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Displaying drugs 276 - 300 of 15174 in total

Practolol

A beta-adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias.
Approved

Azilsartan medoxomil

Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in February 2011. Many guidelines...
Approved
Investigational
Matched Iupac: … (5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1 ... '-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylate …
Matched Description: … , primarily strokes and myocardial infarctions. ... guidelines recommend the use of ARBs as first-line therapy when initiating antihypertensive therapy and ... Lowering blood pressure is associated with a reduced risk of fatal and nonfatal cardiovascular events …
Matched Categories: … azilsartan medoxomil and diuretics ... Angiotensin II receptor blockers (ARBs) and diuretics …

Chlorcyclizine

Chlorcyclizine is a first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can be used as an antiemetic.
Approved
Matched Iupac: … 1-[(4-chlorophenyl)(phenyl)methyl]-4-methylpiperazine …
Matched Description: … Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and ... first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and …

Ethoheptazine

Ethoheptazine is marketed under the name Zactane. It is a phenazepine based opioid analgesic. It was invented in the 1950s and is related to other drugs such as proheptazine. Ethoheptazine is no longer marketed in the United States.
Approved
Withdrawn
Matched Iupac: … ethyl 1-methyl-4-phenylazepane-4-carboxylate …
Matched Description: … It was invented in the 1950s and is related to other drugs such as proheptazine. …

Tofacitinib

Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant to methotrexate....
Approved
Investigational
Matched Iupac: … 3-[(3R,4R)-4-methyl-3-[methyl({7H-pyrrolo[2,3-d]pyrimidin-4-yl})amino]piperidin-1-yl]-3-oxopropanenitrile …
Matched Description: … Known adverse effects include nausea and headache as well as more serious immunologic and hematological ... kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and ... tofacitinib has also been studied in clinical trials for the prevention of organ transplant rejection, and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Pexidartinib

Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first systemic therapy for adult patients with symptomatic tenosynovial giant cell tumor. Tenosynovial...
Approved
Investigational
Matched Iupac: … 5-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}methyl)-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin …
Matched Description: … tendon sheaths to thicken and overgrow, leading to damage in surrounding joint tissue. ... Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August ... [A182243] Pexidartinib is available in oral formulations and it is commonly marketed as Turalio. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Pargyline

Pargyline is a monoamine oxidase inhibitor with antihypertensive properties.
Approved
Matched Iupac: … benzyl(methyl)(prop-2-yn-1-yl)amine …
Matched Categories: … pargyline and diuretics ... MAO Inhibitors and Diuretics …

Pirfenidone

Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is proposed to primarily regulate...
Approved
Investigational
Matched Iupac: … 5-methyl-1-phenyl-1,2-dihydropyridin-2-one …
Matched Description: … [A251370] It is an antifibrotic agent with anti-inflammatory and antioxidant properties [A251370] that ... fully understood, pirfenidone is proposed to primarily regulate tumor necrosis factor (TNF) pathways and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Cocarboxylase

The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.
Approved
Experimental
Matched Iupac: … )-4-methyl-1,3-thiazol-3-ium ... 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(hydrogen phosphonatooxy)(hydroxy)phosphoryl]oxy}ethyl …
Matched Description: … It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase …
Matched Categories: … Enzymes and Coenzymes …

Avanafil

Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both sildenafil and vardenafil but less selectivity than tadalafil, suggesting a relatively lower risk of visual disturbances associated with...
Approved
Matched Iupac: … -yl)methyl]pyrimidine-5-carboxamide ... 4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-[(pyrimidin-2 …
Matched Description: … other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and …
Matched Categories: … Genito Urinary System and Sex Hormones …

Suvorexant

Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia.
Approved
Investigational
Matched Iupac: … 5-chloro-2-[(5R)-5-methyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl]-1,3-benzoxazole …
Matched Description: … wakefulness and arousal. ... Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing …
Matched Categories: … Hypnotics and Sedatives ... Miscellaneous Anxiolytics Sedatives and Hypnotics …

Norelgestromin

Norelgestromin is a drug used in contraception. Norelgestromin is the active progestin responsible for the progestational activity that occurs in women after application of ORTHO EVRA patch.
Approved
Investigational
Matched Mixtures name: … Norelgestromin and Ethinly Estradiol ... Norelgestromin and Ethinyl Estradiol ... Norelgestromin and Ethinyl Estradiol …
Matched Categories: … norelgestromin and ethinylestradiol ... Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System ... Combination Contraceptives (with Estrogen and derivatives) …

Triprolidine

First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness.
Approved
Matched Description: … It is a component of cough and cold medicines. It may cause drowsiness. ... First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. …
Matched Mixtures name: … and Flu Clear and Cool ... Mucus DM Fast Max Day Cold and Flu and Night Cold and Flu ... Mucinex Fast-Max Cold and Flu and Mucinex NightShift Cold and Flu …

Dehydrocholic acid

Dehydrocholic acid is a synthetic bile acid that was prepared from the oxidation of cholic acid with chromic acid . It has been used for stimulation of biliary lipid secretion. The use of dehydrocholic acid in over-the-counter products has been discontinued by Health Canada.
Approved
Investigational
Matched Categories: … Bile Acids and Salts ... Cholagogues and Choleretics …

Selenomethionine Se-75

Approved
Matched Iupac: … (2S)-2-amino-4-[methyl(⁷⁵Se)selanyl]butanoic acid …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Iobenguane sulfate I-123

