 ML ... ENJEKSİYONLUK ÇÖZELTİ, 10 ADET ... ABSTRAL 100MCG DILALTI TABLET, 10 TABLET …

Apadamtase alfa

Thrombotic thrombocytopenic purpura (TTP) is a rare blood clotting disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and various degrees of organ damage. It may be inherited (congenital TTP; cTTP) or acquired due to autoantibodies (immune-mediated TTP; iTTP), although cTTP accounts for <5% of all cases of TTP. Patients with cTTP...
Approved
Investigational
Matched Description: … all cases of TTP. ... disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and various degrees of ... cTTP) or acquired due to autoantibodies (immune-mediated TTP; iTTP), although cTTP accounts for <5% of …

Methylphenidate

Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve the following group of developmentally...
Approved
Investigational
Matched Description: … Concerta also provides a sustained 10-12 hour effect, allowing for once-daily dosing. ... The MLRTM release system allows for a sustained effect for 10-12 hours, allowing for once-daily dosing ... [L6037] CADDRA recommends the use of methylphenidate due to long term studies, of over twenty years in …
Matched Products: … PROHIPER 10 ... RUBIFEN 10 MG ... RITALIN ADULT 10 MG …

Barium sulfate

Barium sulfate is an inorganic compound with the chemical formula BaSO4 . Barium sulfate occurs in nature as the mineral barite. It is also used in various manufacturing applications and mixed into heavy concrete to serve as a radiation shield . This drug is used as a contrast agent in...
Approved
Matched Description: … and high level of clearance from the body [FDA label]. ... Therapeutic advantages of barium sulfate in diagnostic procedures include both its low water solubility ... Barium sulfate is ingested by mouth or administered rectally and combined with granules of effervescent …
Matched Categories: … Diagnostic Uses of Chemicals …

Chlordiazepoxide

An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
Approved
Illicit
Investigational
Matched Description: … It has also been used in the symptomatic treatment of alcohol withdrawal. …
Matched Products: … BENPINE CAPSULE 10 mg ... Medilium Cap 10 10mg …

Varenicline

Varenicline is a prescription medication used to treat smoking addiction. This medication is the first approved nicotinic receptor partial agonist. Specifically, varenicline is a partial agonist of the alpha4/beta2 subtype of the nicotinic acetylcholine receptor. In addition it acts on alpha3/beta4 and weakly on alpha3beta2 and alpha6-containing receptors. A full...
Approved
Investigational
Matched Description: … Specifically, varenicline is a partial agonist of the alpha4/beta2 subtype of the nicotinic acetylcholine ... Pfizer is conducting an additional safety study of the drug, results of which are expected in late 2015 ... Food and Drug Administration warned that Varenicline, in the form of Pfizer Inc's quit-smoking drug, …

Phenylephrine

Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939.
Approved
Matched Description: … [A187370] The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s …
Matched Mixtures name: … Cough-en RX Linctus ... DAYCOLD-HOT 500/10/15/100 MG SAŞE ,10 SAŞE ... ซาร่า โคลด์ พีแอล 10 …
Matched Categories: … Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …
Matched Products: … CENDO EFRISEL 10% ... ฟีซ (10% ยาหยอดตา) ... FENILEFRINA CLORHIDRATO 10% …

Drospirenone

Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with Ethinyl estradiol. Most recently, it was approved by both Health Canada and the FDA in combination with Estetrol as an oral contraceptive therapy.[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to...
Approved
Matched Description: … Drospirenone has been the subject of widespread safety concern due to the possibility of an increased ... risk of venous thromboembolism associated with its use. ... thromboembolism resulting from the use of drospirenone remains unclear, as studies regarding this risk …
Matched Mixtures name: … Zarah 21 ... Yasmin 21 ... Zamine 21 …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Ruxolitinib

