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Did you mean bitopertin of rp 493838 of r 168 of ビトペルチン?
Displaying drugs 2826 - 2850 of 9508 in total

Ketotifen

Ketotifen is a benzocycloheptathiophene derivative with potent antihistaminic and mast cell stabilizing properties. It has a similar structure to some other first-generation antihistamines such as cyproheptadine and azatadine. Ketotifen was first developed in Switzerland in 1970 by Sandoz Pharmaceuticals and was initially marketed for the treatment of anaphylaxis. In the...
Approved
Matched Description: … [A231204] In the US, it is now used in an over-the-counter ophthalmic formulation for the treatment of ... [L32283] In addition, oral ketotifen is used in Mexico and across Europe for the treatment of various ... developed in Switzerland in 1970 by Sandoz Pharmaceuticals and was initially marketed for the treatment of …
Matched Products: … KENALER® - R …

Vibegron

Vibegron is a potent, selective beta-3 adrenergic receptor (β3) agonist that relaxes the detrusor smooth muscle of the bladder, thereby increasing bladder capacity. Vibegron was first approved in Japan in September 2018 for the treatment of overactive bladder, a condition associated with distressing symptoms of urge urinary incontinence, urgency, and...
Approved
Investigational
Matched Iupac: … (6S)-N-(4-{[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl}phenyl)-4-oxo-4H,6H,7H,8H-pyrrolo …
Matched Description: … urinary frequency, and reduced quality of life of patients. ... a potent, selective beta-3 adrenergic receptor (β3) agonist that relaxes the detrusor smooth muscle of ... [L28305] Vibegron was first approved in Japan in September 2018 for the treatment of overactive bladder …

Indapamide

The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a number of lifestyle changes (ie. reduced...
Approved
Matched Description: … an estimated 25% of adults globally. ... [A204155] Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts ... [A204155] Treatment for hypertension should include a number of lifestyle changes (ie. reduced sodium …
Matched Categories: … combinations of sulfonamides …

Maprotiline

Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used...
Approved
Investigational
Matched Description: … Maprotiline is effective at reducing symptoms of anxiety associated with depression. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Hydrocodone

Hydrocodone is a synthetic opioid derivative of codeine. It is commonly used in combination with acetaminophen to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by dextromethorphan in current cough and cold formulations. Hydrocodone's more potent metabolite, hydromorphone...
Approved
Illicit
Investigational
Matched Description: … The FDA first approved Hydrocodone for use as part of the cough suppressant syrup Hycodan in March of ... Hydrocodone is a synthetic opioid derivative of codeine. ... metabolite, [hydromorphone] has also found wide use as an analgesic and is frequently used in cases of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Metamfetamine

Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potential for addiction and abuse. The...
Approved
Illicit
Withdrawn
Matched Description: … group of sympathomimetic amines. ... Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine ... The FDA withdrew its approval for the use of all parenteral drug products containing methamphetamine …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Everolimus

Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and...
Approved
Matched Description: … target of rapamycin) inhibitor. ... It is currently used as an immunosuppressant to prevent rejection of organ transplants. ... Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian …
Matched Categories: … Mammalian target of rapamycin (mTOR) kinase inhibitors …

Prasterone

Prasterone, also known as dehydroepiandrosterone (DHEA) is a major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. In...
Approved
Investigational
Nutraceutical
Matched Description: … Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. ... States, DHEA or DHEAS have been advertised with claims that they may be beneficial for a wide variety of ... treat women experiencing moderate to severe pain during sexual intercourse (dyspareunia), a symptom of …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Lorcaserin

Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. Lorcaserin is...
Approved
Withdrawn
Matched Description: … This decision was based on the results of a clinical trial assessing the risk of heart-related problems ... that found that patients treated with lorcaserin may have a higher risk of cancer. ... Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Paritaprevir

Paritaprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Description: … Lack of significant side effects and short duration of therapy is a considerable advantage over older ... reduced liver-related damage, improved quality of life, reduced incidence of Hepatocellular Carcinoma ... Paritaprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic …
Matched Categories: … Antivirals for treatment of HCV infections …

Radium Ra 223 dichloride

Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was...
Approved
Investigational
Matched Description: … a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of ... Dichloride should not be used in women who are pregnant or may become pregnant due to the high risk of …