Iobenguane sulfate I-123 is a radiopharmaceutical used in gamma-scintigraphy of adrenergically inervated tissues [FDA Label].
Approved
Investigational
Matched Iupac: … bis(N-{[3-(¹²³I)iodophenyl]methyl}guanidine); sulfuric acid …

Kinetin

Kinetin is a cytokinin which are plant hormones promotes cell division and plant growth. It was shown to naturally exist in DNA of organisms including humans and various plants. While kinetin is used in tissue cultures to produce new plants, it is also found in cosmetic products as an anti-aging...
Approved
Matched Iupac: … N-[(furan-2-yl)methyl]-7H-purin-6-amine …
Matched Description: … Kinetin is a cytokinin which are plant hormones promotes cell division and plant growth. ... It was shown to naturally exist in DNA of organisms including humans and various plants. …

Benserazide

When levodopa is used by itself as a therapy for treating Parkinson's disease, its ubiquitous metabolism into dopamine is responsible for a resultant increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. This can result in a number of side effects like nausea, vomiting,...
Approved
Investigational
Matched Iupac: … 2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide …
Matched Description: … dopamine is responsible for a resultant increase in the levels of circulating dopamine in the blood and ... approved another similar levodopa/dopa decarboxylase inhibitor combination in the form of levodopa and ... particular, although the specific levodopa/benserazide combination is formally approved for use in Canada and …

Norethisterone

Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with levonorgestrel and its derivatives, and is the active form of several other progestins including norethynodrel and lynestrenol. Norethisterone mimics the actions of endogenous...
Approved
Matched Iupac: … (1R,3aS,3bR,9aR,9bS,11aS)-1-ethynyl-1-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H, …
Matched Description: … derivatives, and is the active form of several other progestins including [norethynodrel] and [lynestrenol ... endometriosis, and was not marketed for use as an oral contraceptive until 1962. ... [A10367] It is further classified as a second-generation progestin, along with [levonorgestrel] and its …
Matched Mixtures name: … Norethindrone and Ethinyl Estradiol and Ferrous Fumarate ... Norethindrone and Ethinyl Estradiol and Ferrous Fumarate ... Norethindrone and Ethinyl Estradiol, and Ferrous Fumarate …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... norethisterone and estrogen ... norethisterone and estrogen ... norethisterone and ethinylestradiol …

Norethynodrel

A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and endometriosis. As a contraceptive, it has usually been administered in combination with MESTRANOL.
Approved
Matched Iupac: … (1R,3aS,3bR,9bS,11aS)-1-ethynyl-1-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,6H,7H,8H,9H,9bH,10H,11H,11aH-cyclopenta …
Matched Description: … It has been used in the treatment of functional uterine bleeding and endometriosis. ... A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. …
Matched Categories: … noretynodrel and estrogen ... Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System ... Combination Contraceptives (with Estrogen and derivatives) …

Erythromycin

Erythromycin is a bacteriostatic antibiotic drug produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and belongs to the macrolide group of antibiotics which consists of Azithromycin, Clarithromycin, Spiramycin and others. It was originally discovered in 1952. Erythromycin is widely used for treating a variety of infections, including those...
Approved
Investigational
Vet approved
Matched Description: … antibiotic drug produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and ... the macrolide group of antibiotics which consists of [Azithromycin], [Clarithromycin], [Spiramycin] and ... [L5245,L7261] It is available for administration in various forms, including intravenous, topical, and …
Matched Mixtures name: … Erythromycin and Benzoyl Peroxide ... Erythromycin and Benzoyl Peroxide ... Erythromycin and Benzoyl Peroxide …
Matched Categories: … Erythromycin and similars ... Macrolides, Lincosamides and Streptogramins …

Amodiaquine

A 4-aminoquinoquinoline compound with anti-inflammatory properties.
Approved
Investigational
Matched Iupac: … 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol …
Matched Categories: … artesunate and amodiaquine ... Antiparasitic Products, Insecticides and Repellents …

Erdosteine

Erdosteine is a drug that causes a breakdown of mucus, also known as a mucolytic agent. It is a thiol derivative produced for the clinical management of chronic obstructive bronchitis, in addition to infective exacerbations of chronic bronchitis. This drug contains sulfhydryl groups which are released after erdosteine undergoes hepatic...
Approved
Investigational
Matched Iupac: … 2-({[(2-oxothiolan-3-yl)carbamoyl]methyl}sulfanyl)acetic acid …
Matched Description: … and more effectively than placebo and reduced the adhesivity of sputum more effectively than ambroxol ... Erdosteine 300mg twice daily reduced cough (both frequency and severity) and sputum viscosity more quickly ... Erdosteine has been shown to be safe and well tolerated in clinical trials. …
Matched Categories: … Cough and Cold Preparations …

Etafedrine

Etafedrine (INN) or ethylephedrine is a long-acting bronchodilator and has been an ingredient combined with other drugs in the brand names Nethaprin and Dalmacol . It was previously available as both the free base and as the hydrochloride salt manufactured by Sanofi-Aventis (now Sanofi) has been discontinued . Ethylephedrine is...
Approved
Matched Iupac: … (1R,2S)-2-[ethyl(methyl)amino]-1-phenylpropan-1-ol …
Matched Description: … with other drugs in the brand names Nethaprin [A32757] and Dalmacol [L2568]. ... Etafedrine (INN) or ethylephedrine is a long-acting bronchodilator and has been an ingredient combined ... It was previously available as both the free base and as the hydrochloride salt manufactured by Sanofi-Aventis …

Procinonide

Approved
Investigational
Displaying drugs 276 - 300 of 15174 in total