Ruxolitinib, formerly known as INCB018424 or INC424, is an anticancer drug and a Janus kinase (JAK) inhibitor. It is a potent and selective inhibitor of JAK1 and JAK2, which are tyrosine kinases involved in cytokine signalling and hematopoiesis. Myeloproliferative neoplasms, such as myelofibrosis and polycythemia vera, are often characterized by...
Approved
Matched Description: … , ruxolitinib was the first ATP-competitive inhibitor of JAK1 and JAK2 ever developed. ... It is a potent and selective inhibitor of JAK1 and JAK2,[A229698] which are tyrosine kinases involved ... [L31958] The topical formulation of ruxolitinib is used to treat atopic dermatitis and vitiligo. …
Matched Products: … JAKAVİ 10 MG TABLET, 168 ADET ... JAKAVİ 10 MG TABLET, 56 ADET …

Digoxin Immune Fab (Ovine)

Digoxin Immune Fab is a sheep antibody (26-10) FAB fragment from sheep immunized with the digoxin derivative Digoxindicarboxymethylamine. It is used as an antidote for overdose of digoxin.
Approved
Matched Description: … It is used as an antidote for overdose of digoxin. ... Digoxin Immune Fab is a sheep antibody (26-10) FAB fragment from sheep immunized with the digoxin derivative …

Betamethasone phosphate

Betamethasone phosphate is a prodrug that is rapidly hydrolyzed, providing rapidly accessible betamethasone to agonize glucocorticoid receptors. Betamethasone provides greater anti-inflammatory activity than prednisolone with less sodium and water retention. Betamethasone sodium phosphate was granted FDA approval on 3 March 1965.
Approved
Vet approved
Matched Synonyms: … Betamethasone 21-phosphate ... Betamethasone 21-(dihydrogen phosphate) …

Iobenguane

Synthetic guanethidine derivative that locates phaeochromocytomas and neuroblastomas. The radioisotope used can either be iodine-123 for imaging or iodine-131 for destruction of tissues that metabolize noradrenaline. Iodine 123 is a cyclotron-produced radionuclide that decays to Te 123 by electron capture. Images are produced by a I123 MIBG scintigraphy. FDA approved...
Approved
Investigational
Matched Description: … The radioisotope used can either be iodine-123 for imaging or iodine-131 for destruction of tissues that …
Matched Categories: … Diagnostic Uses of Chemicals …

Nimodipine

Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Compared to other calcium channel blocking...
Approved
Investigational
Matched Description: … By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth …
Matched Products: … NIMODIPINO 10 MG/50 ML ... Nimotop 10 mg - Infusionsflasche ... NIMODIPINO 10 MG / 50 ML …

Technetium Tc-99m mebrofenin

Technetium Tc 99m Mebrofenin is a diagnostic radiopharmaceutical composed of diisopropyl-iminodiacetic acid (DISIDA) attached to a technetium-99m ion. Following intravenous injection, single photon emission computer tomography (SPECT) imaging of the liver or gallbladder is performed using a gamma camera to detect the gamma rays emitted by the technetium-99m as it...
Approved
Matched Description: … Technetium Tc 99m Mebrofenin is a diagnostic radiopharmaceutical composed of diisopropyl-iminodiacetic ... Following intravenous injection, single photon emission computer tomography (SPECT) imaging of the liver ... More specifically, mebrofenin is taken up into hepatocytes through the action of OATP1B1 and OATP1B3 …
Matched Categories: … Diagnostic Uses of Chemicals …

Dibenzepin

Dibenzepin is approved for use in Europe.
Approved
Matched Iupac: … 2-(dimethylamino)ethyl]-2-methyl-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-10 …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Topiramate

Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with phentermine for chronic weight management therapy...
Approved
Matched Description: … In 2004, topiramate was approved for the prevention of migraine in adults. ... from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of …

Meperidine

A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
Approved
Matched Description: … A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including ... postoperative pain and the pain of labor. ... with morphine and are of shorter duration. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Products: … Demerol 10%-liq Im IV Sc ... Demerol 10%-liq Im Sc 100mg/ml ... PETHIDINE ANTIJEN INJ. 100 MG 10 AMPUL …
Displaying drugs 251 - 275 of 9163 in total