Dimenhydrinate

Dimehydrinate was first described in the literature in 1949, and patented in 1950. Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery. Dimenhydrinate, also known as B-dimethylaminoethyl benzohydrol ether 8-chlorotheophyllinate, is indicated to prevent nausea, vomiting, and...
Approved
Matched Description: … Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of ... [L32980,L32985,L32995] Dimenhydrinate is a combination of [Diphenhydramine] and [8-chlorotheophylline ... antagonism of H1 histamine receptors in the vestibular system[A1540] while the excitatory effects are …
Matched Products: … FARMARS(R) DIMENHYDRINATE …

Ambroxol

Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. The substance is a mucoactive drug with several properties including secretolytic and secretomotoric actions that restore the physiological clearance mechanisms of the...
Approved
Investigational
Matched Description: … It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. ... It stimulates synthesis and release of surfactant by type II pneumocytes. ... Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid …
Matched Products: … MUXOL (R) FLEM JARABE NIÑOS ... MUXOL (R) FLEM JARABE ADULTOS …

Rifapentine

Rifapentine is an antibiotic drug used in the treatment of tuberculosis. It inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.
Approved
Investigational
Matched Description: … Rifapentine is an antibiotic drug used in the treatment of tuberculosis. …
Matched Categories: … Drugs for Treatment of Tuberculosis …

Aripiprazole

Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects through agonism of dopaminergic and 5-HT1A receptors and...
Approved
Investigational
Matched Description: … of alpha-adrenergic and 5-HT2A receptors. ... Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar ... [L45859] Aripiprazole exerts its effects through agonism of dopaminergic and 5-HT1A receptors and antagonism …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Products: … ARIPIPRAZOLE ABILIFY(R) TABLETS 5 MG …

Rice bran

Rice bran is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental

Tenofovir disoproxil

Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name Viread, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is prescribed in combination with other drugs for the management of HIV infection as well as for...
Approved
Investigational
Matched Description: … Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name ... _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase ... This drug is prescribed in combination with other drugs for the management of HIV infection as well as …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Megestrol acetate

17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Approved
Investigational
Vet approved
Matched Description: … It has also been used in the palliative treatment of breast cancer. …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Probenecid

The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Approved
Investigational
Matched Description: … It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. ... been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of …
Matched Categories: … combinations of sulfonamides …

Zuclopenthixol

Zuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent. Zuclopenthixol is a thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. Major brands of zuclopenthixol are Cisordinol, Acuphase, and Clopixol. This drug is a liquid. This compound...
Approved
Investigational
Matched Description: … Major brands of zuclopenthixol are Cisordinol, Acuphase, and Clopixol. This drug is a liquid. ... Known drug targets of zuclopenthixol include 5-hydroxytryptamine receptor 2A, D(1B) dopamine receptor …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Reteplase

Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids present in endogenous human tPA. Retavase...
Approved
Investigational
Matched Description: … Retavase contains 355 of the 527 amino acids of native human tPA (amino acids 1-3 and 176-527), and retains ... the activity-related kringle-2 and serine protease domains of human tPA. ... "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of …

Riociguat

Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurrent PH (pulmonary hypertension)...
Approved
Matched Description: … Treatment with riociguat costs USD $7,500 for 30 days of treatment. ... patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of …

Chloramphenicol

An antibiotic first isolated from cultures of Streptomyces venezuelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)...
Approved
Vet approved
Withdrawn
Matched Description: … fatal aplastic anemia associated with this specific route of administration. ... An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically ... p106) The FDA has withdrawn all oral drug products containing chloramphenicol, due to the high risk of …
Matched Categories: … Antiinfectives for Treatment of Acne …

Ondansetron

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties. Having been developed in the 1980s by GlaxoSmithKline and approved by the US FDA since January 1991, ondansetron has...
Approved
Withdrawn
Matched Description: … than 16 mg of ondansetron hydrochloride in a single dose, due to a high risk of QT prolongation. ... It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including ... orally soluble films that are both discreet in administration and less of a burden in comparison to …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Zonisamide

Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of...
Approved
Investigational
Matched Description: … uptake of the excitatory neurotransmitter glutamate. ... to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. ... This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the …
Matched Categories: … combinations of sulfonamides …
Displaying drugs 2826 - 2850 of 9508 in total