Displaying drugs 3026 - 3050 of 3264 in total
Almonertinib
Almonertinib is a third-generation EGFR tyrosine kinase inhibitor targeting EGFR-sensitizing and T790M resistance mutations.[A231859, A231864, A231869] It is being investigated against advanced or metastatic EGFR-mutated non-small cell lung cancer (NSCLC).
Investigational
Matched Description: … [A231859, A231864, A231869] It is being investigated against advanced or metastatic EGFR-mutated non-small …
Tanshinone I
Investigational
Matched Categories: … Analgesics, Non-Narcotic ... Anti-Inflammatory Agents, Non-Steroidal …
Berbamine
Investigational
Matched Categories: … Analgesics, Non-Narcotic ... Anti-Inflammatory Agents, Non-Steroidal …
Coronavirus-Like Particle COVID-19 Vaccine
The Coronavirus-Like Particle COVID-19 Vaccine is in development and testing through Meidcago in Quebec City, Canada. The vaccine was developed by creating SARS-Cov-2 virus-like particles (CoVLPs), which mimic the structure of the virus without carrying the genetic components required for infection. VLPs are thought to have multiple mechanisms involving the...
Investigational
Matched Description: … of the virus without carrying the genetic components required for infection. ... The vaccine was developed by creating SARS-Cov-2 virus-like particles (CoVLPs), which mimic the structure …
Viral Macrophage-Inflammatory Protein
Viral macrophage inflammatory protein-II (vMIP) is a highly basic protein and human chemokine analog encoded by human herpesvirus-8. The structure of vMIP consists of 71 residues and is a monomer under most conditions. It helps its virus evade the host immune system through selectively blocking and activating different receptors, preferentially...
Investigational
Matched Description: … It helps its virus evade the host immune system through selectively blocking and activating different …
L-methionine sulfone
Experimental
Phenoxypropazine
Phenoxypropazine is a non-selective and irreversible monoamine oxidase enzyme inhibitor (MAOI), belonging to the hydrazine chemical class. It was marketed as an antidepressant in 1961 but was later withdrawn in 1966 because of its hepatotoxic potential.
Withdrawn
Matched Description: … Phenoxypropazine is a non-selective and irreversible monoamine oxidase enzyme inhibitor (MAOI), belonging …
Zeranol
Zeranol is a non-steroidal estrogen agonist. It is a mycotoxin, derived from fungi in the Fusarium family, and may be found as a contaminant in fungus-infected crops. It is 3-4x more potent as an estrogen agonist than the related compound zearalenone.
Experimental
Vet approved
Matched Description: … Zeranol is a non-steroidal estrogen agonist. …
Matched Categories: … Estrogens, Non-Steroidal …
Matched Categories: … Estrogens, Non-Steroidal …
Recombinant SARS-CoV-2 Vaccine (Sf9 Cell)
The Recombinant SARS-CoV-2 Vaccine was created by inserting genes of the SARS-CoV-2 spike protein’s receptor-binding domain into a baculovirus expression system[F4738, A226853]. In pre-clinical trial testing on mice, rabbits, and non-human primates, the candidate was able to induce a functional antibody response within 7-14 days of initial injection . It...
Investigational
Matched Description: … It also provided protection in non-human primates to an in vivo challenge with SARS-CoV-2[A226853]. ... In pre-clinical trial testing on mice, rabbits, and non-human primates, the candidate was able to induce …
Epsilon-N-methyllysine
Experimental
Allysine
Experimental
N-Carboxymethionine
Experimental
LY2275796
LY2275796 is a second-generation antisense anti-cancer drug candidate for clinical development. LY2275796 targets eukaryotic initiation factor- 4E (eIF-4E), a protein involved in the translation of key growth and survival factors that drive tumor progression, angiogenesis and metastases.
Investigational
Apramycin
Apramycin is an aminoglycoside antibiotic and has a bactericidal action against many gram-negative bacteria. Apramycin is a structurally unique antibiotic that contains a bicyclic sugar moiety and a monosubstituted deoxystreptamine. It is not approved for use in humans.
Experimental
Vet approved
Phosphoaminophosphonic acid guanylate ester
A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of adenylate cyclase.
Experimental
Matched Description: … A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is …
Gavestinel
Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM). Gavestinel displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites and is orally bioavailable and active in vivo.
Investigational
Matched Description: … Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding …
SC-236
SC-236 is a potent, selective, orally active inhibitor of cyclooxygenase-2 (COX-2) that has been studied in cancer therapy , lower back pain , and inflammation , , , .
Experimental
Investigational
Matched Categories: … Analgesics, Non-Narcotic ... Anti-Inflammatory Agents, Non-Steroidal …
Antimonous acid
Experimental
Dioxo(sulfanyl)molybdenum
Experimental
Ferric hydroxide
Experimental
Mercuric chloride
Mercury chloride (HgCl2) is a highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant. Mercuric chloride was used to disinfect wounds by Arab physicians in the Middle Ages but modern...
Experimental
Pinatuzumab vedotin
Pinatuzumab vedotin is under investigation in clinical trial NCT01691898 (A Study of Pinatuzumab Vedotin (DCDT2980S) Combined With Rituximab or Polatuzumab Vedotin (DCDS4501A) Combined With Rituximab or Obinutuzumab in Participants With Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma (NHL)).
Investigational
Matched Description: … DCDS4501A) Combined With Rituximab or Obinutuzumab in Participants With Relapsed or Refractory B-Cell Non-Hodgkin's …
Alanine
Alanine is a non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and the central nervous system.
Nutraceutical
Matched Description: … Alanine is a non-essential amino acid that occurs in high levels in its free state in plasma. …
Neovastat
Neovastat is a naturally occurring anti-angiogenic compound, extracted from cartilage, with multiple anti-angiogenic mechanisms of action that provide broad therapeutic potential for a number of diseases. It is currently in international Phase III trials for renal cell carcinoma and non-small-cell lung cancer.
Investigational
Matched Description: … It is currently in international Phase III trials for renal cell carcinoma and non-small-cell lung cancer …
Oxametacin
Experimental
Matched Categories: … Antiinflammatory and Antirheumatic Products, Non-Steroids …
Displaying drugs 3026 - 3050 of 3264 in total